Notebook

10X genomics data¶

This tutorials shows how to annotate pathway data from a 10x Genomics Single-Cell dataset. In this tutorial, the data being used is the same in the scanpy Preprocessing and clustering 3k PBMCs tutorial.

In [1]:

!mkdir data
!wget http://cf.10xgenomics.com/samples/cell-exp/1.1.0/pbmc3k/pbmc3k_filtered_gene_bc_matrices.tar.gz -O data/pbmc3k_filtered_gene_bc_matrices.tar.gz
!cd data; tar -xzf pbmc3k_filtered_gene_bc_matrices.tar.gz

mkdir: cannot create directory ‘data’: File exists
--2021-08-03 19:25:10--  http://cf.10xgenomics.com/samples/cell-exp/1.1.0/pbmc3k/pbmc3k_filtered_gene_bc_matrices.tar.gz
Resolving cf.10xgenomics.com (cf.10xgenomics.com)... 2606:4700::6812:ad, 2606:4700::6812:1ad, 104.18.0.173, ...
Connecting to cf.10xgenomics.com (cf.10xgenomics.com)|2606:4700::6812:ad|:80... connected.
HTTP request sent, awaiting response... 301 Moved Permanently
Location: https://cf.10xgenomics.com/samples/cell-exp/1.1.0/pbmc3k/pbmc3k_filtered_gene_bc_matrices.tar.gz [following]
--2021-08-03 19:25:10--  https://cf.10xgenomics.com/samples/cell-exp/1.1.0/pbmc3k/pbmc3k_filtered_gene_bc_matrices.tar.gz
Connecting to cf.10xgenomics.com (cf.10xgenomics.com)|2606:4700::6812:ad|:443... connected.
HTTP request sent, awaiting response... 200 OK
Length: 7621991 (7,3M) [application/x-tar]
Saving to: ‘data/pbmc3k_filtered_gene_bc_matrices.tar.gz’

data/pbmc3k_filtere 100%[===================>]   7,27M  3,45MB/s    in 2,1s    

2021-08-03 19:25:14 (3,45 MB/s) - ‘data/pbmc3k_filtered_gene_bc_matrices.tar.gz’ saved [7621991/7621991]

In [2]:

import numpy as np
import pandas as pd
import scanpy as sc

Following scanpy tutorial¶

In [3]:

adata = sc.read_10x_mtx(
    'data/filtered_gene_bc_matrices/hg19/',  
    var_names='gene_symbols',                
    cache=True)                              

In [4]:

adata.var_names_make_unique()  

In [5]:

sc.pp.filter_cells(adata, min_genes=200)
sc.pp.filter_genes(adata, min_cells=3)
adata.var['mt'] = adata.var_names.str.startswith('MT-')  
sc.pp.calculate_qc_metrics(adata, qc_vars=['mt'], percent_top=None, log1p=False, inplace=True)
adata = adata[adata.obs.n_genes_by_counts < 2500, :]
adata = adata[adata.obs.pct_counts_mt < 5, :]
sc.pp.normalize_total(adata, target_sum=1e4)
sc.pp.log1p(adata)
sc.pp.highly_variable_genes(adata, min_mean=0.0125, max_mean=3, min_disp=0.5)
adata.raw = adata
adata = adata[:, adata.var.highly_variable]
sc.pp.regress_out(adata, ['total_counts', 'pct_counts_mt'])
sc.pp.scale(adata, max_value=10)

/home/joao/miniconda3/envs/descartes-rpa/lib/python3.9/site-packages/scanpy/preprocessing/_normalization.py:138: UserWarning: Revieved a view of an AnnData. Making a copy.
  view_to_actual(adata)

In [6]:

sc.tl.pca(adata, svd_solver='arpack')
sc.pp.neighbors(adata, n_neighbors=10, n_pcs=40)

In [7]:

sc.tl.umap(adata)
sc.tl.leiden(adata)

In [8]:

new_cluster_names = [
    'CD4 T', 'CD14 Monocytes',
    'B', 'CD8 T',
    'NK', 'FCGR3A Monocytes',
    'Dendritic', 'Megakaryocytes']
adata.rename_categories('leiden', new_cluster_names)

Reactome pathway analysis¶

Here is where the pathway annotation occurs. You can map pathway activity to each Single-Cell cluster found.

In [9]:

from descartes_rpa import get_pathways_for_group

In [10]:

get_pathways_for_group(adata, groupby="leiden")

In [11]:

from descartes_rpa.pl import marker_genes

In [12]:

marker_genes(adata, n_genes=3)

WARNING: dendrogram data not found (using key=dendrogram_leiden). Running `sc.tl.dendrogram` with default parameters. For fine tuning it is recommended to run `sc.tl.dendrogram` independently.
WARNING: saving figure to file dotplot_marker_genes.pdf

Now, we can use pathways plotting to check pathways shared between the clusters¶

In [13]:

from descartes_rpa.pl import shared_pathways

In [14]:

shared_pathways(adata, clusters=["B", "NK", "CD4 T", "Megakaryocytes"])

In [15]:

from descartes_rpa import get_shared

In [16]:

get_shared(adata, clusters=["B", "NK", "CD4 T", "Megakaryocytes"])

Out[16]:

	stId	name
0	R-HSA-1280218	Adaptive Immune System
1	R-HSA-168256	Immune System
2	R-HSA-1280215	Cytokine Signaling in Immune system
3	R-HSA-422475	Axon guidance
4	R-HSA-983705	Signaling by the B Cell Receptor (BCR)
5	R-HSA-9675108	Nervous system development
6	R-HSA-71291	Metabolism of amino acids and derivatives
7	R-HSA-8953854	Metabolism of RNA
8	R-HSA-2262752	Cellular responses to stress
9	R-HSA-8953897	Cellular responses to stimuli
10	R-HSA-1266738	Developmental Biology
11	R-HSA-6798695	Neutrophil degranulation
12	R-HSA-392499	Metabolism of proteins
13	R-HSA-168249	Innate Immune System
14	R-HSA-1430728	Metabolism

You can also plot shared pathways between all clusters. However, this doesn't look good on Jupyter Notebook. This plot creates a PNG file with 300 dpi where you can visualize it better.

In [17]:

shared_pathways(adata, file_name="all_clusters.png")

Another functionality is to look which pathways were annotated in each clusters. Below you can see an example on the "Megakaryocytes" cluster

In [18]:

from descartes_rpa.pl import pathways

In [19]:

pathways(adata, "Megakaryocytes")

Out[19]:

