cameo reuses and extends model data structures defined by cobrapy (COnstraints-Based Reconstruction and Analysis tool for Python). So, in addition to following this quick start guide and other cameo tutorials, we encourage you to explore cobrapy's documentation as well.
Loading a model is easy. Just import the ~cameo.io.load_model
function.
from cameo import load_model
For example, load the most current genome-scale metabolic reconstruction of Escherichia coli.
model = load_model("iJO1366")
Models, reactions, metabolites, etc., provide return HTML when evaluated in Jupyter notebooks and can thus be easily inspected.
model
Name | iJO1366 |
Number of metabolites | 1805 |
Number of reactions | 2583 |
Reactions | 4crsol_c --> 5drib_c --> aacald_c --> amob_c --> mththf_c --> oxam_c --> 0.012379 nh4_c + 0.000223 thf_c + 0.499149 ala__L_c + 0.000674 cu2_c + 0.001345 murein3p3p_p + 0.000223 ribflv_c + 0.000223 enter_c + 0.140101 utp_c + 0.000279 accoa_c + 0.000223 fad_c + 0.008151 colipa_e + 0.000223 gthrd_c + 0.214798 pro__L_c + 0.234232 asn__L_c + 0.000223 mql8_c + 2e-06 btn_c + 0.00118 clpn181_p + 0.000112 nadp_c + 0.000223 hemeO_c + 0.025612 dctp_c + 0.154187 glycogen_c + 0.001961 pg181_p + 7e-06 mocogdp_c + 7e-06 mococdp_c + 0.000673 murein4px4px4p_p + 0.003805 pg161_p + 0.006744 spmd_c + 0.129799 ctp_c + 0.282306 ile__L_c + 9.8e-05 succoa_c + 0.000324 zn2_c + 0.005381 murein4p4p_p + 0.005448 murein4px4p_p + 0.000223 5mthf_c + 0.000307 ni2_c + 0.595297 gly_c + 0.004952 cl_c + 0.000223 q8h2_c + 0.000223 mlthf_c + 0.024805 dttp_c + 0.004892 pg160_p + 0.234232 asp__L_c + 48.752916 h2o_c + 0.004126 so4_c + 0.007428 fe3_c + 0.006388 fe2_c + 0.000605 murein3px4p_p + 0.180021 phe__L_c + 0.255712 gln__L_c + 0.000658 mn2_c + 0.024732 pe161_p + 0.000223 chor_c + 0.000223 pydx5p_c + 0.000223 10fthf_c + 0.209121 gtp_c + 0.000223 adocbl_c + 0.012747 pe181_p + 0.002944 clpn160_p + 0.333448 lys__L_c + 0.092056 his__L_c + 0.000116 bmocogdp_c + 0.004952 ca2_c + 0.03327 ptrc_c + 0.18569 k_c + 0.031798 pe160_p + 0.000223 sheme_c + 0.000223 pheme_c + 0.002288 pg181_c + 3e-06 lipopb_c + 0.255712 glu__L_c + 2.4e-05 cobalt2_c + 2.5e-05 2fe2s_c + 0.149336 met__L_c + 0.012366 pe160_c + 0.088988 cys__L_c + 0.000223 thmpp_c + 0.001787 nad_c + 0.000168 coa_c + 0.209684 ser__L_c + 5.5e-05 udcpdp_c + 0.005707 pg160_c + 0.004439 pg161_c + 0.000223 2dmmql8_c + 0.004957 pe181_c + 0.008253 mg2_c + 0.009618 pe161_c + 0.28742 arg__L_c + 54.119975 atp_c + 0.055234 trp__L_c + 3.1e-05 malcoa_c + 0.246506 thr__L_c + 0.024805 datp_c + 4.5e-05 nadh_c + 0.025612 dgtp_c + 0.411184 val__L_c + 0.000335 nadph_c + 0.00229 clpn161_p + 0.000248 4fe4s_c + 0.133993 tyr__L_c + 0.437778 leu__L_c + 0.000223 amet_c + 7e-06 mobd_c --> 0.749831 ppi_c + 53.95 h_c + 53.95 adp_c + 53.945874 pi_c 0.000691 mn2_c + 0.000223 pydx5p_c + 0.006715 fe2_c + 0.513689 ala__L_c + 0.027017 dctp_c + 0.137896 tyr__L_c + 0.000223 ribflv_c + 0.144104 utp_c + 0.094738 his__L_c + 0.215096 gtp_c + 0.000223 fad_c + 0.000122 bmocogdp_c + 0.423162 val__L_c + 0.26316 glu__L_c + 2.5e-05 cobalt2_c + 0.09158 cys__L_c + 7e-06 mobd_c + 2e-06 btn_c + 0.195193 k_c + 0.045946 pe160_p + 0.241055 asn__L_c + 0.000223 sheme_c + 0.00026 4fe4s_c + 0.013013 nh4_c + 0.005205 ca2_c + 2.6e-05 2fe2s_c + 0.000447 nadp_c + 0.253687 thr__L_c + 0.133508 ctp_c + 0.001831 nad_c + 0.056843 trp__L_c + 0.215792 ser__L_c + 0.013894 murein5px4p_p + 0.000709 cu2_c + 0.343161 lys__L_c + 0.153686 met__L_c + 0.000576 coa_c + 0.019456 kdo2lipid4_e + 0.290529 ile__L_c + 0.008675 mg2_c + 54.124831 atp_c + 0.054154 pe161_c + 0.000223 2ohph_c + 0.000223 thmpp_c + 0.000223 thf_c + 5.5e-05 udcpdp_c + 0.000323 ni2_c + 0.612638 gly_c + 0.005205 cl_c + 0.000223 mlthf_c + 0.026166 dttp_c + 0.026166 datp_c + 0.241055 asp__L_c + 0.26316 gln__L_c + 0.004338 so4_c + 0.000223 10fthf_c + 0.027017 dgtp_c + 0.007808 fe3_c + 48.601527 h2o_c + 0.000341 zn2_c + 0.000223 pheme_c + 0.185265 phe__L_c + 0.017868 pe160_c + 0.221055 pro__L_c + 0.295792 arg__L_c + 0.02106 pe161_p + 0.450531 leu__L_c + 0.000223 amet_c --> 0.773903 ppi_c + 53.945662 pi_c + 53.95 h_c + 53.95 adp_c 12ppd__R_e --> 12ppd__S_e --> 14glucan_e --> 15dap_e --> 23camp_e --> 23ccmp_e --> 23cgmp_e --> 23cump_e --> 23dappa_e --> 26dap__M_e --> 2ddglcn_e --> 34dhpac_e --> 3amp_e --> 3cmp_e --> 3gmp_e --> 3hcinnm_e --> 3hpp_e --> 3hpppn_e --> 3ump_e --> 4abut_e --> 4hoxpacd_e --> 5dglcn_e --> 5mtr_e --> LalaDglu_e --> LalaDgluMdap_e --> LalaDgluMdapDala_e --> LalaLglu_e --> ac_e --> acac_e --> acald_e --> acgal_e --> acgal1p_e --> acgam_e --> acgam1p_e --> acmana_e --> acmum_e --> acnam_e --> acolipa_e --> acser_e --> ade_e --> adn_e --> adocbl_e --> ag_e --> agm_e --> akg_e --> ala_B_e --> ala__D_e --> ala__L_e --> alaala_e --> all__D_e --> alltn_e --> amp_e --> anhgm_e --> arab__L_e --> arbt_e --> arbtn_e --> arbtn_fe3_e --> arg__L_e --> ascb__L_e --> asn__L_e --> aso3_e --> asp__L_e --> btn_e --> but_e --> butso3_e --> ca2_e <=> cbi_e --> cbl1_e <=> cd2_e --> cgly_e --> chol_e --> chtbs_e --> cit_e --> cl_e <=> cm_e --> cmp_e --> co2_e <=> cobalt2_e <=> colipa_e --> colipap_e --> cpgn_e --> cpgn_un_e --> crn_e --> crn__D_e --> csn_e --> cu_e --> cu2_e <=> cyan_e --> cynt_e --> cys__D_e --> cys__L_e --> cytd_e --> dad_2_e --> damp_e --> dca_e --> dcmp_e --> dcyt_e --> ddca_e --> dgmp_e --> dgsn_e --> dha_e --> dimp_e --> din_e --> dms_e --> dmso_e --> dopa_e --> doxrbcn_e --> dtmp_e --> dump_e --> duri_e --> eca4colipa_e --> enlipa_e --> enter_e --> etha_e --> ethso3_e --> etoh_e --> f6p_e --> fald_e --> fe2_e <=> fe3_e <=> fe3dcit_e --> fe3dhbzs_e --> fe3hox_e --> fe3hox_un_e --> fecrm_e --> fecrm_un_e --> feenter_e --> feoxam_e --> feoxam_un_e --> for_e --> fru_e --> frulys_e --> fruur_e --> fuc__L_e --> fum_e --> fusa_e --> g1p_e --> g3pc_e --> g3pe_e --> g3pg_e --> g3pi_e --> g3ps_e --> g6p_e --> gal_e --> gal_bD_e --> gal1p_e --> galct__D_e --> galctn__D_e --> galctn__L_e --> galt_e --> galur_e --> gam_e --> gam6p_e --> gbbtn_e --> gdp_e --> glc__D_e <=> glcn_e --> glcr_e --> glcur_e --> glcur1p_e --> gln__L_e --> glu__L_e --> gly_e --> glyald_e --> glyb_e --> glyc_e --> glyc__R_e --> glyc2p_e --> glyc3p_e --> glyclt_e --> gmp_e --> gsn_e --> gthox_e --> gthrd_e --> gtp_e --> gua_e --> h_e <=> h2_e --> h2o_e <=> h2o2_e --> h2s_e --> hacolipa_e --> halipa_e --> hdca_e --> hdcea_e --> hg2_e --> his__L_e --> hom__L_e --> hxa_e --> hxan_e --> idon__L_e --> ile__L_e --> imp_e --> indole_e --> inost_e --> ins_e --> isetac_e --> k_e <=> kdo2lipid4_e --> lac__D_e --> lac__L_e --> lcts_e --> leu__L_e --> lipa_e --> lipa_cold_e --> lipoate_e --> lys__L_e --> lyx__L_e --> mal__D_e --> mal__L_e --> malt_e --> malthx_e --> maltpt_e --> malttr_e --> maltttr_e --> man_e --> man6p_e --> manglyc_e --> melib_e --> meoh_e --> met__D_e --> met__L_e --> metsox_R__L_e --> metsox_S__L_e --> mg2_e <=> mincyc_e --> minohp_e --> mmet_e --> mn2_e <=> mnl_e --> mobd_e <=> mso3_e --> n2o_e --> na1_e <=> nac_e --> nh4_e <=> ni2_e <=> nmn_e --> no_e --> no2_e --> no3_e --> novbcn_e --> o16a4colipa_e --> o2_e <=> o2s_e --> ocdca_e --> ocdcea_e --> octa_e --> orn_e --> orot_e --> pacald_e --> peamn_e --> phe__L_e --> pheme_e --> pi_e <=> pnto__R_e --> ppa_e --> ppal_e --> pppn_e --> ppt_e --> pro__L_e --> progly_e --> psclys_e --> pser__L_e --> ptrc_e --> pydam_e --> pydx_e --> pydxn_e --> pyr_e --> quin_e --> r5p_e --> rfamp_e --> rib__D_e --> rmn_e --> sbt__D_e --> sel_e <=> ser__D_e --> ser__L_e --> skm_e --> slnt_e <=> so2_e --> so3_e --> so4_e <=> spmd_e --> succ_e --> sucr_e --> sulfac_e --> tartr__D_e --> tartr__L_e --> taur_e --> tcynt_e --> thm_e --> thr__L_e --> thrp_e --> thym_e --> thymd_e --> tma_e --> tmao_e --> tre_e --> trp__L_e --> tsul_e --> ttdca_e --> ttdcea_e --> ttrcyc_e --> tungs_e <=> tym_e --> tyr__L_e --> tyrp_e --> uacgam_e --> udpacgal_e --> udpg_e --> udpgal_e --> udpglcur_e --> ump_e --> ura_e --> urea_e --> uri_e --> val__L_e --> xan_e --> xmp_e --> xtsn_e --> xyl__D_e --> xylu__L_e --> zn2_e <=> 12dgr120_p --> 12dgr120_c 12dgr140_p --> 12dgr140_c 12dgr141_p --> 12dgr141_c 12dgr160_p --> 12dgr160_c 12dgr161_p --> 12dgr161_c 12dgr180_p --> 12dgr180_c 12dgr181_p --> 12dgr181_c 12ppd__R_e <=> 12ppd__R_p 12ppd__R_p <=> 12ppd__R_c 12ppd__S_e <=> 12ppd__S_p 12ppd__S_p <=> 12ppd__S_c 14glucan_p + atp_c + h2o_c --> 14glucan_c + pi_c + h_c + adp_c 14glucan_e --> 14glucan_p 23camp_e <=> 23camp_p 23ccmp_e <=> 23ccmp_p 23cgmp_e <=> 23cgmp_p 23cump_e <=> 23cump_p 23dappa_p + h_p --> 23dappa_c + h_c 23dappa_e <=> 23dappa_p 23cump_p + h2o_p --> h_p + 3ump_p 23ccmp_p + h2o_p --> 3cmp_p + h_p h2o_p + 23camp_p --> h_p + 3amp_p 23cgmp_p + h2o_p --> h_p + 3gmp_p 26dap__M_e <=> 26dap__M_p 2ddecg3p_p --> 2ddecg3p_c 2tdecg3p_p --> 2tdecg3p_c 2tdec7eg3p_p --> 2tdec7eg3p_c 2hdecg3p_p --> 2hdecg3p_c 2hdec9eg3p_p --> 2hdec9eg3p_c 2odecg3p_p --> 2odecg3p_c 2odec11eg3p_p --> 2odec11eg3p_c 2agpe120_p --> 2agpe120_c 2agpe140_p --> 2agpe140_c 2agpe141_p --> 2agpe141_c 2agpe160_p --> 2agpe160_c 2agpe161_p --> 2agpe161_c 2agpe180_p --> 2agpe180_c 2agpe181_p --> 2agpe181_c ddca_c + 2agpe120_c + atp_c --> ppi_c + pe120_c + amp_c 2agpe140_c + ttdca_c + atp_c --> pe140_c + ppi_c + amp_c ttdcea_c + 2agpe141_c + atp_c --> pe141_c + ppi_c + amp_c hdca_c + 2agpe160_c + atp_c --> pe160_c + ppi_c + amp_c hdcea_c + 2agpe161_c + atp_c --> ppi_c + pe161_c + amp_c 2agpe180_c + ocdca_c + atp_c --> ppi_c + pe180_c + amp_c 2agpe181_c + ocdcea_c + atp_c --> ppi_c + pe181_c + amp_c 2agpg120_p --> 2agpg120_c 2agpg140_p --> 2agpg140_c 2agpg141_p --> 2agpg141_c 2agpg160_p --> 2agpg160_c 2agpg161_p --> 2agpg161_c 2agpg180_p --> 2agpg180_c 2agpg181_p --> 2agpg181_c ddca_c + 2agpg120_c + atp_c --> pg120_c + ppi_c + amp_c 2agpg140_c + ttdca_c + atp_c --> ppi_c + amp_c + pg140_c ttdcea_c + 2agpg141_c + atp_c --> ppi_c + pg141_c + amp_c hdca_c + 2agpg160_c + atp_c --> pg160_c + ppi_c + amp_c 2agpg161_c + hdcea_c + atp_c --> pg161_c + ppi_c + amp_c ocdca_c + 2agpg180_c + atp_c --> pg180_c + ppi_c + amp_c 2agpg181_c + ocdcea_c + atp_c --> ppi_c + pg181_c + amp_c 2dhguln_c + nadh_c + h_c --> glcn_c + nad_c 2dhguln_c + nadph_c + h_c --> glcn_c + nadp_c 2dhguln_c + nadh_c + h_c --> nad_c + idon__L_c 2dhguln_c + nadph_c + h_c --> nadp_c + idon__L_c 2mahmp_c + h2o_c --> pi_c + 4ampm_c + h_c 34dhpac_e <=> 34dhpac_p 3amac_c + h2o_c + h_c --> nh4_c + msa_c 3amp_e <=> 3amp_p 3cmp_e <=> 3cmp_p 3gmp_e <=> 3gmp_p 3hdecACP_c --> h2o_c + tdec2eACP_c 3hddecACP_c --> h2o_c + tddec2eACP_c 3hcddec5eACP_c --> t3c5ddeceACP_c + h2o_c 3hmrsACP_c --> h2o_c + tmrs2eACP_c 3hcmrs7eACP_c --> t3c7mrseACP_c + h2o_c 3hpalmACP_c --> h2o_c + tpalm2eACP_c 3hcpalm9eACP_c --> h2o_c + t3c9palmeACP_c 3hoctaACP_c --> toctd2eACP_c + h2o_c 3hcvac11eACP_c --> t3c11vaceACP_c + h2o_c 3haACP_c --> but2eACP_c + h2o_c 3hhexACP_c --> thex2eACP_c + h2o_c 3hoctACP_c --> toct2eACP_c + h2o_c 3hcinnm_c + h_c + nadh_c + o2_c --> dhcinnm_c + nad_c + h2o_c 3hpppn_c + nadh_c + h_c + o2_c --> nad_c + dhpppn_c + h2o_c 3hpp_e <=> 3hpp_p 3hpp_c + h_c --> 3hpp_p + h_p 3dhguln_c + atp_c --> adp_c + 3dhgulnp_c + h_c 3ump_p + h2o_p --> pi_p + uri_p 3cmp_p + h2o_p --> cytd_p + pi_p h2o_p + 3amp_p --> pi_p + adn_p h2o_p + 3gmp_p --> gsn_p + pi_p 3odecACP_c + nadph_c + h_c <=> nadp_c + 3hdecACP_c 3oddecACP_c + h_c + nadph_c <=> nadp_c + 3hddecACP_c nadph_c + 3ocddec5eACP_c + h_c --> nadp_c + 3hcddec5eACP_c nadph_c + 3omrsACP_c + h_c <=> 3hmrsACP_c + nadp_c 3ocmrs7eACP_c + nadph_c + h_c --> 3hcmrs7eACP_c + nadp_c 3opalmACP_c + nadph_c + h_c <=> nadp_c + 3hpalmACP_c nadph_c + h_c + 3ocpalm9eACP_c --> nadp_c + 3hcpalm9eACP_c nadph_c + 3ooctdACP_c + h_c <=> nadp_c + 3hoctaACP_c nadph_c + 3ocvac11eACP_c + h_c --> 3hcvac11eACP_c + nadp_c actACP_c + nadph_c + h_c <=> nadp_c + 3haACP_c nadph_c + h_c + 3ohexACP_c <=> nadp_c + 3hhexACP_c nadph_c + 3ooctACP_c + h_c <=> nadp_c + 3hoctACP_c ocACP_c + h_c + malACP_c --> co2_c + 3odecACP_c + ACP_c h_c + dcaACP_c + malACP_c --> co2_c + 3oddecACP_c + ACP_c h_c + malACP_c + cdec3eACP_c --> co2_c + ACP_c + 3ocddec5eACP_c ddcaACP_c + h_c + malACP_c --> 3omrsACP_c + co2_c + ACP_c cddec5eACP_c + h_c + malACP_c --> co2_c + 3ocmrs7eACP_c + ACP_c malACP_c + myrsACP_c + h_c --> co2_c + 3opalmACP_c + ACP_c tdeACP_c + h_c + malACP_c --> co2_c + ACP_c + 3ocpalm9eACP_c palmACP_c + h_c + malACP_c --> co2_c + 3ooctdACP_c + ACP_c h_c + hdeACP_c + malACP_c --> co2_c + ACP_c + 3ocvac11eACP_c h_c + butACP_c + malACP_c --> 3ohexACP_c + co2_c + ACP_c h_c + hexACP_c + malACP_c --> co2_c + ACP_c + 3ooctACP_c coa_c + oxadpcoa_c --> accoa_c + succoa_c LalaDgluMdap_p + h2o_c + atp_c --> h_c + pi_c + LalaDgluMdap_c + adp_c LalaDgluMdap_e <=> LalaDgluMdap_p 3ump_e <=> 3ump_p dopa_p + h2o_p + o2_p --> nh4_p + 34dhpac_p + h2o2_p 4hoxpacd_e <=> 4hoxpacd_p h2o_c + phthr_c --> 4hthr_c + pi_c h2o_c + LalaDgluMdapDala_c --> ala__D_c + LalaDgluMdap_c LalaDgluMdapDala_p + h2o_p --> LalaDgluMdap_p + ala__D_p LalaDgluMdapDala_p + atp_c + h2o_c --> LalaDgluMdapDala_c + pi_c + h_c + adp_c LalaDgluMdapDala_e <=> LalaDgluMdapDala_p nadph_c + 5dglcn_c + h_c <=> glcn_c + nadp_c 5dglcn_p + h_p <=> 5dglcn_c + h_c 5dglcn_e <=> 5dglcn_p dad_5_c + h2o_c --> 5drib_c + ade_c 5mtr_e <=> 5mtr_p 5mtr_c + h_c --> h_p + 5mtr_p ru5p__D_c <=> ara5p_c ACP_c + ttdca_c + atp_c --> ppi_c + myrsACP_c + amp_c ttdcea_c + ACP_c + atp_c --> tdeACP_c + ppi_c + amp_c hdca_c + ACP_c + atp_c --> palmACP_c + ppi_c + amp_c hdcea_c + ACP_c + atp_c --> ppi_c + hdeACP_c + amp_c ACP_c + ocdcea_c + atp_c --> ppi_c + octeACP_c + amp_c ACP_c + ocdca_c + atp_c --> ocdcaACP_c + ppi_c + amp_c ddca_c + ACP_c + atp_c --> ddcaACP_c + ppi_c + amp_c ACP_c + dca_c + atp_c --> ppi_c + dcaACP_c + amp_c ACP_c + atp_c + octa_c --> ocACP_c + ppi_c + amp_c aact_c + o2_c + h2o_c --> mthgxl_c + h2o2_c + nh4_c unagamu_c + dtdp4aaddg_c --> unagamuf_c + dtdp_c + h_c 14glucan_c --> malthx_c 14glucan_p --> malthx_p arbt6p_c + h2o_c --> g6p_c + hqn_c 4abut_c + akg_c --> glu__L_c + sucsal_c nad_c + 4abutn_c + h2o_c --> 4abut_c + 2.0 h_c + nadh_c 4abut_p + h_p --> 4abut_c + h_c 4abut_e <=> 4abut_p accoa_c + acac_c --> ac_c + aacoa_c 2.0 accoa_c <=> coa_c + aacoa_c accoa_c + btcoa_c <=> coa_c + 3ohcoa_c hxcoa_c + accoa_c <=> coa_c + 3oocoa_c accoa_c + occoa_c <=> 3odcoa_c + coa_c dcacoa_c + accoa_c <=> coa_c + 3oddcoa_c accoa_c + ddcacoa_c <=> coa_c + 3otdcoa_c tdcoa_c + accoa_c <=> 3ohdcoa_c + coa_c 3oodcoa_c + coa_c <=> accoa_c + pmtcoa_c h_p + acac_p <=> acac_c + h_c acac_e <=> acac_p acald_c + coa_c + nad_c <=> h_c + nadh_c + accoa_c acald_e <=> acald_p acald_p <=> acald_c anth_c + accoa_c --> coa_c + acanth_c adocbip_c + gtp_c + h_c --> ppi_c + agdpcbi_c hco3_c + accoa_c + atp_c --> malcoa_c + h_c + pi_c + adp_c ppa_c + coa_c + atp_c --> ppcoa_c + pi_c + adp_c acgal1p_p + h2o_p --> acgal_p + pi_p acgal1p_e <=> acgal1p_p acgal_e <=> acgal_p acgam1p_p + h2o_p --> pi_p + acgam_p acgam1p_e <=> acgam1p_p atp_c + acgam_c --> acgam6p_c + adp_c + h_c udcpp_c + uacgam_c --> ump_c + unaga_c pep_c + acgam_p --> acgam6p_c + pyr_c acgam_e <=> acgam_p acglu_c + atp_c --> acg5p_c + adp_c glu__L_c + accoa_c --> coa_c + acglu_c + h_c 2obut_c + pyr_c + h_c --> 2ahbut_c + co2_c ac_c + atp_c <=> actp_c + adp_c 2.0 pyr_c + h_c --> co2_c + alac__S_c h2o_c + acmum6p_c --> acgam6p_c + lac__D_c uacmamu_c + unaga_c --> unagamu_c + udp_c + h_c pep_c + acmana_p --> acmanap_c + pyr_c acmana_e <=> acmana_p pep_c + acmum_p --> pyr_c + acmum6p_c acmum_e --> acmum_p h_p + acnam_p --> acnam_c + h_c acnam_e <=> acnam_p acnam_c --> acmana_c + pyr_c fad_c + btcoa_c <=> b2coa_c + fadh2_c hxcoa_c + fad_c <=> hx2coa_c + fadh2_c fad_c + occoa_c <=> fadh2_c + oc2coa_c dcacoa_c + fad_c <=> dc2coa_c + fadh2_c fad_c + ddcacoa_c <=> fadh2_c + dd2coa_c tdcoa_c + fad_c <=> fadh2_c + td2coa_c fad_c + pmtcoa_c <=> hdd2coa_c + fadh2_c stcoa_c + fad_c <=> fadh2_c + od2coa_c ACP_c + accoa_c <=> coa_c + acACP_c acorn_c + h2o_c --> orn_c + ac_c acolipa_p + atp_c + h2o_c --> acolipa_e + h_c + pi_c + adp_c acon_T_c <=> acon_C_c acon_T_c + amet_c --> ahcys_c + aconm_c cit_c <=> acon_C_c + h2o_c acon_C_c + h2o_c <=> icit_c akg_c + acorn_c <=> acg5sa_c + glu__L_c pi_c + ddcaACP_c + h_c --> ACP_c + ddcap_c myrsACP_c + pi_c + h_c --> ACP_c + ttdcap_c pi_c + tdeACP_c + h_c --> ACP_c + ttdceap_c palmACP_c + pi_c + h_c --> ACP_c + hdcap_c pi_c + h_c + hdeACP_c --> ACP_c + hdceap_c pi_c + ocdcaACP_c + h_c --> ACP_c + ocdcap_c pi_c + octeACP_c + h_c --> ocdceap_c + ACP_c apoACP_c + coa_c --> pap_c + ACP_c + h_c coa_c + ac_c + atp_c --> ppi_c + accoa_c + amp_c acser_e <=> acser_p acser_c --> acser_p h_p + ac_p <=> ac_c + h_c ac_p + na1_p --> ac_c + na1_c ac_e <=> ac_p adn_c + h_c + h2o_c --> ins_c + nh4_c 4adcho_c --> pyr_c + 4abz_c + h_c chor_c + gln__L_c --> 4adcho_c + glu__L_c ade_c + h2o_c + h_c --> hxan_c + nh4_c h_p + ade_p <=> ade_c + h_c ade_e <=> ade_p amp_c + atp_c <=> 2.0 adp_c amp_c + gtp_c <=> gdp_c + adp_c itp_c + amp_c <=> idp_c + adp_c amet_c + h_c --> ametam_c + co2_c atp_c --> ppi_c + camp_c adn_c + atp_c --> amp_c + adp_c + h_c adn_c + h2o_c --> rib__D_c + ade_c h_p + adn_p --> adn_c + h_c h_p + adn_p <=> adn_c + h_c adn_e <=> adn_p adocbi_c + atp_c --> adp_c + adocbip_c + h_c rdmbzi_c + agdpcbi_c --> adocbl_c + gmp_c + h_c adocbl_p + atp_c + h2o_c --> h_c + adocbl_c + pi_c + adp_c adocbl_e + h_p --> adocbl_p + h_c adprib_c + h2o_c --> amp_c + 2.0 h_c + r5p_c ade_c + prpp_c --> ppi_c + amp_c aps_c + atp_c --> paps_c + adp_c + h_c dcamp_c <=> fum_c + amp_c 25aics_c <=> fum_c + aicar_c imp_c + asp__L_c + gtp_c --> gdp_c + 2.0 h_c + pi_c + dcamp_c acgam6p_c + h2o_c --> gam6p_c + ac_c anhgm3p_c + h2o_c --> anhgm_c + LalaDgluMdap_c anhgm3p_p + h2o_p --> LalaDgluMdap_p + anhgm_p anhgm3p_c + h2o_c --> anhm3p_c + acgam_c h_p + anhgm3p_p --> anhgm3p_c + h_c h2o_c + anhgm4p_c --> anhgm_c + LalaDgluMdapDala_c h2o_p + anhgm4p_p --> LalaDgluMdapDala_p + anhgm_p h2o_c + anhgm4p_c --> anhgm3p_c + ala__D_c h2o_p + anhgm4p_p --> anhgm3p_p + ala__D_p anhgm4p_c + h2o_c --> anhm4p_c + acgam_c h_p + anhgm4p_p --> anhgm4p_c + h_c anhgm_c + h2o_c --> anhm_c + acgam_c adphep_DD_c --> adphep_LD_c agm_c + h2o_c --> urea_c + ptrc_c h_p + anhgm_p --> anhgm_c + h_c agm_e <=> agm_p ddcaACP_c + 1ddecg3p_c --> ACP_c + pa120_c myrsACP_c + 1tdecg3p_c --> ACP_c + pa140_c 1tdec7eg3p_c + tdeACP_c --> ACP_c + pa141_c palmACP_c + 1hdecg3p_c --> pa160_c + ACP_c hdeACP_c + 1hdec9eg3p_c --> ACP_c + pa161_c ocdcaACP_c + 1odecg3p_c --> pa180_c + ACP_c 1odec11eg3p_c + octeACP_c --> pa181_c + ACP_c acg5sa_c + pi_c + nadp_c <=> nadph_c + acg5p_c + h_c h_e + ag_c --> ag_e + h_c ahcys_c + h2o_c --> rhcys_c + ade_c 10fthf_c + aicar_c <=> fprica_c + thf_c air_c + hco3_c + atp_c --> h_c + pi_c + 5caiz_c + adp_c 5aizc_c <=> 5caiz_c akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c h_p + akg_p <=> akg_c + h_c akg_e <=> akg_p alaala_c + h2o_c --> 2.0 ala__D_c alaala_p + atp_c + h2o_c --> h_c + pi_c + alaala_c + adp_c 2.0 ala__D_c + atp_c <=> h_c + pi_c + alaala_c + adp_c alaala_e <=> alaala_p LalaDglu_c <=> LalaLglu_c ala__L_c <=> ala__D_c pydx5p_c + ala__D_c --> pyr_c + pyam5p_c ala__L_c + akg_c <=> pyr_c + glu__L_c ala__L_c + pydx5p_c --> pyr_c + pyam5p_c trnaala_c + ala__L_c + atp_c --> ppi_c + amp_c + alatrna_c ala__L_p + atp_c + h2o_c --> h_c + ala__L_c + pi_c + adp_c ala__L_p + h_p --> ala__L_c + h_c ala__L_p + h_p <=> ala__L_c + h_c ala__L_p + na1_p --> ala__L_c + na1_c ala__L_e <=> ala__L_p nadh_c + glyald_c + h_c <=> nad_c + glyc_c etoh_c + nad_c <=> nadh_c + acald_c + h_c nad_c + pacald_c + h2o_c <=> pac_c + 2.0 h_c + nadh_c acald_c + nad_c + h2o_c --> nadh_c + 2.0 h_c + ac_c acald_c + nadp_c + h2o_c --> nadph_c + 2.0 h_c + ac_c nadp_c + ppal_c + h2o_c --> 2.0 h_c + ppa_c + nadph_c nad_c + btal_c + h2o_c --> but_c + 2.0 h_c + nadh_c all__D_c + atp_c --> adp_c + all6p_c + h_c all6p_c <=> allul6p_c alltt_c + 2.0 h_c + 2.0 h2o_c --> co2_c + urdglyc_c + 2.0 nh4_c alltn_c + h2o_c --> alltt_c + h_c h_p + alltn_p <=> alltn_c + h_c alltn_e <=> alltn_p allul6p_c <=> f6p_c all__D_p + atp_c + h2o_c --> all__D_c + h_c + pi_c + adp_c all__D_e <=> all__D_p pe160_p + alpp_p --> lpp_p + 2agpe160_p alpp_p + pg160_p --> lpp_p + 2agpg160_p mthgxl_c + nadph_c + h_c --> acetol_c + nadp_c h_c + acetol_c + nadh_c --> nad_c + 12ppd__R_c altrn_c --> 2ddglcn_c + h2o_c anhm3p_c + h2o_c --> LalaDgluMdap_c + anhm_c anhm4p_c + h2o_c --> anhm_c + LalaDgluMdapDala_c anhm4p_c + h2o_c --> anhm3p_c + ala__D_c malttr_c + malt_c --> glc__D_c + maltttr_c malt_c + maltttr_c --> glc__D_c + maltpt_c malt_c + maltpt_c --> glc__D_c + malthx_c malt_c + malthx_c --> glc__D_c + malthp_c acmanap_c <=> acgam6p_c acmana_c + atp_c --> acmanap_c + adp_c + h_c 8aonn_c + amet_c <=> amob_c + dann_c 2dmmql8_c + amet_c --> ahcys_c + mql8_c + h_c air_c + nad_c + h2o_c --> nadh_c + 2.0 for_c + 3.0 h_c + 4ampm_c amp_c + h2o_c --> ade_c + r5p_c h2o_c + cgly_c --> gly_c + cys__L_c h2o_c + progly_c --> pro__L_c + gly_c amp_e <=> amp_p anhgm_e <=> anhgm_p h2o_c + anhm_c + atp_c --> adp_c + h_c + acmum6p_c anth_c + prpp_c --> pran_c + ppi_c chor_c + gln__L_c --> anth_c + h_c + pyr_c + glu__L_c 2aobut_c + h_c --> aact_c + co2_c ala__L_c + pimACP_c --> ACP_c + 8aonn_c + co2_c ap4a_c + h2o_c --> 2.0 h_c + 2.0 adp_c 2.0 atp_c + h_c --> ap4a_c + ppi_c ap5a_c + h2o_c --> adp_c + atp_c + 2.0 h_c ametam_c + 15dap_c --> 5mta_c + na15dap_c + h_c glyc3p_c + ddcap_c --> pi_c + 1ddecg3p_c + h_c glyc3p_c + ttdcap_c --> pi_c + 1tdecg3p_c + h_c glyc3p_c + ttdceap_c --> 1tdec7eg3p_c + pi_c + h_c glyc3p_c + hdcap_c --> 1hdecg3p_c + pi_c + h_c glyc3p_c + hdceap_c --> h_c + 1hdec9eg3p_c + pi_c glyc3p_c + ocdcap_c --> pi_c + 1odecg3p_c + h_c ocdceap_c + glyc3p_c --> 1odec11eg3p_c + pi_c + h_c h2o_c + ddcap_c --> pi_c + ddca_c + 2.0 h_c h2o_c + ttdcap_c --> pi_c + ttdca_c + 2.0 h_c ttdceap_c + h2o_c --> ttdcea_c + pi_c + 2.0 h_c hdcap_c + h2o_c --> pi_c + 2.0 h_c + hdca_c h2o_c + hdceap_c --> pi_c + 2.0 h_c + hdcea_c h2o_c + ocdcap_c --> ocdca_c + pi_c + 2.0 h_c ocdceap_c + h2o_c --> pi_c + ocdcea_c + 2.0 h_c h_c + nadh_c + aact_c <=> nad_c + appl_c nadph_c + 5apru_c + h_c --> 5aprbu_c + nadp_c arab__L_c <=> rbl__L_c 2.0 arbtn_fe3_c + fadh2_c --> 2.0 arbtn_c + 2.0 h_c + fad_c + 2.0 fe2_c 2.0 arbtn_fe3_c + fmnh2_c --> 2.0 arbtn_c + 2.0 h_c + 2.0 fe2_c + fmn_c 2.0 arbtn_fe3_c + rbflvrd_c --> 2.0 arbtn_c + 2.0 h_c + 2.0 fe2_c + ribflv_c arbtn_fe3_p + atp_c + h2o_c --> arbtn_fe3_c + h_c + pi_c + adp_c arbtn_e + fe3_e --> arbtn_fe3_e arbtn_p + h_p --> arbtn_e + h_c h_p + arbtn_fe3_e --> arbtn_fe3_p + h_c arbtn_c + h_p --> arbtn_p + h_c pep_c + arbt_p --> pyr_c + arbt6p_c arbt_e --> arbt_p arab__L_p + atp_c + h2o_c --> h_c + pi_c + arab__L_c + adp_c arab__L_p + h_p <=> arab__L_c + h_c arab__L_c + h_p --> arab__L_p + h_c arab__L_e <=> arab__L_p agm_c + arg__L_p <=> arg__L_c + agm_p arg__L_c + h_c --> agm_c + co2_c h_p + arg__L_p --> agm_p + co2_p orn_c + arg__L_p <=> arg__L_c + orn_p argsuc_c <=> arg__L_c + fum_c asp__L_c + atp_c + citr__L_c --> argsuc_c + ppi_c + h_c + amp_c arg__L_c + trnaarg_c + atp_c --> ppi_c + argtrna_c + amp_c arg__L_p + atp_c + h2o_c --> arg__L_c + pi_c + h_c + adp_c arg__L_c + h_p --> h_c + arg__L_p arg__L_e <=> arg__L_p pi_c + aspsa_c + nadp_c <=> nadph_c + h_c + 4pasp_c h2o_c + ascb6p_c --> h_c + 3dhgulnp_c ascb__L_p + pep_c --> pyr_c + ascb6p_c ascb__L_e <=> ascb__L_p asn__L_c + h2o_c --> nh4_c + asp__L_c asn__L_p + h2o_p --> nh4_p + asp__L_p atp_c + asp__L_c + h2o_c + gln__L_c --> asn__L_c + h_c + ppi_c + glu__L_c + amp_c asp__L_c + nh4_c + atp_c --> asn__L_c + ppi_c + h_c + amp_c asn__L_c + trnaasn_c + atp_c --> ppi_c + asntrna_c + amp_c asn__L_p + atp_c + h2o_c --> asn__L_c + h_c + adp_c + pi_c h_p + asn__L_p <=> asn__L_c + h_c asn__L_e <=> asn__L_p aso3_c + atp_c + h2o_c --> h_c + aso3_p + pi_c + adp_c aso3_e <=> aso3_p asp__L_c + h_c --> co2_c + ala_B_c cbp_c + asp__L_c --> pi_c + cbasp_c + h_c atp_c + asp__L_c <=> 4pasp_c + adp_c q8_c + asp__L_c --> iasp_c + h_c + q8h2_c mqn8_c + asp__L_c --> mql8_c + iasp_c + h_c fum_c + asp__L_c --> iasp_c + succ_c + h_c o2_c + asp__L_c --> h2o2_c + iasp_c + h_c asp__L_c --> nh4_c + fum_c akg_c + asp__L_c <=> oaa_c + glu__L_c asp__L_c + trnaasp_c + atp_c --> asptrna_c + ppi_c + amp_c asp__L_p + atp_c + h2o_c --> asp__L_c + h_c + pi_c + adp_c 2.0 h_p + asp__L_p --> asp__L_c + 2.0 h_c 3.0 h_p + asp__L_p --> asp__L_c + 3.0 h_c h_p + asp__L_p --> asp__L_c + h_c h_p + asp__L_p <=> asp__L_c + h_c asp__L_e <=> asp__L_p 2.0 gthrd_c + aso4_c --> aso3_c + gthox_c + h2o_c arg__L_c + succoa_c --> sucarg_c + coa_c + h_c nadp_c + athr__L_c <=> nadph_c + 2aobut_c + h_c h2o_c + atp_c + h_c --> itp_c + nh4_c h2o_c + atp_c --> pi_c + adp_c + h_c prpp_c + atp_c --> ppi_c + prbatp_c pi_c + 4.0 h_p + adp_c <=> 3.0 h_c + h2o_c + atp_c ala_B_p + h_p --> ala_B_c + h_c ala_B_e <=> ala_B_p betald_c + nad_c + h2o_c --> glyb_c + 2.0 h_c + nadh_c nadp_c + betald_c + h2o_c --> nadph_c + glyb_c + 2.0 h_c mptamp_c + moco_c --> amp_c + cu2_c + bmoco_c bmoco_c + gtp_c + h_c --> ppi_c + bmoco1gdp_c gtp_c + bmoco1gdp_c + h_c --> bmocogdp_c + ppi_c pap_c + h2o_c --> pi_c + amp_c h_c + nadh_c + btnso_c --> btn_c + nad_c + h2o_c nadph_c + h_c + btnso_c --> btn_c + h2o_c + nadp_c h_p + btn_p --> btn_c + h_c btn_e <=> btn_p 2fe2s_c + dtbt_c + amet_c --> dad_5_c + 2fe1s_c + met__L_c + h_c + btn_c but_c + accoa_c --> ac_c + btcoa_c butso3_p + atp_c + h2o_c --> h_c + butso3_c + adp_c + pi_c butso3_e <=> butso3_p but_p + h_p <=> but_c + h_c but_e <=> but_p bwco_c + gtp_c + h_c --> ppi_c + bwco1gdp_c bwco1gdp_c + gtp_c + h_c --> bwcogdp_c + ppi_c mptamp_c + wco_c --> cu2_c + bwco_c + amp_c h_p + ca2_c --> ca2_p + h_c ca2_e <=> ca2_p 15dap_c + lys__L_p + h_p --> lys__L_c + h_c + 15dap_p 2.0 h2o2_c --> o2_c + 2.0 h2o_c ca2_c + na1_p <=> ca2_p + na1_c cbi_c + atp_c + h_c <=> pppi_c + adocbi_c cbi_e + h_p --> cbi_p + h_c cbi_p + atp_c + h2o_c --> cbi_c + h_c + pi_c + adp_c cbl1_p + atp_c + h2o_c --> cbl1_c + h_c + pi_c + adp_c h_p + cbl1_e --> cbl1_p + h_c cbl1_c + atp_c + h_c <=> pppi_c + adocbl_c cbm_c + 2.0 h_c --> co2_c + nh4_c co2_c + nh4_c + atp_c <=> 2.0 h_c + cbp_c + adp_c hco3_c + h2o_c + 2.0 atp_c + gln__L_c --> 2.0 h_c + cbp_c + pi_c + glu__L_c + 2.0 adp_c cdg_c + nh4_c + atp_c --> h_c + h2o_c + preq0_c + pi_c + adp_c cd2_c + atp_c + h2o_c --> cd2_p + h_c + pi_c + adp_c h_p + cd2_c --> cd2_p + h_c cd2_e <=> cd2_p cd2_p --> cd2_c h2o_c + cdpdddecg_c --> cmp_c + pa120_c + 2.0 h_c cdpdtdecg_c + h2o_c --> pa140_c + cmp_c + 2.0 h_c h2o_c + cdpdtdec7eg_c --> 2.0 h_c + pa141_c + cmp_c h2o_c + cdpdhdecg_c --> pa160_c + cmp_c + 2.0 h_c h2o_c + cdpdhdec9eg_c --> 2.0 h_c + cmp_c + pa161_c cdpdodecg_c + h2o_c --> pa180_c + cmp_c + 2.0 h_c h2o_c + cdpdodec11eg_c --> pa181_c + cmp_c + 2.0 h_c preq0_c + 2.0 nadph_c + 3.0 h_c --> 2.0 nadp_c + preq1_c cph4_c + h_c --> cdg_c + nh4_c 4c2me_c + atp_c --> 2p4c2me_c + adp_c + h_c 2.0 amet_c + pe161_c --> 2.0 ahcys_c + 2.0 h_c + cpe160_c 2.0 amet_c + pg161_c --> cpg160_c + 2.0 ahcys_c + 2.0 h_c pe181_c + 2.0 amet_c --> 2.0 ahcys_c + 2.0 h_c + cpe180_c pg181_c + 2.0 amet_c --> 2.0 ahcys_c + cpg180_c + 2.0 h_c h2o_c + cgly_p + atp_c --> h_c + pi_c + adp_c + cgly_c cgly_e <=> cgly_p chol_p + atp_c + h2o_c --> chol_c + h_c + pi_c + adp_c h_p + chol_p --> chol_c + h_c chol_e <=> chol_p nad_c + chol_c --> nadh_c + betald_c + h_c chor_c --> pphn_c 3psme_c --> pi_c + chor_c chor_c --> pyr_c + 4hbz_c pep_c + chtbs_p --> pyr_c + chtbs6p_c chtbs_e <=> chtbs_p cinnm_c + h_c + nadh_c + o2_c --> cenchddd_c + nad_c cit_c --> oaa_c + ac_c h_p + cit_c --> cit_p + h_c cit_p + succ_c --> succ_p + cit_c cit_e <=> cit_p lipa_cold_p + atp_c + h2o_c --> lipa_cold_e + h_c + pi_c + adp_c clpn120_p + h2o_p --> pa120_p + pg120_p + h_p h2o_p + clpn140_p --> h_p + pa140_p + pg140_p clpn141_p + h2o_p --> pg141_p + h_p + pa141_p clpn160_p + h2o_p --> pa160_p + h_p + pg160_p clpn161_p + h2o_p --> pg161_p + h_p + pa161_p clpn180_p + h2o_p --> pa180_p + h_p + pg180_p clpn181_p + h2o_p --> h_p + pa181_p + pg181_p 2.0 pg120_p <=> clpn120_p + glyc_p 2.0 pg140_p <=> glyc_p + clpn140_p 2.0 pg141_p <=> clpn141_p + glyc_p 2.0 pg160_p <=> clpn160_p + glyc_p 2.0 pg161_p <=> glyc_p + clpn161_p 2.0 pg180_p <=> clpn180_p + glyc_p 2.0 pg181_p <=> clpn181_p + glyc_p 2.0 cl_p + h_c --> 2.0 cl_c + h_p cl_e <=> cl_p cmp_c + h2o_c --> csn_c + r5p_c cmp_e <=> cmp_p cm_e <=> cm_p cm_p + h_p --> cm_e + h_c co2_e <=> co2_p co2_p <=> co2_c cobalt2_c + atp_c + h2o_c --> cobalt2_p + h_c + pi_c + adp_c h_p + cobalt2_c --> cobalt2_p + h_c cobalt2_e <=> cobalt2_p cobalt2_p --> cobalt2_c colipa_p + udcpdp_p --> colipap_p + udcpp_p colipap_p + atp_c + h2o_c --> pi_c + h_c + colipap_e + adp_c colipa_c + atp_c + h2o_c --> h_c + pi_c + adp_c + colipa_p colipa_p + h2o_c + atp_c --> h_c + pi_c + colipa_e + adp_c 2.0 cpgn_c + fadh2_c --> 2.0 h_c + fad_c + 2.0 fe2_c + 2.0 cpgn_un_c 2.0 cpgn_c + fmnh2_c --> 2.0 h_c + 2.0 fe2_c + fmn_c + 2.0 cpgn_un_c 2.0 cpgn_c + rbflvrd_c --> 2.0 h_c + 2.0 fe2_c + 2.0 cpgn_un_c + ribflv_c cpgn_un_p + h_p --> cpgn_un_e + h_c h_p + cpgn_un_c --> cpgn_un_p + h_c cpgn_p + atp_c + h2o_c --> h_c + pi_c + cpgn_c + adp_c fe3_e + cpgn_un_e --> cpgn_e cpgn_e + h_p --> cpgn_p + h_c ahdt_c + h2o_c --> acald_c + h_c + pppi_c + cph4_c gtp_c + h2o_c --> cpmp_c + ppi_c cpppg3_c + 2.0 h_c + o2_c --> 2.0 co2_c + pppg9_c + 2.0 h2o_c cpppg3_c + 2.0 amet_c --> 2.0 met__L_c + 2.0 co2_c + 2.0 dad_5_c + pppg9_c bbtcoa_c + crn_c <=> gbbtn_c + crncoa_c crn_c + coa_c + atp_c --> crncoa_c + pi_c + adp_c crncoa_c <=> crnDcoa_c ctbtcoa_c + crn_c <=> crncoa_c + ctbt_c crncoa_c <=> ctbtcoa_c + h2o_c crn__D_c + coa_c + atp_c --> crnDcoa_c + pi_c + adp_c crn__D_p + atp_c + h2o_c --> crn__D_c + h_c + pi_c + adp_c h_p + crn__D_p <=> h_c + crn__D_c crn__D_e <=> crn__D_p crn_p + atp_c + h2o_c --> crn_c + h_c + pi_c + adp_c crn_p + h_p <=> crn_c + h_c crn_p + gbbtn_c --> crn_c + gbbtn_p crn_p + crn__D_c --> crn_c + crn__D_p crn_e <=> crn_p oaa_c + accoa_c + h2o_c --> cit_c + h_c + coa_c h_c + csn_c + h2o_c --> nh4_c + ura_c csn_p + h_p --> csn_c + h_c csn_e <=> csn_p ctbt_c + coa_c + atp_c --> ctbtcoa_c + pi_c + adp_c ctbt_p + atp_c + h2o_c --> ctbt_c + h_c + pi_c + adp_c ctbt_p + h_p <=> ctbt_c + h_c tdecoa_c <=> td2coa_c hdcoa_c <=> hdd2coa_c odecoa_c <=> od2coa_c utp_c + atp_c + h2o_c + gln__L_c --> ctp_c + pi_c + glu__L_c + 2.0 h_c + adp_c 4.0 h_p + 4.0 cu_p + o2_p --> 4.0 cu2_p + 2.0 h2o_p cu_c + atp_c + h2o_c --> cu_p + h_c + pi_c + adp_c cu2_c + atp_c + h2o_c --> cu2_p + h_c + pi_c + adp_c cu2_e <=> cu2_p cu2_p --> cu2_c h_e + cu_c --> cu_e + h_c cu_e <=> cu_p tsul_c + cyan_c --> tcynt_c + so3_c + h_c cyan_p + tsul_p --> so3_p + h_p + tcynt_p cyan_e <=> cyan_p cynt_c + hco3_c + 3.0 h_c --> nh4_c + 2.0 co2_c cynt_p + h_p --> cynt_c + h_c cynt_e <=> cynt_p cys__D_c + h2o_c --> pyr_c + nh4_c + h2s_c cys__L_c + h2o_c --> pyr_c + nh4_c + h2s_c h2o_c + atp_c + cys__D_p --> h_c + pi_c + cys__D_c + adp_c cys__D_e <=> cys__D_p