	stId	dbId	name	species	llp	entities	reactions	inDisease
0	R-HSA-76002	76002	Platelet activation, signaling and aggregation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 291, 'found': 8...	{'resource': 'TOTAL', 'total': 116, 'found': 2...	False
1	R-HSA-114608	114608	Platelet degranulation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 139, 'found': 6...	{'resource': 'TOTAL', 'total': 11, 'found': 3,...	False
2	R-HSA-76005	76005	Response to elevated platelet cytosolic Ca2+	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 146, 'found': 6...	{'resource': 'TOTAL', 'total': 14, 'found': 3,...	False
3	R-HSA-109582	109582	Hemostasis	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 801, 'found': 1...	{'resource': 'TOTAL', 'total': 334, 'found': 4...	False
4	R-HSA-445355	445355	Smooth Muscle Contraction	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 49, 'found': 4,...	{'resource': 'TOTAL', 'total': 11, 'found': 7,...	False
5	R-HSA-8936459	8936459	RUNX1 regulates genes involved in megakaryocyt...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 78, 'found': 4,...	{'resource': 'TOTAL', 'total': 33, 'found': 22...	False
6	R-HSA-418594	418594	G alpha (i) signalling events	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 425, 'found': 7...	{'resource': 'TOTAL', 'total': 74, 'found': 32...	False
7	R-HSA-140877	140877	Formation of Fibrin Clot (Clotting Cascade)	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 43, 'found': 3,...	{'resource': 'TOTAL', 'total': 61, 'found': 5,...	False
8	R-HSA-380108	380108	Chemokine receptors bind chemokines	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 57, 'found': 3,...	{'resource': 'TOTAL', 'total': 19, 'found': 3,...	False
9	R-HSA-5250924	5250924	B-WICH complex positively regulates rRNA expre...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 62, 'found': 3,...	{'resource': 'TOTAL', 'total': 3, 'found': 2, ...	False
10	R-HSA-5250913	5250913	Positive epigenetic regulation of rRNA expression	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 80, 'found': 3,...	{'resource': 'TOTAL', 'total': 7, 'found': 4, ...	False
11	R-HSA-5625740	5625740	RHO GTPases activate PKNs	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 80, 'found': 3,...	{'resource': 'TOTAL', 'total': 20, 'found': 9,...	False
12	R-HSA-195258	195258	RHO GTPase Effectors	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 326, 'found': 5...	{'resource': 'TOTAL', 'total': 113, 'found': 2...	False
13	R-HSA-977225	977225	Amyloid fiber formation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 89, 'found': 3,...	{'resource': 'TOTAL', 'total': 33, 'found': 3,...	False
14	R-HSA-388396	388396	GPCR downstream signalling	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 785, 'found': 7...	{'resource': 'TOTAL', 'total': 168, 'found': 6...	False
15	R-HSA-397014	397014	Muscle contraction	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 213, 'found': 4...	{'resource': 'TOTAL', 'total': 42, 'found': 15...	False
16	R-HSA-2682334	2682334	EPH-Ephrin signaling	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 101, 'found': 3...	{'resource': 'TOTAL', 'total': 56, 'found': 4,...	False
17	R-HSA-140875	140875	Common Pathway of Fibrin Clot Formation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 25, 'found': 2,...	{'resource': 'TOTAL', 'total': 29, 'found': 1,...	False
18	R-HSA-5627123	5627123	RHO GTPases activate PAKs	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 27, 'found': 2,...	{'resource': 'TOTAL', 'total': 15, 'found': 4,...	False
19	R-HSA-9620244	9620244	Long-term potentiation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 31, 'found': 2,...	{'resource': 'TOTAL', 'total': 7, 'found': 6, ...	False
20	R-HSA-372790	372790	Signaling by GPCR	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 864, 'found': 7...	{'resource': 'TOTAL', 'total': 354, 'found': 6...	False
21	R-HSA-162582	162582	Signal Transduction	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 2993, 'found': ...	{'resource': 'TOTAL', 'total': 2445, 'found': ...	False
22	R-HSA-8939211	8939211	ESR-mediated signaling	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 256, 'found': 4...	{'resource': 'TOTAL', 'total': 111, 'found': 1...	False
23	R-HSA-8878171	8878171	Transcriptional regulation by RUNX1	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 261, 'found': 4...	{'resource': 'TOTAL', 'total': 132, 'found': 2...	False
24	R-HSA-451326	451326	Activation of kainate receptors upon glutamate...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 34, 'found': 2,...	{'resource': 'TOTAL', 'total': 6, 'found': 3, ...	False
25	R-HSA-73728	73728	RNA Polymerase I Promoter Opening	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 34, 'found': 2,...	{'resource': 'TOTAL', 'total': 2, 'found': 1, ...	False
26	R-HSA-1474165	1474165	Reproduction	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 123, 'found': 3...	{'resource': 'TOTAL', 'total': 24, 'found': 3,...	False
27	R-HSA-5334118	5334118	DNA methylation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 36, 'found': 2,...	{'resource': 'TOTAL', 'total': 7, 'found': 7, ...	False
28	R-HSA-5626467	5626467	RHO GTPases activate IQGAPs	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 36, 'found': 2,...	{'resource': 'TOTAL', 'total': 5, 'found': 2, ...	False
29	R-HSA-212165	212165	Epigenetic regulation of gene expression	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 139, 'found': 3...	{'resource': 'TOTAL', 'total': 34, 'found': 21...	False
30	R-HSA-194315	194315	Signaling by Rho GTPases	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 709, 'found': 6...	{'resource': 'TOTAL', 'total': 203, 'found': 3...	False
31	R-HSA-9716542	9716542	Signaling by Rho GTPases, Miro GTPases and RHO...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 725, 'found': 6...	{'resource': 'TOTAL', 'total': 212, 'found': 3...	False
32	R-HSA-212300	212300	PRC2 methylates histones and DNA	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 44, 'found': 2,...	{'resource': 'TOTAL', 'total': 4, 'found': 4, ...	False
33	R-HSA-9670095	9670095	Inhibition of DNA recombination at telomere	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 48, 'found': 2,...	{'resource': 'TOTAL', 'total': 4, 'found': 3, ...	False
34	R-HSA-5625886	5625886	Activated PKN1 stimulates transcription of AR ...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 49, 'found': 2,...	{'resource': 'TOTAL', 'total': 11, 'found': 8,...	False
35	R-HSA-427359	427359	SIRT1 negatively regulates rRNA expression	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 45, 'found': 2,...	{'resource': 'TOTAL', 'total': 5, 'found': 3, ...	False
36	R-HSA-427389	427389	ERCC6 (CSB) and EHMT2 (G9a) positively regulat...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 48, 'found': 2,...	{'resource': 'TOTAL', 'total': 4, 'found': 2, ...	False
37	R-HSA-195721	195721	Signaling by WNT	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 332, 'found': 4...	{'resource': 'TOTAL', 'total': 157, 'found': 1...	False
38	R-HSA-1251985	1251985	Nuclear signaling by ERBB4	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 47, 'found': 2,...	{'resource': 'TOTAL', 'total': 34, 'found': 2,...	False
39	R-HSA-2299718	2299718	Condensation of Prophase Chromosomes	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 55, 'found': 2,...	{'resource': 'TOTAL', 'total': 10, 'found': 8,...	False
40	R-HSA-912446	912446	Meiotic recombination	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 58, 'found': 2,...	{'resource': 'TOTAL', 'total': 9, 'found': 1, ...	False
41	R-HSA-73772	73772	RNA Polymerase I Promoter Escape	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 64, 'found': 2,...	{'resource': 'TOTAL', 'total': 2, 'found': 1, ...	False
42	R-HSA-3299685	3299685	Detoxification of Reactive Oxygen Species	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 65, 'found': 2,...	{'resource': 'TOTAL', 'total': 34, 'found': 3,...	False
43	R-HSA-9006931	9006931	Signaling by Nuclear Receptors	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 384, 'found': 4...	{'resource': 'TOTAL', 'total': 192, 'found': 1...	False