acser_c + h2s_c --> ac_c + cys__L_c + h_c 3sala_c + 2.0 h_c --> ala__L_c + so2_c cyst__L_c + h2o_c --> pyr_c + nh4_c + hcys__L_c cys__L_c + trnacys_c + atp_c --> cystrna_c + ppi_c + amp_c cys__L_c + atp_c + h2o_c --> cys__L_p + h_c + pi_c + adp_c cys__L_p + atp_c + h2o_c --> cys__L_c + h_c + pi_c + adp_c cys__L_e <=> cys__L_p cys__L_c --> cys__L_p 2.0 h_c + 0.5 o2_c + mql8_c --> mqn8_c + 2.0 h_p + h2o_c 2.0 h_c + 0.5 o2_c + q8h2_c --> 2.0 h_p + q8_c + h2o_c 4.0 h_c + 0.5 o2_c + q8h2_c --> 4.0 h_p + q8_c + h2o_c h2o_c + cytd_c + h_c --> nh4_c + uri_c cytd_c + h2o_c --> rib__D_c + csn_c gtp_c + cytd_c --> cmp_c + gdp_c + h_c h_p + cytd_p --> cytd_c + h_c h_p + cytd_p <=> cytd_c + h_c cytd_e <=> cytd_p atp_c + cmp_c <=> cdp_c + adp_c dcmp_c + atp_c <=> adp_c + dcdp_c lac__D_p + h_p <=> lac__D_c + h_c lac__D_e <=> lac__D_p ala__D_c + fad_c + h2o_c --> pyr_c + nh4_c + fadh2_c h_c + h2o_c + dad_2_c --> din_c + nh4_c atp_c + damp_c <=> dadp_c + adp_c dad_2_p + h_p --> dad_2_c + h_c dad_2_e <=> dad_2_p 12dgr120_c + atp_c --> pa120_c + adp_c + h_c 12dgr140_c + atp_c --> pa140_c + adp_c + h_c 12dgr141_c + atp_c --> adp_c + pa141_c + h_c 12dgr160_c + atp_c --> adp_c + pa160_c + h_c 12dgr161_c + atp_c --> h_c + adp_c + pa161_c 12dgr180_c + atp_c --> pa180_c + adp_c + h_c 12dgr181_c + atp_c --> pa181_c + adp_c + h_c h_p + ala__D_p --> ala__D_c + h_c ala__D_e <=> ala__D_p damp_e <=> damp_p 23dappa_c + h2o_c --> pyr_c + 2.0 nh4_c h_c + 26dap__M_c --> lys__L_c + co2_c 26dap_LL_c <=> 26dap__M_c h2o_c + 26dap__M_p + atp_c --> adp_c + h_c + pi_c + 26dap__M_c 15dap_e <=> 15dap_p h_c + pa120_c + ctp_c --> ppi_c + cdpdddecg_c pa140_c + h_c + ctp_c --> cdpdtdecg_c + ppi_c h_c + ctp_c + pa141_c --> ppi_c + cdpdtdec7eg_c h_c + pa160_c + ctp_c --> cdpdhdecg_c + ppi_c h_c + pa161_c + ctp_c --> ppi_c + cdpdhdec9eg_c pa180_c + h_c + ctp_c --> cdpdodecg_c + ppi_c pa181_c + ctp_c + h_c --> cdpdodec11eg_c + ppi_c h2o_c + datp_c + h_c --> nh4_c + ditp_c ru5p__D_c --> h_c + db4p_c + for_c dann_c + co2_c + atp_c --> dtbt_c + 3.0 h_c + pi_c + adp_c chtbs6p_c + h2o_c --> acgam6p_c + acgam_c dca_e <=> dca_p dcmp_e <=> dcmp_p dctp_c + h2o_c + h_c --> nh4_c + dutp_c dcyt_c + h2o_c + h_c --> duri_c + nh4_c h_p + dcyt_p --> dcyt_c + h_c dcyt_e <=> dcyt_p ddca_e --> ddca_p 2dh3dgal_c + atp_c --> adp_c + 2dh3dgal6p_c + h_c h_p + 2ddglcn_p <=> 2ddglcn_c + h_c 2ddglcn_e <=> 2ddglcn_p 2ddglcn_c + atp_c --> 2ddg6p_c + adp_c + h_c e4p_c + pep_c + h2o_c --> pi_c + 2dda7p_c 2dh3dgal6p_c <=> pyr_c + g3p_c dgmp_c + atp_c <=> dgdp_c + adp_c dgmp_e <=> dgmp_p h_p + dgsn_p --> dgsn_c + h_c dgsn_e <=> dgsn_p 23dhacoa_c + h2o_c <=> 3hadpcoa_c 23dhmb_c --> 3mob_c + h2o_c 23dhmp_c --> h2o_c + 3mop_c pep_c + dha_c --> dhap_c + pyr_c dha_e <=> dha_p dha_p <=> dha_c nad_c + 23ddhb_c <=> 23dhb_c + nadh_c + h_c 23dhb_c + atp_c + h_c --> 23dhba_c + ppi_c 23dhbzs_c + h2o_c --> 23dhb_c + ser__L_c nad_c + cenchddd_c --> dhcinnm_c + h_c + nadh_c dhcinnm_c + o2_c --> hkntd_c + h_c 23dhdp_c + nadph_c + h_c --> nadp_c + thdp_c pyr_c + aspsa_c --> 23dhdp_c + 2.0 h2o_c + h_c dhf_c + nadph_c + h_c <=> nadp_c + thf_c dhpt_c + glu__L_c + atp_c --> h_c + dhf_c + pi_c + adp_c dhmpt_c + nadph_c + h_c --> nadp_c + thmnp_c octdp_c + dhna_c + h_c --> ppi_c + co2_c + 2dmmql8_c sbzcoa_c + h_c --> h2o_c + 14dhncoa_c 14dhncoa_c + h2o_c --> coa_c + dhna_c + h_c dhnpt_c <=> gcald_c + 6hmhpt_c dhnpt_c <=> dhmpt_c q8_c + dhor__S_c --> orot_c + q8h2_c mqn8_c + dhor__S_c --> orot_c + mql8_c fum_c + dhor__S_c --> orot_c + succ_c h2o_c + dhor__S_c <=> cbasp_c + h_c nad_c + cechddd_c --> nadh_c + h_c + dhpppn_c 25drapp_c + h2o_c + h_c --> 5apru_c + nh4_c 6hmhptpp_c + 4abz_c --> dhpt_c + ppi_c dhptd_c --> mdhdhf_c dhptdn_c + nadph_c + 3.0 h_c --> thptdn_c + nadp_c nadh_c + dhptdn_c + 3.0 h_c --> thptdn_c + nad_c ahdt_c <=> dhmptp_c 2dda7p_c --> pi_c + 3dhq_c 3dhq_c --> 3dhsk_c + h2o_c dimp_e <=> dimp_p din_p + h_p --> h_c + din_c din_e <=> din_p 25dkglcn_c + nadph_c + h_c --> 2dhguln_c + nadp_c h_c + 25dkglcn_c + nadh_c --> nad_c + 5dglcn_c nadph_c + 25dkglcn_c + h_c --> nadp_c + 5dglcn_c dmpp_c + ipdp_c --> grdp_c + ppi_c h2mb4p_c + h_c + nadh_c --> dmpp_c + nad_c + h2o_c 2omhmbl_c + amet_c --> h_c + ahcys_c + q8h2_c dmso_c + mql8_c --> mqn8_c + dms_c + h2o_c mql8_c + dmso_p --> dms_p + mqn8_c + h2o_p 2dmmql8_c + dmso_c --> dms_c + 2dmmq8_c + h2o_c 2dmmql8_c + dmso_p --> dms_p + h2o_p + 2dmmq8_c dmso_e <=> dmso_p dmso_p <=> dmso_c dms_e <=> dms_p dhpmp_c + h2o_c --> pi_c + dhnpt_c ahdt_c + h2o_c --> ppi_c + dhpmp_c + h_c 23doguln_c + nadh_c + h_c --> nad_c + 3dhguln_c dopa_e <=> dopa_p doxrbcn_e <=> doxrbcn_p doxrbcn_p + h_p --> doxrbcn_e + h_c dpcoa_c + atp_c --> coa_c + adp_c + h_c 2dhp_c + nadph_c + h_c --> nadp_c + pant__R_c 2dr5p_c --> acald_c + g3p_c q8_c + dsbard_p --> dsbaox_p + q8h2_c dsbard_p + mqn8_c --> dsbaox_p + mql8_c 2.0 gthrd_p + dsbcox_p --> dsbcrd_p + gthox_p trdrd_c + dsbdox_c --> dsbdrd_c + trdox_c dsbgox_p + 2.0 gthrd_p --> dsbgrd_p + gthox_p nadp_c + ser__D_c <=> 2amsa_c + nadph_c + h_c ser__D_p + h_p --> ser__D_c + h_c ser__D_e <=> ser__D_p tartr__D_c --> oaa_c + h2o_c dtmp_c + atp_c <=> dtdp_c + adp_c dtmp_e <=> dtmp_p dump_e <=> dump_p 56dura_c + nad_c <=> nadh_c + ura_c + h_c duri_c + atp_c --> dump_c + adp_c + h_c pi_c + duri_c <=> 2dr1p_c + ura_c duri_p + h_p --> duri_c + h_c duri_e <=> duri_p h2o_c + dutp_c --> dump_c + ppi_c + h_c h_c + nadph_c + dxyl5p_c --> nadp_c + 2me4p_c g3p_c + pyr_c + h_c --> co2_c + dxyl5p_c dxyl_c + atp_c --> h_c + adp_c + dxyl5p_c e4p_c + nad_c + h2o_c <=> nadh_c + 2.0 h_c + 4per_c nadh_c + h_c + tdec2eACP_c --> dcaACP_c + nad_c h_c + nadph_c + tdec2eACP_c --> dcaACP_c + nadp_c nadh_c + tddec2eACP_c + h_c --> nad_c + ddcaACP_c tddec2eACP_c + nadph_c + h_c --> nadp_c + ddcaACP_c nadh_c + t3c5ddeceACP_c + h_c --> nad_c + cddec5eACP_c t3c5ddeceACP_c + nadph_c + h_c --> nadp_c + cddec5eACP_c tmrs2eACP_c + nadh_c + h_c --> nad_c + myrsACP_c tmrs2eACP_c + nadph_c + h_c --> myrsACP_c + nadp_c nadh_c + t3c7mrseACP_c + h_c --> tdeACP_c + nad_c nadph_c + t3c7mrseACP_c + h_c --> nadp_c + tdeACP_c nadh_c + tpalm2eACP_c + h_c --> palmACP_c + nad_c nadph_c + tpalm2eACP_c + h_c --> palmACP_c + nadp_c nadh_c + t3c9palmeACP_c + h_c --> nad_c + hdeACP_c t3c9palmeACP_c + nadph_c + h_c --> nadp_c + hdeACP_c toctd2eACP_c + nadh_c + h_c --> nad_c + ocdcaACP_c toctd2eACP_c + nadph_c + h_c --> nadp_c + ocdcaACP_c t3c11vaceACP_c + h_c + nadh_c --> nad_c + octeACP_c t3c11vaceACP_c + nadph_c + h_c --> nadp_c + octeACP_c nadh_c + but2eACP_c + h_c --> butACP_c + nad_c but2eACP_c + nadph_c + h_c --> butACP_c + nadp_c nadh_c + thex2eACP_c + h_c --> hexACP_c + nad_c thex2eACP_c + nadph_c + h_c --> hexACP_c + nadp_c toct2eACP_c + h_c + nadh_c --> nad_c + ocACP_c toct2eACP_c + nadph_c + h_c --> nadp_c + ocACP_c eca4colipa_p + atp_c + h2o_c --> eca4colipa_e + h_c + pi_c + adp_c eca4und_p + colipa_p --> udcpdp_p + h_p + eca4colipa_p 2.0 unagamuf_p --> h_p + eca2und_p + udcpdp_p eca2und_p + unagamuf_p --> eca3und_p + h_p + udcpdp_p eca3und_p + unagamuf_p --> eca4und_p + h_p + udcpdp_p unagamuf_c --> unagamuf_p 3hbcoa_c <=> b2coa_c + h2o_c 3hhcoa_c <=> hx2coa_c + h2o_c 3hocoa_c <=> h2o_c + oc2coa_c 3hdcoa_c <=> dc2coa_c + h2o_c 3hddcoa_c <=> h2o_c + dd2coa_c 3htdcoa_c <=> td2coa_c + h2o_c 3hhdcoa_c <=> hdd2coa_c + h2o_c 3hodcoa_c <=> od2coa_c + h2o_c 2ddg6p_c --> g3p_c + pyr_c 6pgc_c --> 2ddg6p_c + h2o_c kdo2lipid4_c + ddcaACP_c --> ACP_c + kdo2lipid4L_c myrsACP_c + kdo2lipid4L_c --> ACP_c + lipa_c hdeACP_c + kdo2lipid4_c --> kdo2lipid4p_c + ACP_c kdo2lipid4p_c + myrsACP_c --> ACP_c + lipa_cold_c egmeACP_c + nadph_c + h_c --> nadp_c + gmeACP_c enlipa_p + atp_c + h2o_c --> enlipa_e + h_c + pi_c + adp_c 2pg_c <=> pep_c + h2o_c 3.0 seramp_c + 3.0 23dhba_c --> enter_c + 6.0 amp_c + 9.0 h_c enter_c + 3.0 h2o_c --> 3.0 23dhbzs_c + 3.0 h_c 3.0 h2o_c + feenter_c --> fe3_c + 3.0 23dhbzs_c + 3.0 h_c epmeACP_c + nadph_c + h_c --> nadp_c + pmeACP_c etha_c --> acald_c + nh4_c h_p + etha_p --> etha_c + h_c etha_e <=> etha_p ethso3_p + atp_c + h2o_c --> h_c + pi_c + adp_c + ethso3_c ethso3_e <=> ethso3_p etoh_e <=> etoh_p etoh_p <=> etoh_c f6p_c <=> g3p_c + dha_c h2o_c + f6p_c --> pi_c + fru_c f6p_p + 2.0 pi_c --> 2.0 pi_p + f6p_c f6p_e <=> f6p_p dcaACP_c + h2o_c --> ACP_c + dca_c + h_c h2o_c + ddcaACP_c --> ACP_c + ddca_c + h_c myrsACP_c + h2o_c --> ACP_c + ttdca_c + h_c tdeACP_c + h2o_c --> ttdcea_c + ACP_c + h_c palmACP_c + h2o_c --> ACP_c + hdca_c + h_c hdeACP_c + h2o_c --> ACP_c + hdcea_c + h_c ocACP_c + h2o_c --> ACP_c + octa_c + h_c dcacoa_c + h2o_c --> dca_c + coa_c + h_c ddcacoa_c + h2o_c --> coa_c + ddca_c + h_c tdcoa_c + h2o_c --> coa_c + ttdca_c + h_c tdecoa_c + h2o_c --> ttdcea_c + coa_c + h_c h2o_c + pmtcoa_c --> coa_c + hdca_c + h_c hdcoa_c + h2o_c --> coa_c + hdcea_c + h_c stcoa_c + h2o_c --> ocdca_c + coa_c + h_c h2o_c + odecoa_c --> coa_c + ocdcea_c + h_c hxcoa_c + h2o_c --> coa_c + hxa_c + h_c occoa_c + h2o_c --> coa_c + octa_c + h_c dca_p + coa_c + h_p + atp_c --> ppi_c + h_c + dcacoa_c + amp_c ddca_p + coa_c + h_p + atp_c --> ddcacoa_c + ppi_c + h_c + amp_c coa_c + ttdca_p + h_p + atp_c --> tdcoa_c + ppi_c + h_c + amp_c ttdcea_p + coa_c + h_p + atp_c --> ppi_c + h_c + tdecoa_c + amp_c coa_c + h_p + hdca_p + atp_c --> pmtcoa_c + ppi_c + h_c + amp_c atp_c + coa_c + h_p + hdcea_p --> ppi_c + h_c + hdcoa_c + amp_c coa_c + h_p + ocdca_p + atp_c --> stcoa_c + ppi_c + h_c + amp_c ocdcea_p + coa_c + h_p + atp_c --> ppi_c + h_c + odecoa_c + amp_c hxa_p + coa_c + h_p + atp_c --> ppi_c + hxcoa_c + h_c + amp_c octa_p + h_p + coa_c + atp_c --> ppi_c + h_c + occoa_c + amp_c fad_c + nadh_c + h_c --> nad_c + fadh2_c nadph_c + fad_c + h_c --> nadp_c + fadh2_c nad_c + hmgth_c <=> Sfglutth_c + nadh_c + h_c fald_e <=> fald_p fald_p <=> fald_c gthrd_c + fald_c <=> hmgth_c fdp_c <=> dhap_c + g3p_c s17bp_c <=> e4p_c + dhap_c fdp_c + h2o_c --> pi_c + f6p_c fuc__L_c <=> fcl__L_c fcl__L_c + atp_c --> fc1p_c + adp_c + h_c fc1p_c <=> dhap_c + lald__L_c fe2_c + ppp9_c --> pheme_c + 2.0 h_c 2.0 h_c + for_p + q8_c --> h_p + co2_p + q8h2_c mqn8_c + 2.0 h_c + for_p --> mql8_c + co2_p + h_p fmnh2_c + o2_c + isetac_c --> so3_c + gcald_c + h_c + fmn_c + h2o_c mso3_c + fmnh2_c + o2_c --> fald_c + so3_c + h_c + fmn_c + h2o_c fmnh2_c + ethso3_c + o2_c --> acald_c + so3_c + h_c + fmn_c + h2o_c fmnh2_c + butso3_c + o2_c --> so3_c + h_c + fmn_c + btal_c + h2o_c sulfac_c + fmnh2_c + o2_c --> so3_c + h_c + fmn_c + glx_c + h2o_c fe2_p + atp_c + h2o_c --> h_c + pi_c + fe2_c + adp_c fe2_p + h_p --> fe2_c + h_c fe2_c + h_p --> fe2_p + h_c fe2_e <=> fe2_p fe2_p --> fe2_c fe3dcit_p + h2o_c + atp_c --> fe3_c + 2.0 cit_c + h_c + pi_c + adp_c h_p + fe3dcit_e --> fe3dcit_p + h_c fe3dhbzs_c --> fe3_c + 23dhbzs_c fe3dhbzs_p + atp_c + h2o_c --> fe3dhbzs_c + h_c + pi_c + adp_c fe3dhbzs_e + h_p --> fe3dhbzs_p + h_c 2.0 fe3hox_c + fadh2_c --> fad_c + 2.0 h_c + 2.0 fe3hox_un_c + 2.0 fe2_c 2.0 fe3hox_c + fmnh2_c --> 2.0 h_c + 2.0 fe3hox_un_c + 2.0 fe2_c + fmn_c 2.0 fe3hox_c + rbflvrd_c --> 2.0 h_c + 2.0 fe3hox_un_c + 2.0 fe2_c + ribflv_c fe3hox_un_c + h_p --> fe3hox_un_p + h_c h_p + fe3hox_un_p --> fe3hox_un_e + h_c fe3hox_p + atp_c + h2o_c --> fe3hox_c + pi_c + h_c + adp_c fe3hox_un_e + fe3_e --> fe3hox_e fe3hox_e + h_p --> fe3hox_p + h_c 2.0 fe3_c + fadh2_c --> fad_c + 2.0 fe2_c + 2.0 h_c fe3_p + atp_c + h2o_c --> fe3_c + h_c + pi_c + adp_c fe3_e <=> fe3_p 2.0 fecrm_c + fadh2_c --> 2.0 h_c + fad_c + 2.0 fe2_c + 2.0 fecrm_un_c 2.0 fecrm_c + fmnh2_c --> 2.0 h_c + 2.0 fe2_c + fmn_c + 2.0 fecrm_un_c 2.0 fecrm_c + rbflvrd_c --> 2.0 h_c + 2.0 fe2_c + 2.0 fecrm_un_c + ribflv_c h_p + fecrm_un_p --> fecrm_un_e + h_c h_p + fecrm_un_c --> fecrm_un_p + h_c fecrm_p + atp_c + h2o_c --> fecrm_c + h_c + pi_c + adp_c fe3_e + fecrm_un_e --> fecrm_e fecrm_e + h_p --> fecrm_p + h_c 2.0 feenter_c + fadh2_c --> 2.0 h_c + 2.0 enter_c + fad_c + 2.0 fe2_c fmnh2_c + 2.0 feenter_c --> 2.0 h_c + 2.0 enter_c + 2.0 fe2_c + fmn_c rbflvrd_c + 2.0 feenter_c --> 2.0 h_c + 2.0 enter_c + 2.0 fe2_c + ribflv_c feenter_p + atp_c + h2o_c --> h_c + pi_c + adp_c + feenter_c fe3_e + enter_e --> feenter_e h_p + enter_p --> h_c + enter_e feenter_e + h_p --> feenter_p + h_c enter_c + h_p --> h_c + enter_p 2.0 feoxam_c + fadh2_c --> 2.0 feoxam_un_c + 2.0 h_c + fad_c + 2.0 fe2_c 2.0 feoxam_c + fmnh2_c --> 2.0 feoxam_un_c + 2.0 h_c + 2.0 