44	R-HSA-201722	201722	Formation of the beta-catenin:TCF transactivat...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 67, 'found': 2,...	{'resource': 'TOTAL', 'total': 13, 'found': 2,...	False
45	R-HSA-375276	375276	Peptide ligand-binding receptors	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 203, 'found': 3...	{'resource': 'TOTAL', 'total': 76, 'found': 3,...	False
46	R-HSA-9616222	9616222	Transcriptional regulation of granulopoiesis	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 71, 'found': 2,...	{'resource': 'TOTAL', 'total': 27, 'found': 1,...	False
47	R-HSA-5250941	5250941	Negative epigenetic regulation of rRNA expression	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 89, 'found': 2,...	{'resource': 'TOTAL', 'total': 12, 'found': 6,...	False
48	R-HSA-427413	427413	NoRC negatively regulates rRNA expression	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 80, 'found': 2,...	{'resource': 'TOTAL', 'total': 7, 'found': 3, ...	False
49	R-HSA-4086398	4086398	Ca2+ pathway	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 81, 'found': 2,...	{'resource': 'TOTAL', 'total': 27, 'found': 11...	False
50	R-HSA-1300645	1300645	Acrosome Reaction and Sperm:Oocyte Membrane Bi...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 6, 'found': 1, ...	{'resource': 'TOTAL', 'total': 3, 'found': 1, ...	False
51	R-HSA-112314	112314	Neurotransmitter receptors and postsynaptic si...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 231, 'found': 3...	{'resource': 'TOTAL', 'total': 109, 'found': 3...	False
52	R-HSA-5578749	5578749	Transcriptional regulation by small RNAs	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 81, 'found': 2,...	{'resource': 'TOTAL', 'total': 5, 'found': 1, ...	False
53	R-HSA-73854	73854	RNA Polymerase I Promoter Clearance	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 87, 'found': 2,...	{'resource': 'TOTAL', 'total': 10, 'found': 2,...	False
54	R-HSA-73864	73864	RNA Polymerase I Transcription	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 89, 'found': 2,...	{'resource': 'TOTAL', 'total': 14, 'found': 2,...	False
55	R-HSA-1445148	1445148	Translocation of SLC2A4 (GLUT4) to the plasma ...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 79, 'found': 2,...	{'resource': 'TOTAL', 'total': 15, 'found': 2,...	False
56	R-HSA-1912408	1912408	Pre-NOTCH Transcription and Translation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 89, 'found': 2,...	{'resource': 'TOTAL', 'total': 28, 'found': 3,...	False
57	R-HSA-6783783	6783783	Interleukin-10 signaling	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 86, 'found': 2,...	{'resource': 'TOTAL', 'total': 15, 'found': 1,...	False
58	R-HSA-1236394	1236394	Signaling by ERBB4	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 82, 'found': 2,...	{'resource': 'TOTAL', 'total': 52, 'found': 2,...	False
59	R-HSA-2559582	2559582	Senescence-Associated Secretory Phenotype (SASP)	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 91, 'found': 2,...	{'resource': 'TOTAL', 'total': 22, 'found': 2,...	False
60	R-HSA-1500620	1500620	Meiosis	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 92, 'found': 2,...	{'resource': 'TOTAL', 'total': 15, 'found': 2,...	False
61	R-HSA-111957	111957	Cam-PDE 1 activation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 8, 'found': 1, ...	{'resource': 'TOTAL', 'total': 2, 'found': 1, ...	False
62	R-HSA-196025	196025	Formation of annular gap junctions	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 11, 'found': 1,...	{'resource': 'TOTAL', 'total': 2, 'found': 2, ...	False
63	R-HSA-190873	190873	Gap junction degradation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 12, 'found': 1,...	{'resource': 'TOTAL', 'total': 4, 'found': 4, ...	False
64	R-HSA-390450	390450	Folding of actin by CCT/TriC	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 13, 'found': 1,...	{'resource': 'TOTAL', 'total': 2, 'found': 2, ...	False
65	R-HSA-451308	451308	Activation of Ca-permeable Kainate Receptor	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 13, 'found': 1,...	{'resource': 'TOTAL', 'total': 2, 'found': 2, ...	False
66	R-HSA-9619229	9619229	Activation of RAC1 downstream of NMDARs	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 12, 'found': 1,...	{'resource': 'TOTAL', 'total': 6, 'found': 5, ...	False
67	R-HSA-442729	442729	CREB1 phosphorylation through the activation o...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 11, 'found': 1,...	{'resource': 'TOTAL', 'total': 10, 'found': 8,...	False
68	R-HSA-111932	111932	CaMK IV-mediated phosphorylation of CREB	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 13, 'found': 1,...	{'resource': 'TOTAL', 'total': 13, 'found': 10...	False
69	R-HSA-5617472	5617472	Activation of anterior HOX genes in hindbrain ...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 116, 'found': 2...	{'resource': 'TOTAL', 'total': 43, 'found': 31...	False
70	R-HSA-5619507	5619507	Activation of HOX genes during differentiation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 116, 'found': 2...	{'resource': 'TOTAL', 'total': 43, 'found': 31...	False
71	R-HSA-430116	430116	GP1b-IX-V activation signalling	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 12, 'found': 1,...	{'resource': 'TOTAL', 'total': 7, 'found': 5, ...	False
72	R-HSA-2025928	2025928	Calcineurin activates NFAT	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 12, 'found': 1,...	{'resource': 'TOTAL', 'total': 3, 'found': 2, ...	False
73	R-HSA-438064	438064	Post NMDA receptor activation events	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 96, 'found': 2,...	{'resource': 'TOTAL', 'total': 39, 'found': 24...	False
74	R-HSA-451306	451306	Ionotropic activity of kainate receptors	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 14, 'found': 1,...	{'resource': 'TOTAL', 'total': 4, 'found': 2, ...	False
75	R-HSA-3000497	3000497	Scavenging by Class H Receptors	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 15, 'found': 1,...	{'resource': 'TOTAL', 'total': 4, 'found': 2, ...	False
76	R-HSA-442755	442755	Activation of NMDA receptors and postsynaptic ...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 113, 'found': 2...	{'resource': 'TOTAL', 'total': 71, 'found': 29...	False
77	R-HSA-111885	111885	Opioid Signalling	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 112, 'found': 2...	{'resource': 'TOTAL', 'total': 59, 'found': 21...	False
78	R-HSA-428359	428359	Insulin-like Growth Factor-2 mRNA Binding Prot...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 13, 'found': 1,...	{'resource': 'TOTAL', 'total': 3, 'found': 1, ...	False
79	R-HSA-418359	418359	Reduction of cytosolic Ca++ levels	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 15, 'found': 1,...	{'resource': 'TOTAL', 'total': 3, 'found': 1, ...	False
80	R-HSA-390466	390466	Chaperonin-mediated protein folding	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 96, 'found': 2,...	{'resource': 'TOTAL', 'total': 19, 'found': 6,...	False
81	R-HSA-425561	425561	Sodium/Calcium exchangers	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 15, 'found': 1,...	{'resource': 'TOTAL', 'total': 4, 'found': 1, ...	False
82	R-HSA-68875	68875	Mitotic Prophase	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 135, 'found': 2...	{'resource': 'TOTAL', 'total': 34, 'found': 8,...	False
83	R-HSA-391251	391251	Protein folding	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 102, 'found': 2...	{'resource': 'TOTAL', 'total': 28, 'found': 6,...	False
84	R-HSA-8939236	8939236	RUNX1 regulates transcription of genes involve...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 106, 'found': 2...	{'resource': 'TOTAL', 'total': 15, 'found': 3,...	False
85	R-HSA-5689603	5689603	UCH proteinases	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 98, 'found': 2,...	{'resource': 'TOTAL', 'total': 11, 'found': 2,...	False
86	R-HSA-75892	75892	Platelet Adhesion to exposed collagen	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 16, 'found': 1,...	{'resource': 'TOTAL', 'total': 6, 'found': 1, ...	False
87	R-HSA-157579	157579	Telomere Maintenance	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 111, 'found': 2...	{'resource': 'TOTAL', 'total': 34, 'found': 5,...	False
88	R-HSA-3214847	3214847	HATs acetylate histones	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 110, 'found': 2...	{'resource': 'TOTAL', 'total': 15, 'found': 2,...	False
89	R-HSA-418346	418346	Platelet homeostasis	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 117, 'found': 2...	{'resource': 'TOTAL', 'total': 30, 'found': 4,...	False
90	R-HSA-2559580	2559580	Oxidative Stress Induced Senescence	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 114, 'found': 2...	{'resource': 'TOTAL', 'total': 40, 'found': 5,...	False
91	R-HSA-4420097	4420097	VEGFA-VEGFR2 Pathway	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 126, 'found': 2...	{'resource': 'TOTAL', 'total': 79, 'found': 9,...	False
92	R-HSA-9009391	9009391	Extra-nuclear estrogen signaling	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 110, 'found': 2...	{'resource': 'TOTAL', 'total': 38, 'found': 4,...	False
93	R-HSA-194138	194138	Signaling by VEGF	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 137, 'found': 2...	{'resource': 'TOTAL', 'total': 86, 'found': 9,...	False
94	R-HSA-1912422	1912422	Pre-NOTCH Expression and Processing	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 113, 'found': 2...	{'resource': 'TOTAL', 'total': 38, 'found': 3,...	False
95	R-HSA-211000	211000	Gene Silencing by RNA	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 120, 'found': 2...	{'resource': 'TOTAL', 'total': 40, 'found': 1,...	False
96	R-HSA-73886	73886	Chromosome Maintenance	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 138, 'found': 2...	{'resource': 'TOTAL', 'total': 38, 'found': 7,...	False
97	R-HSA-112315	112315	Transmission across Chemical Synapses	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 341, 'found': 3...	{'resource': 'TOTAL', 'total': 163, 'found': 3...	False
98	R-HSA-442720	442720	CREB1 phosphorylation through the activation o...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 17, 'found': 1,...	{'resource': 'TOTAL', 'total': 6, 'found': 2, ...	False
99	R-HSA-8964315	8964315	G beta:gamma signalling through BTK	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 19, 'found': 1,...	{'resource': 'TOTAL', 'total': 3, 'found': 3, ...	False
100	R-HSA-418217	418217	G beta:gamma signalling through PLC beta	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 23, 'found': 1,...	{'resource': 'TOTAL', 'total': 2, 'found': 2, ...	False
101	R-HSA-9617324	9617324	Negative regulation of NMDA receptor-mediated ...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 27, 'found': 1,...	{'resource': 'TOTAL', 'total': 4, 'found': 4, ...	False
102	R-HSA-442982	442982	Ras activation upon Ca2+ influx through NMDA r...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 27, 'found': 1,...	{'resource': 'TOTAL', 'total': 2, 'found': 2, ...	False
103	R-HSA-389957	389957	Prefoldin mediated transfer of substrate to C...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 29, 'found': 1,...	{'resource': 'TOTAL', 'total': 2, 'found': 2, ...	False
104	R-HSA-1296059	1296059	G protein gated Potassium channels	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 31, 'found': 1,...	{'resource': 'TOTAL', 'total': 3, 'found': 3, ...	False
105	R-HSA-997272	997272	Inhibition of voltage gated Ca2+ channels via...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 31, 'found': 1,...	{'resource': 'TOTAL', 'total': 3, 'found': 3, ...	False
106	R-HSA-1296041	1296041	Activation of G protein gated Potassium channels	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 31, 'found': 1,...	{'resource': 'TOTAL', 'total': 3, 'found': 3, ...	False
107	R-HSA-171306	171306	Packaging Of Telomere Ends	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 34, 'found': 1,...	{'resource': 'TOTAL', 'total': 2, 'found': 2, ...	False
108	R-HSA-8964616	8964616	G beta:gamma signalling through CDC42	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 21, 'found': 1,...	{'resource': 'TOTAL', 'total': 6, 'found': 5, ...	False
109	R-HSA-202040	202040	G-protein activation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 26, 'found': 1,...	{'resource': 'TOTAL', 'total': 6, 'found': 5, ...	False
110	R-HSA-392851	392851	Prostacyclin signalling through prostacyclin r...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 23, 'found': 1,...	{'resource': 'TOTAL', 'total': 4, 'found': 3, ...	False
111	R-HSA-392170	392170	ADP signalling through P2Y purinoceptor 12	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 25, 'found': 1,...	{'resource': 'TOTAL', 'total': 4, 'found': 3, ...	False
112	R-HSA-428930	428930	Thromboxane signalling through TP receptor	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 29, 'found': 1,...	{'resource': 'TOTAL', 'total': 8, 'found': 6, ...	False
113	R-HSA-5607763	5607763	CLEC7A (Dectin-1) induces NFAT activation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 18, 'found': 1,...	{'resource': 'TOTAL', 'total': 6, 'found': 4, ...	False
114	R-HSA-400042	400042	Adrenaline,noradrenaline inhibits insulin secr...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 32, 'found': 1,...	{'resource': 'TOTAL', 'total': 6, 'found': 4, ...	False
115	R-HSA-500657	500657	Presynaptic function of Kainate receptors	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 23, 'found': 1,...	{'resource': 'TOTAL', 'total': 2, 'found': 1, ...	False
116	R-HSA-392451	392451	G beta:gamma signalling through PI3Kgamma	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 29, 'found': 1,...	{'resource': 'TOTAL', 'total': 4, 'found': 2, ...	False
117	R-HSA-445095	445095	Interaction between L1 and Ankyrins	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 33, 'found': 1,...	{'resource': 'TOTAL', 'total': 4, 'found': 2, ...	False
118	R-HSA-5576892	5576892	Phase 0 - rapid depolarisation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 34, 'found': 1,...	{'resource': 'TOTAL', 'total': 2, 'found': 1, ...	False
119	R-HSA-418592	418592	ADP signalling through P2Y purinoceptor 1	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 29, 'found': 1,...	{'resource': 'TOTAL', 'total': 7, 'found': 3, ...	False
120	R-HSA-456926	456926	Thrombin signalling through proteinase activat...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 35, 'found': 1,...	{'resource': 'TOTAL', 'total': 15, 'found': 6,...	False
121	R-HSA-2142712	2142712	Synthesis of 12-eicosatetraenoic acid derivatives	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 19, 'found': 1,...	{'resource': 'TOTAL', 'total': 6, 'found': 2, ...	False
122	R-HSA-5689901	5689901	Metalloprotease DUBs	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 32, 'found': 1,...	{'resource': 'TOTAL', 'total': 6, 'found': 2, ...	False
123	R-HSA-9619483	9619483	Activation of AMPK downstream of NMDARs	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 34, 'found': 1,...	{'resource': 'TOTAL', 'total': 3, 'found': 1, ...	False
124	R-HSA-5627117	5627117	RHO GTPases Activate ROCKs	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 24, 'found': 1,...	{'resource': 'TOTAL', 'total': 7, 'found': 2, ...	False
125	R-HSA-2142770	2142770	Synthesis of 15-eicosatetraenoic acid derivatives	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 22, 'found': 1,...	{'resource': 'TOTAL', 'total': 4, 'found': 1, ...	False
126	R-HSA-163615	163615	PKA activation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 23, 'found': 1,...	{'resource': 'TOTAL', 'total': 4, 'found': 1, ...	False
127	R-HSA-2142688	2142688	Synthesis of 5-eicosatetraenoic acids	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 24, 'found': 1,...	{'resource': 'TOTAL', 'total': 4, 'found': 1, ...	False
128	R-HSA-3928663	3928663	EPHA-mediated growth cone collapse	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 33, 'found': 1,...	{'resource': 'TOTAL', 'total': 4, 'found': 1, ...	False
129	R-HSA-3858494	3858494	Beta-catenin independent WNT signaling	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 166, 'found': 2...	{'resource': 'TOTAL', 'total': 51, 'found': 11...	False
130	R-HSA-9018519	9018519	Estrogen-dependent gene expression	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 154, 'found': 2...	{'resource': 'TOTAL', 'total': 66, 'found': 14...	False
131	R-HSA-70221	70221	Glycogen breakdown (glycogenolysis)	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 26, 'found': 1,...	{'resource': 'TOTAL', 'total': 15, 'found': 3,...	False
132	R-HSA-438066	438066	Unblocking of NMDA receptors, glutamate bindin...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 27, 'found': 1,...	{'resource': 'TOTAL', 'total': 5, 'found': 1, ...	False
133	R-HSA-5625900	5625900	RHO GTPases activate CIT	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 23, 'found': 1,...	{'resource': 'TOTAL', 'total': 6, 'found': 1, ...	False
134	R-HSA-140837	140837	Intrinsic Pathway of Fibrin Clot Formation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 26, 'found': 1,...	{'resource': 'TOTAL', 'total': 24, 'found': 4,...	False
135	R-HSA-180024	180024	DARPP-32 events	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 35, 'found': 1,...	{'resource': 'TOTAL', 'total': 12, 'found': 2,...	False
136	R-HSA-416572	416572	Sema4D induced cell migration and growth-cone ...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 24, 'found': 1,...	{'resource': 'TOTAL', 'total': 7, 'found': 1, ...	False
137	R-HSA-111931	111931	PKA-mediated phosphorylation of CREB	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 26, 'found': 1,...	{'resource': 'TOTAL', 'total': 7, 'found': 1, ...	False
138	R-HSA-418990	418990	Adherens junctions interactions	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 35, 'found': 1,...	{'resource': 'TOTAL', 'total': 16, 'found': 2,...	False
139	R-HSA-418360	418360	Platelet calcium homeostasis	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 35, 'found': 1,...	{'resource': 'TOTAL', 'total': 8, 'found': 1, ...	False
140	R-HSA-420092	420092	Glucagon-type ligand receptors	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 35, 'found': 1,...	{'resource': 'TOTAL', 'total': 8, 'found': 1, ...	False
141	R-HSA-8876725	8876725	Protein methylation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 19, 'found': 1,...	{'resource': 'TOTAL', 'total': 9, 'found': 1, ...	False
142	R-HSA-1187000	1187000	Fertilization	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 31, 'found': 1,...	{'resource': 'TOTAL', 'total': 9, 'found': 1, ...	False
143	R-HSA-446353	446353	Cell-extracellular matrix interactions	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 19, 'found': 1,...	{'resource': 'TOTAL', 'total': 10, 'found': 1,...	False
144	R-HSA-3928664	3928664	Ephrin signaling	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 23, 'found': 1,...	{'resource': 'TOTAL', 'total': 11, 'found': 1,...	False
145	R-HSA-2559583	2559583	Cellular Senescence	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 200, 'found': 2...	{'resource': 'TOTAL', 'total': 90, 'found': 8,...	False
146	R-HSA-5218921	5218921	VEGFR2 mediated cell proliferation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 31, 'found': 1,...	{'resource': 'TOTAL', 'total': 12, 'found': 1,...	False
147	R-HSA-400685	400685	Sema4D in semaphorin signaling	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 30, 'found': 1,...	{'resource': 'TOTAL', 'total': 13, 'found': 1,...	False
148	R-HSA-983231	983231	Factors involved in megakaryocyte development ...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 194, 'found': 2...	{'resource': 'TOTAL', 'total': 43, 'found': 3,...	False
149	R-HSA-500792	500792	GPCR ligand binding	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 606, 'found': 4...	{'resource': 'TOTAL', 'total': 186, 'found': 4...	False
150	R-HSA-373076	373076	Class A/1 (Rhodopsin-like receptors)	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 412, 'found': 3...	{'resource': 'TOTAL', 'total': 159, 'found': 3...	False
151	R-HSA-9006934	9006934	Signaling by Receptor Tyrosine Kinases	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 617, 'found': 4...	{'resource': 'TOTAL', 'total': 744, 'found': 1...	False
152	R-HSA-9711123	9711123	Cellular response to chemical stress	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 208, 'found': 2...	{'resource': 'TOTAL', 'total': 71, 'found': 3,...	False
153	R-HSA-389958	389958	Cooperation of Prefoldin and TriC/CCT in acti...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 37, 'found': 1,...	{'resource': 'TOTAL', 'total': 6, 'found': 4, ...	False
154	R-HSA-203615	203615	eNOS activation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 37, 'found': 1,...	{'resource': 'TOTAL', 'total': 20, 'found': 9,...	False
155	R-HSA-1474151	1474151	Tetrahydrobiopterin (BH4) synthesis, recycling...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 37, 'found': 1,...	{'resource': 'TOTAL', 'total': 16, 'found': 2,...	False
156	R-HSA-201681	201681	TCF dependent signaling in response to WNT	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 216, 'found': 2...	{'resource': 'TOTAL', 'total': 71, 'found': 2,...	False
157	R-HSA-1296065	1296065	Inwardly rectifying K+ channels	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 38, 'found': 1,...	{'resource': 'TOTAL', 'total': 7, 'found': 3, ...	False
158	R-HSA-397795	397795	G-protein beta:gamma signalling	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 39, 'found': 1,...	{'resource': 'TOTAL', 'total': 15, 'found': 12...	False
159	R-HSA-9013424	9013424	RHOV GTPase cycle	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 39, 'found': 1,...	{'resource': 'TOTAL', 'total': 2, 'found': 1, ...	False
160	R-HSA-442742	442742	CREB1 phosphorylation through NMDA receptor-me...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 39, 'found': 1,...	{'resource': 'TOTAL', 'total': 7, 'found': 2, ...	False
161	R-HSA-9022692	9022692	Regulation of MECP2 expression and activity	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 39, 'found': 1,...	{'resource': 'TOTAL', 'total': 14, 'found': 3,...	False
162	R-HSA-110330	110330	Recognition and association of DNA glycosylase...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 39, 'found': 1,...	{'resource': 'TOTAL', 'total': 10, 'found': 2,...	False
163	R-HSA-1855204	1855204	Synthesis of IP3 and IP4 in the cytosol	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 39, 'found': 1,...	{'resource': 'TOTAL', 'total': 12, 'found': 1,...	False
164	R-HSA-390522	390522	Striated Muscle Contraction	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 40, 'found': 1,...	{'resource': 'TOTAL', 'total': 4, 'found': 4, ...	False
165	R-HSA-392518	392518	Signal amplification	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 40, 'found': 1,...	{'resource': 'TOTAL', 'total': 19, 'found': 12...	False
166	R-HSA-5696394	5696394	DNA Damage Recognition in GG-NER	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 40, 'found': 1,...	{'resource': 'TOTAL', 'total': 5, 'found': 1, ...	False
167	R-HSA-163359	163359	Glucagon signaling in metabolic regulation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 40, 'found': 1,...	{'resource': 'TOTAL', 'total': 6, 'found': 1, ...	False
168	R-HSA-5663213	5663213	RHO GTPases Activate WASPs and WAVEs	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 41, 'found': 1,...	{'resource': 'TOTAL', 'total': 10, 'found': 4,...	False
169	R-HSA-202131	202131	Metabolism of nitric oxide: NOS3 activation an...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 41, 'found': 1,...	{'resource': 'TOTAL', 'total': 26, 'found': 9,...	False
170	R-HSA-6814122	6814122	Cooperation of PDCL (PhLP1) and TRiC/CCT in G-...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 41, 'found': 1,...	{'resource': 'TOTAL', 'total': 11, 'found': 2,...	False
171	R-HSA-5673000	5673000	RAF activation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 41, 'found': 1,...	{'resource': 'TOTAL', 'total': 12, 'found': 1,...	False
172	R-HSA-112316	112316	Neuronal System	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 487, 'found': 3...	{'resource': 'TOTAL', 'total': 216, 'found': 3...	False
173	R-HSA-110328	110328	Recognition and association of DNA glycosylase...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 42, 'found': 1,...	{'resource': 'TOTAL', 'total': 21, 'found': 1,...	False
174	R-HSA-111997	111997	CaM pathway	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 43, 'found': 1,...	{'resource': 'TOTAL', 'total': 24, 'found': 14...	False
175	R-HSA-111933	111933	Calmodulin induced events	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 43, 'found': 1,...	{'resource': 'TOTAL', 'total': 23, 'found': 13...	False
176	R-HSA-8982491	8982491	Glycogen metabolism	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 43, 'found': 1,...	{'resource': 'TOTAL', 'total': 39, 'found': 3,...	False
177	R-HSA-5218920	5218920	VEGFR2 mediated vascular permeability	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 44, 'found': 1,...	{'resource': 'TOTAL', 'total': 15, 'found': 7,...	False
178	R-HSA-110331	110331	Cleavage of the damaged purine	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 45, 'found': 1,...	{'resource': 'TOTAL', 'total': 9, 'found': 2, ...	False
179	R-HSA-9035034	9035034	RHOF GTPase cycle	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 46, 'found': 1,...	{'resource': 'TOTAL', 'total': 3, 'found': 1, ...	False
180	R-HSA-9648002	9648002	RAS processing	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 46, 'found': 1,...	{'resource': 'TOTAL', 'total': 21, 'found': 5,...	False
181	R-HSA-73927	73927	Depurination	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 46, 'found': 1,...	{'resource': 'TOTAL', 'total': 19, 'found': 4,...	False
182	R-HSA-111996	111996	Ca-dependent events	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 48, 'found': 1,...	{'resource': 'TOTAL', 'total': 27, 'found': 14...	False
183	R-HSA-5674135	5674135	MAP2K and MAPK activation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 49, 'found': 1,...	{'resource': 'TOTAL', 'total': 12, 'found': 8,...	False
184	R-HSA-991365	991365	Activation of GABAB receptors	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 49, 'found': 1,...	{'resource': 'TOTAL', 'total': 8, 'found': 3, ...	False
185	R-HSA-977444	977444	GABA B receptor activation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 49, 'found': 1,...	{'resource': 'TOTAL', 'total': 9, 'found': 3, ...	False
186	R-HSA-381676	381676	Glucagon-like Peptide-1 (GLP1) regulates insul...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 49, 'found': 1,...	{'resource': 'TOTAL', 'total': 11, 'found': 3,...	False
187	R-HSA-4839726	4839726	Chromatin organization	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 256, 'found': 2...	{'resource': 'TOTAL', 'total': 85, 'found': 10...	False
188	R-HSA-3247509	3247509	Chromatin modifying enzymes	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 256, 'found': 2...	{'resource': 'TOTAL', 'total': 85, 'found': 10...	False
189	R-HSA-350562	350562	Regulation of ornithine decarboxylase (ODC)	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 51, 'found': 1,...	{'resource': 'TOTAL', 'total': 4, 'found': 3, ...	False
190	R-HSA-110329	110329	Cleavage of the damaged pyrimidine	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 51, 'found': 1,...	{'resource': 'TOTAL', 'total': 20, 'found': 1,...	False
191	R-HSA-73928	73928	Depyrimidination	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 51, 'found': 1,...	{'resource': 'TOTAL', 'total': 41, 'found': 2,...	False
192	R-HSA-3928662	3928662	EPHB-mediated forward signaling	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 51, 'found': 1,...	{'resource': 'TOTAL', 'total': 26, 'found': 1,...	False
193	R-HSA-202733	202733	Cell surface interactions at the vascular wall	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 257, 'found': 2...	{'resource': 'TOTAL', 'total': 65, 'found': 1,...	False
194	R-HSA-157118	157118	Signaling by NOTCH	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 258, 'found': 2...	{'resource': 'TOTAL', 'total': 154, 'found': 3...	False
195	R-HSA-190828	190828	Gap junction trafficking	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 52, 'found': 1,...	{'resource': 'TOTAL', 'total': 20, 'found': 4,...	False
196	R-HSA-432040	432040	Vasopressin regulates renal water homeostasis ...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 52, 'found': 1,...	{'resource': 'TOTAL', 'total': 15, 'found': 3,...	False
197	R-HSA-1489509	1489509	DAG and IP3 signaling	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 53, 'found': 1,...	{'resource': 'TOTAL', 'total': 28, 'found': 14...	False
198	R-HSA-3214858	3214858	RMTs methylate histone arginines	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 53, 'found': 1,...	{'resource': 'TOTAL', 'total': 22, 'found': 4,...	False
199	R-HSA-76009	76009	Platelet Aggregation (Plug Formation)	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 53, 'found': 1,...	{'resource': 'TOTAL', 'total': 27, 'found': 1,...	False
200	R-HSA-606279	606279	Deposition of new CENPA-containing nucleosomes...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 54, 'found': 1,...	{'resource': 'TOTAL', 'total': 4, 'found': 2, ...	False
201	R-HSA-774815	774815	Nucleosome assembly	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 54, 'found': 1,...	{'resource': 'TOTAL', 'total': 4, 'found': 2, ...	False
202	R-HSA-2514859	2514859	Inactivation, recovery and regulation of the p...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 54, 'found': 1,...	{'resource': 'TOTAL', 'total': 19, 'found': 3,...	False
203	R-HSA-437239	437239	Recycling pathway of L1	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 55, 'found': 1,...	{'resource': 'TOTAL', 'total': 14, 'found': 3,...	False
204	R-HSA-3928665	3928665	EPH-ephrin mediated repulsion of cells	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 55, 'found': 1,...	{'resource': 'TOTAL', 'total': 9, 'found': 1, ...	False
205	R-HSA-157858	157858	Gap junction trafficking and regulation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 56, 'found': 1,...	{'resource': 'TOTAL', 'total': 24, 'found': 4,...	False
206	R-HSA-2514856	2514856	The phototransduction cascade	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 59, 'found': 1,...	{'resource': 'TOTAL', 'total': 27, 'found': 3,...	False
207	R-HSA-416476	416476	G alpha (q) signalling events	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 283, 'found': 2...	{'resource': 'TOTAL', 'total': 35, 'found': 8,...	False
208	R-HSA-418597	418597	G alpha (z) signalling events	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 62, 'found': 1,...	{'resource': 'TOTAL', 'total': 13, 'found': 4,...	False
209	R-HSA-1221632	1221632	Meiotic synapsis	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 62, 'found': 1,...	{'resource': 'TOTAL', 'total': 6, 'found': 1, ...	False
210	R-HSA-73929	73929	Base-Excision Repair, AP Site Formation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 62, 'found': 1,...	{'resource': 'TOTAL', 'total': 62, 'found': 6,...	False
211	R-HSA-5688426	5688426	Deubiquitination	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 289, 'found': 2...	{'resource': 'TOTAL', 'total': 77, 'found': 6,...	False
212	R-HSA-3214815	3214815	HDACs deacetylate histones	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 63, 'found': 1,...	{'resource': 'TOTAL', 'total': 5, 'found': 4, ...	False
213	R-HSA-1266738	1266738	Developmental Biology	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 1262, 'found': ...	{'resource': 'TOTAL', 'total': 556, 'found': 4...	False
214	R-HSA-422475	422475	Axon guidance	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 584, 'found': 3...	{'resource': 'TOTAL', 'total': 298, 'found': 1...	False
215	R-HSA-5578775	5578775	Ion homeostasis	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 64, 'found': 1,...	{'resource': 'TOTAL', 'total': 16, 'found': 3,...	False
216	R-HSA-9662361	9662361	Sensory processing of sound by outer hair cell...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 64, 'found': 1,...	{'resource': 'TOTAL', 'total': 8, 'found': 1, ...	False
217	R-HSA-8978934	8978934	Metabolism of cofactors	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 66, 'found': 1,...	{'resource': 'TOTAL', 'total': 28, 'found': 2,...	False
218	R-HSA-112043	112043	PLC beta mediated events	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 67, 'found': 1,...	{'resource': 'TOTAL', 'total': 32, 'found': 14...	False
219	R-HSA-977443	977443	GABA receptor activation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 67, 'found': 1,...	{'resource': 'TOTAL', 'total': 12, 'found': 3,...	False
220	R-HSA-421270	421270	Cell-cell junction organization	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 67, 'found': 1,...	{'resource': 'TOTAL', 'total': 21, 'found': 2,...	False
221	R-HSA-445717	445717	Aquaporin-mediated transport	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 68, 'found': 1,...	{'resource': 'TOTAL', 'total': 25, 'found': 3,...	False
222	R-HSA-373755	373755	Semaphorin interactions	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 70, 'found': 1,...	{'resource': 'TOTAL', 'total': 41, 'found': 1,...	False
223	R-HSA-2262752	2262752	Cellular responses to stress	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 948, 'found': 4...	{'resource': 'TOTAL', 'total': 381, 'found': 1...	False
224	R-HSA-936837	936837	Ion transport by P-type ATPases	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 71, 'found': 1,...	{'resource': 'TOTAL', 'total': 16, 'found': 1,...	False
225	R-HSA-2559586	2559586	DNA Damage/Telomere Stress Induced Senescence	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 71, 'found': 1,...	{'resource': 'TOTAL', 'total': 18, 'found': 1,...	False
226	R-HSA-112040	112040	G-protein mediated events	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 72, 'found': 1,...	{'resource': 'TOTAL', 'total': 41, 'found': 14...	False
227	R-HSA-9675108	9675108	Nervous system development	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 620, 'found': 3...	{'resource': 'TOTAL', 'total': 324, 'found': 1...	False
228	R-HSA-8953897	8953897	Cellular responses to stimuli	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 966, 'found': 4...	{'resource': 'TOTAL', 'total': 412, 'found': 1...	False
229	R-HSA-5673001	5673001	RAF/MAP kinase cascade	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 322, 'found': 2...	{'resource': 'TOTAL', 'total': 75, 'found': 15...	False
230	R-HSA-9662360	9662360	Sensory processing of sound by inner hair cell...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 76, 'found': 1,...	{'resource': 'TOTAL', 'total': 7, 'found': 1, ...	False
231	R-HSA-5684996	5684996	MAPK1/MAPK3 signaling	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 329, 'found': 2...	{'resource': 'TOTAL', 'total': 82, 'found': 15...	False
232	R-HSA-3000178	3000178	ECM proteoglycans	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 79, 'found': 1,...	{'resource': 'TOTAL', 'total': 23, 'found': 1,...	False
233	R-HSA-351202	351202	Metabolism of polyamines	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 80, 'found': 1,...	{'resource': 'TOTAL', 'total': 17, 'found': 3,...	False
234	R-HSA-416482	416482	G alpha (12/13) signalling events	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 85, 'found': 1,...	{'resource': 'TOTAL', 'total': 15, 'found': 4,...	False
235	R-HSA-9659379	9659379	Sensory processing of sound	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 87, 'found': 1,...	{'resource': 'TOTAL', 'total': 13, 'found': 2,...	False
236	R-HSA-2151201	2151201	Transcriptional activation of mitochondrial bi...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 88, 'found': 1,...	{'resource': 'TOTAL', 'total': 32, 'found': 1,...	False
237	R-HSA-1483249	1483249	Inositol phosphate metabolism	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 90, 'found': 1,...	{'resource': 'TOTAL', 'total': 71, 'found': 1,...	False
238	R-HSA-1168372	1168372	Downstream signaling events of B Cell Receptor...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 91, 'found': 1,...	{'resource': 'TOTAL', 'total': 15, 'found': 2,...	False
239	R-HSA-5696399	5696399	Global Genome Nucleotide Excision Repair (GG-NER)	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 92, 'found': 1,...	{'resource': 'TOTAL', 'total': 20, 'found': 1,...	False
240	R-HSA-392499	392499	Metabolism of proteins	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 2205, 'found': ...	{'resource': 'TOTAL', 'total': 798, 'found': 1...	False
241	R-HSA-446728	446728	Cell junction organization	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 94, 'found': 1,...	{'resource': 'TOTAL', 'total': 37, 'found': 3,...	False
242	R-HSA-73894	73894	DNA Repair	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 369, 'found': 2...	{'resource': 'TOTAL', 'total': 332, 'found': 7...	False
243	R-HSA-73884	73884	Base Excision Repair	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 99, 'found': 1,...	{'resource': 'TOTAL', 'total': 105, 'found': 6...	False
244	R-HSA-373080	373080	Class B/2 (Secretin family receptors)	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 99, 'found': 1,...	{'resource': 'TOTAL', 'total': 20, 'found': 1,...	False
245	R-HSA-8986944	8986944	Transcriptional Regulation by MECP2	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 100, 'found': 1...	{'resource': 'TOTAL', 'total': 77, 'found': 3,...	False
246	R-HSA-5683057	5683057	MAPK family signaling cascades	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 380, 'found': 2...	{'resource': 'TOTAL', 'total': 122, 'found': 1...	False
247	R-HSA-74160	74160	Gene expression (Transcription)	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 1855, 'found': ...	{'resource': 'TOTAL', 'total': 1000, 'found': ...	False
248	R-HSA-983695	983695	Antigen activates B Cell Receptor (BCR) leadin...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 103, 'found': 1...	{'resource': 'TOTAL', 'total': 25, 'found': 1,...	False
249	R-HSA-422356	422356	Regulation of insulin secretion	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 106, 'found': 1...	{'resource': 'TOTAL', 'total': 34, 'found': 7,...	False
250	R-HSA-1296071	1296071	Potassium Channels	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 107, 'found': 1...	{'resource': 'TOTAL', 'total': 19, 'found': 3,...	False
251	R-HSA-8957275	8957275	Post-translational protein phosphorylation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 109, 'found': 1...	{'resource': 'TOTAL', 'total': 1, 'found': 1, ...	False
252	R-HSA-68886	68886	M Phase	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 416, 'found': 2...	{'resource': 'TOTAL', 'total': 91, 'found': 8,...	False
253	R-HSA-2672351	2672351	Stimuli-sensing channels	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 119, 'found': 1...	{'resource': 'TOTAL', 'total': 28, 'found': 1,...	False
254	R-HSA-5696398	5696398	Nucleotide Excision Repair	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 119, 'found': 1...	{'resource': 'TOTAL', 'total': 37, 'found': 1,...	False
255	R-HSA-5607764	5607764	CLEC7A (Dectin-1) signaling	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 120, 'found': 1...	{'resource': 'TOTAL', 'total': 45, 'found': 4,...	False
256	R-HSA-212436	212436	Generic Transcription Pathway	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 1555, 'found': ...	{'resource': 'TOTAL', 'total': 824, 'found': 2...	False
257	R-HSA-381426	381426	Regulation of Insulin-like Growth Factor (IGF)...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 127, 'found': 1...	{'resource': 'TOTAL', 'total': 14, 'found': 1,...	False
258	R-HSA-1592230	1592230	Mitochondrial biogenesis	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 128, 'found': 1...	{'resource': 'TOTAL', 'total': 36, 'found': 1,...	False
259	R-HSA-2871809	2871809	FCERI mediated Ca+2 mobilization	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 129, 'found': 1...	{'resource': 'TOTAL', 'total': 11, 'found': 4,...	False
260	R-HSA-373760	373760	L1CAM interactions	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 130, 'found': 1...	{'resource': 'TOTAL', 'total': 54, 'found': 5,...	False
261	R-HSA-1500931	1500931	Cell-Cell communication	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 133, 'found': 1...	{'resource': 'TOTAL', 'total': 60, 'found': 3,...	False
262	R-HSA-5653656	5653656	Vesicle-mediated transport	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 824, 'found': 3...	{'resource': 'TOTAL', 'total': 252, 'found': 1...	False
263	R-HSA-5576891	5576891	Cardiac conduction	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 138, 'found': 1...	{'resource': 'TOTAL', 'total': 27, 'found': 4,...	False
264	R-HSA-9012999	9012999	RHO GTPase cycle	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 460, 'found': 2...	{'resource': 'TOTAL', 'total': 91, 'found': 2,...	False
265	R-HSA-163685	163685	Integration of energy metabolism	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 145, 'found': 1...	{'resource': 'TOTAL', 'total': 62, 'found': 8,...	False
266	R-HSA-6798695	6798695	Neutrophil degranulation	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 480, 'found': 2...	{'resource': 'TOTAL', 'total': 10, 'found': 2,...	False
267	R-HSA-5663220	5663220	RHO GTPases Activate Formins	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 149, 'found': 1...	{'resource': 'TOTAL', 'total': 27, 'found': 8,...	False
268	R-HSA-2029482	2029482	Regulation of actin dynamics for phagocytic cu...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 158, 'found': 1...	{'resource': 'TOTAL', 'total': 24, 'found': 6,...	False
269	R-HSA-73857	73857	RNA Polymerase II Transcription	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 1694, 'found': ...	{'resource': 'TOTAL', 'total': 885, 'found': 2...	False
270	R-HSA-8856828	8856828	Clathrin-mediated endocytosis	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 161, 'found': 1...	{'resource': 'TOTAL', 'total': 35, 'found': 11...	False
271	R-HSA-425393	425393	Transport of inorganic cations/anions and amin...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 164, 'found': 1...	{'resource': 'TOTAL', 'total': 75, 'found': 1,...	False
272	R-HSA-2142753	2142753	Arachidonic acid metabolism	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 165, 'found': 1...	{'resource': 'TOTAL', 'total': 77, 'found': 4,...	False
273	R-HSA-2173782	2173782	Binding and Uptake of Ligands by Scavenger Rec...	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 167, 'found': 1...	{'resource': 'TOTAL', 'total': 33, 'found': 2,...	False
274	R-HSA-2187338	2187338	Visual phototransduction	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 169, 'found': 1...	{'resource': 'TOTAL', 'total': 92, 'found': 3,...	False
275	R-HSA-418555	418555	G alpha (s) signalling events	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 172, 'found': 1...	{'resource': 'TOTAL', 'total': 18, 'found': 4,...	False
276	R-HSA-168249	168249	Innate Immune System	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 1334, 'found': ...	{'resource': 'TOTAL', 'total': 710, 'found': 1...	False
277	R-HSA-983705	983705	Signaling by the B Cell Receptor (BCR)	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 189, 'found': 1...	{'resource': 'TOTAL', 'total': 44, 'found': 3,...	False
278	R-HSA-2029480	2029480	Fcgamma receptor (FCGR) dependent phagocytosis	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 193, 'found': 1...	{'resource': 'TOTAL', 'total': 42, 'found': 6,...	False
279	R-HSA-5621481	5621481	C-type lectin receptors (CLRs)	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 203, 'found': 1...	{'resource': 'TOTAL', 'total': 68, 'found': 4,...	False
280	R-HSA-5689880	5689880	Ub-specific processing proteases	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 206, 'found': 1...	{'resource': 'TOTAL', 'total': 40, 'found': 2,...	False
281	R-HSA-983712	983712	Ion channel transport	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 206, 'found': 1...	{'resource': 'TOTAL', 'total': 45, 'found': 2,...	False
282	R-HSA-69278	69278	Cell Cycle, Mitotic	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 596, 'found': 2...	{'resource': 'TOTAL', 'total': 350, 'found': 8...	False
283	R-HSA-2454202	2454202	Fc epsilon receptor (FCERI) signaling	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 235, 'found': 1...	{'resource': 'TOTAL', 'total': 65, 'found': 4,...	False
284	R-HSA-449147	449147	Signaling by Interleukins	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 643, 'found': 2...	{'resource': 'TOTAL', 'total': 493, 'found': 1...	False
285	R-HSA-199991	199991	Membrane Trafficking	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 665, 'found': 2...	{'resource': 'TOTAL', 'total': 219, 'found': 1...	False
286	R-HSA-9709957	9709957	Sensory Perception	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 681, 'found': 2...	{'resource': 'TOTAL', 'total': 107, 'found': 5...	False
287	R-HSA-597592	597592	Post-translational protein modification	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 1598, 'found': ...	{'resource': 'TOTAL', 'total': 526, 'found': 8...	False
288	R-HSA-1640170	1640170	Cell Cycle	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 734, 'found': 2...	{'resource': 'TOTAL', 'total': 449, 'found': 1...	False
289	R-HSA-1474244	1474244	Extracellular matrix organization	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	True	{'resource': 'TOTAL', 'total': 329, 'found': 1...	{'resource': 'TOTAL', 'total': 319, 'found': 1...	False
290	R-HSA-1852241	1852241	Organelle biogenesis and maintenance	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 336, 'found': 1...	{'resource': 'TOTAL', 'total': 86, 'found': 1,...	False
291	R-HSA-168256	168256	Immune System	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 2681, 'found': ...	{'resource': 'TOTAL', 'total': 1623, 'found': ...	False
292	R-HSA-9006925	9006925	Intracellular signaling by second messengers	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 366, 'found': 1...	{'resource': 'TOTAL', 'total': 114, 'found': 1...	False
293	R-HSA-196854	196854	Metabolism of vitamins and cofactors	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 377, 'found': 1...	{'resource': 'TOTAL', 'total': 206, 'found': 2...	False
294	R-HSA-425407	425407	SLC-mediated transmembrane transport	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 415, 'found': 1...	{'resource': 'TOTAL', 'total': 191, 'found': 1...	False
295	R-HSA-8978868	8978868	Fatty acid metabolism	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 428, 'found': 1...	{'resource': 'TOTAL', 'total': 217, 'found': 4...	False
296	R-HSA-382551	382551	Transport of small molecules	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 958, 'found': 2...	{'resource': 'TOTAL', 'total': 442, 'found': 6...	False
297	R-HSA-71387	71387	Metabolism of carbohydrates	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 456, 'found': 1...	{'resource': 'TOTAL', 'total': 243, 'found': 3...	False
298	R-HSA-1280215	1280215	Cytokine Signaling in Immune system	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 1092, 'found': ...	{'resource': 'TOTAL', 'total': 708, 'found': 1...	False
299	R-HSA-71291	71291	Metabolism of amino acids and derivatives	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 661, 'found': 1...	{'resource': 'TOTAL', 'total': 285, 'found': 3...	False
300	R-HSA-8953854	8953854	Metabolism of RNA	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 782, 'found': 1...	{'resource': 'TOTAL', 'total': 187, 'found': 1...	False
301	R-HSA-1280218	1280218	Adaptive Immune System	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 1004, 'found': ...	{'resource': 'TOTAL', 'total': 264, 'found': 3...	False
302	R-HSA-556833	556833	Metabolism of lipids	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 1437, 'found': ...	{'resource': 'TOTAL', 'total': 949, 'found': 4...	False
303	R-HSA-1430728	1430728	Metabolism	{'dbId': 48887, 'taxId': '9606', 'name': 'Homo...	False	{'resource': 'TOTAL', 'total': 3633, 'found': ...	{'resource': 'TOTAL', 'total': 2250, 'found': ...	False