fe2_c + fmn_c 2.0 feoxam_c + rbflvrd_c --> 2.0 feoxam_un_c + 2.0 h_c + 2.0 fe2_c + ribflv_c feoxam_un_p + h_p --> feoxam_un_e + h_c feoxam_un_c + h_p --> feoxam_un_p + h_c feoxam_p + atp_c + h2o_c --> feoxam_c + h_c + pi_c + adp_c feoxam_un_e + fe3_e --> feoxam_e h_p + feoxam_e --> feoxam_p + h_c 4.0 fe2_p + o2_p + 4.0 h_p --> 2.0 h2o_p + 4.0 fe3_p 2.0 4fe4s_c + 2.0 h_c + h2o2_c --> 2.0 fe3_c + 2.0 3fe4s_c + 2.0 h2o_c 2.0 4fe4s_c + 2.0 no_c + 2.0 h_c --> 2.0 fe3_c + n2o_c + 2.0 3fe4s_c + h2o_c fe2_c + 3fe4s_c --> 4fe4s_c suc6p_c + h2o_c --> g6p_c + fru_c h_c + for_c --> co2_c + h2_c nadph_c + 2.0 flxso_c --> nadp_c + 2.0 flxr_c + h_c ribflv_c + nadph_c + h_c --> rbflvrd_c + nadp_c ribflv_c + nadh_c + h_c --> rbflvrd_c + nad_c mettrna_c + 10fthf_c --> fmettrna_c + thf_c + h_c fmn_c + atp_c + h_c --> fad_c + ppi_c nadh_c + fmn_c + h_c --> fmnh2_c + nad_c fmn_c + nadph_c + h_c --> fmnh2_c + nadp_c 5fthf_c + h_c --> methf_c + h2o_c oxa_c + forcoa_c <=> oxalcoa_c + for_c for_p + h_p --> h_c + for_c for_e <=> for_p for_c --> for_p mql8_c + fum_c --> mqn8_c + succ_c 2dmmql8_c + fum_c --> 2dmmq8_c + succ_c f1p_c + atp_c --> fdp_c + adp_c + h_c h2o_c + frulysp_c <=> g6p_c + lys__L_c psclys_c <=> frulys_c frulys_c + atp_c --> h_c + adp_c + frulysp_c frulys_p + h_p --> frulys_c + h_c frulys_e <=> frulys_p fruur_p + h_p <=> fruur_c + h_c fruur_e <=> fruur_p fru_p + pep_c --> pyr_c + f6p_c fru_p + pep_c --> pyr_c + f1p_c fru_e <=> fru_p h2o_c + 10fthf_c --> h_c + thf_c + for_c thf_c + for_c + atp_c --> pi_c + 10fthf_c + adp_c fuc__L_e <=> fuc__L_p fuc__L_p + h_p <=> fuc__L_c + h_c fum_c + h2o_c <=> mal__L_c 2.0 h_p + fum_p --> fum_c + 2.0 h_c 3.0 h_p + fum_p --> fum_c + 3.0 h_c fum_e <=> fum_p fusa_e <=> fusa_p h_p + fusa_p --> fusa_e + h_c accoa_c + gam1p_c --> acgam1p_c + coa_c + h_c g1p_p + h2o_p --> glc__D_p + pi_p g1p_c + dttp_c + h_c --> dtdpglu_c + ppi_c g1p_e <=> g1p_p glu1sa_c <=> 5aop_c glyc2p_c + h2o_c --> glyc_c + pi_c glyc2p_p + h2o_p --> pi_p + glyc_p ddcaACP_c + glyc3p_c --> ACP_c + 1ddecg3p_c glyc3p_c + myrsACP_c --> 1tdecg3p_c + ACP_c glyc3p_c + tdeACP_c --> 1tdec7eg3p_c + ACP_c palmACP_c + glyc3p_c --> 1hdecg3p_c + ACP_c glyc3p_c + hdeACP_c --> 1hdec9eg3p_c + ACP_c glyc3p_c + ocdcaACP_c --> 1odecg3p_c + ACP_c glyc3p_c + octeACP_c --> 1odec11eg3p_c + ACP_c g3pc_p + atp_c + h2o_c --> h_c + pi_c + adp_c + g3pc_c g3pc_e <=> g3pc_p glyc3p_c + nadp_c <=> dhap_c + nadph_c + h_c glyc3p_c + q8_c --> dhap_c + q8h2_c glyc3p_c + mqn8_c --> dhap_c + mql8_c glyc3p_c + 2dmmq8_c --> 2dmmql8_c + dhap_c g3pe_p + atp_c + h2o_c --> h_c + g3pe_c + pi_c + adp_c g3pe_e <=> g3pe_p g3pg_p + atp_c + h2o_c --> g3pg_c + h_c + pi_c + adp_c g3pg_e <=> g3pg_p g3pi_p + atp_c + h2o_c --> g3pi_c + h_c + pi_c + adp_c g3pi_e <=> g3pi_p g3ps_p + atp_c + h2o_c --> g3ps_c + pi_c + h_c + adp_c g3ps_e <=> g3ps_p glyc3p_c + h2o_c --> glyc_c + pi_c glu5sa_c --> h_c + 1pyr5c_c + h2o_c nadph_c + h_c + glu5p_c --> pi_c + glu5sa_c + nadp_c gam6p_c + h2o_c --> nh4_c + f6p_c nadp_c + g6p_c <=> nadph_c + 6pgl_c + h_c g6p_c + h2o_c --> glc__D_c + pi_c 2.0 pi_c + g6p_p --> g6p_c + 2.0 pi_p g6p_e <=> g6p_p h2o_p + gal1p_p --> gal_p + pi_p gal1p_e <=> gal1p_p gal_bD_e <=> gal_bD_p galct__D_c --> 5dh4dglc_c + h2o_c nad_c + galctn__L_c --> nadh_c + h_c + tagur_c galctn__D_c --> 2dh3dgal_c + h2o_c h_p + galctn__L_p --> galctn__L_c + h_c galctn__L_e <=> galctn__L_p galctn__D_p + h_p --> galctn__D_c + h_c galctn__D_e <=> galctn__D_p h_p + galct__D_p <=> galct__D_c + h_c galct__D_e <=> galct__D_p gal_c + atp_c <=> adp_c + gal1p_c + h_c gal_bD_p --> gal_p h2o_c + melib_c --> glc__D_c + gal_c gicolipa_c + udpg_c --> h_c + udp_c + gagicolipa_c pep_c + galt_p --> galt1p_c + pyr_c galt_e <=> galt_p galur_p + h_p <=> h_c + galur_c galur_e <=> galur_p utp_c + g1p_c + h_c --> udpg_c + ppi_c gal_p + atp_c + h2o_c --> h_c + pi_c + adp_c + gal_c gal_p + h_p --> gal_c + h_c gal_e <=> gal_p gam6p_p + 2.0 pi_c --> 2.0 pi_p + gam6p_c gam6p_e <=> gam6p_p pep_c + gam_p --> gam6p_c + pyr_c gam_e <=> gam_p g3p_c + pi_c + nad_c <=> h_c + 13dpg_c + nadh_c 10fthf_c + gar_c <=> fgam_c + thf_c + h_c gar_c + for_c + atp_c --> fgam_c + h_c + pi_c + adp_c gbbtn_e <=> gbbtn_p gcald_c + nad_c + h2o_c --> 2.0 h_c + nadh_c + glyclt_c gdpddman_c --> gdpofuc_c gdp_c + atp_c --> amp_c + h_c + ppgpp_c h2o_c + gdpmann_c --> gdp_c + man_c + h_c h2o_c + gdpmann_c --> gmp_c + man1p_c + 2.0 h_c gdptp_c + h2o_c --> ppi_c + gtp_c gdp_e <=> gdp_p f6p_c + gln__L_c --> gam6p_c + glu__L_c nadp_c + ggbutal_c + h2o_c <=> nadph_c + 2.0 h_c + gg4abut_c gg4abut_c + h2o_c --> glu__L_c + 4abut_c ggptrc_c + o2_c + h2o_c --> h2o2_c + nh4_c + ggbutal_c ptrc_c + glu__L_c + atp_c --> ggptrc_c + h_c + pi_c + adp_c nadh_c + h_c + sucsal_c <=> nad_c + ghb_c thf_c + ser__L_c <=> gly_c + h2o_c + mlthf_c gmp_c + atp_c <=> gdp_c + adp_c glycogen_c --> bglycogen_c glc__D_c + accoa_c <=> acglc__D_c + coa_c glc__D_p + h2o_p + q8_c --> glcn_p + h_p + q8h2_c glcn_p + h_p <=> glcn_c + h_c glcn_e <=> glcn_p glycogen_c + pi_c --> g1p_c bglycogen_c + pi_c --> g1p_c 5dh4dglc_c --> pyr_c + 2h3oppan_c glcr_c --> 5dh4dglc_c + h2o_c h_p + glcr_p <=> glcr_c + h_c glcr_e <=> glcr_p adpglc_c --> glycogen_c + adp_c + h_c icolipa_c + udpg_c --> gicolipa_c + udp_c + h_c udpg_c + gagicolipa_c --> udp_c + h_c + ggagicolipa_c udpg_c + ggagicolipa_c --> gggagicolipa_c + udp_c + h_c glcur1p_e <=> glcur1p_p glcur_p + h_p <=> glcur_c + h_c glcur_e <=> glcur_p glc__D_p + atp_c + h2o_c --> h_c + glc__D_c + pi_c + adp_c pep_c + glc__D_p --> g6p_c + pyr_c glc__D_p + h_p --> glc__D_c + h_c glc__D_e <=> glc__D_p glc__D_e --> glc__D_p bglycogen_c --> glycogen_c g1p_c + atp_c + h_c --> adpglc_c + ppi_c nh4_c + glu__L_c + atp_c --> gln__L_c + h_c + pi_c + adp_c trnagln_c + gln__L_c + atp_c --> glntrna_c + ppi_c + amp_c gln__L_p + atp_c + h2o_c --> gln__L_c + h_c + pi_c + adp_c gln__L_e <=> gln__L_p galt1p_c + nad_c <=> tag6p__D_c + nadh_c + h_c glu__L_c + atp_c --> glu5p_c + adp_c glu__L_p + 4abut_c <=> 4abut_p + glu__L_c cys__L_c + glu__L_c + atp_c --> h_c + pi_c + glucys_c + adp_c glu__L_c + h_c --> 4abut_c + co2_c nadp_c + glu__L_c + h2o_c <=> h_c + akg_c + nh4_c + nadph_c gln__L_c + h2o_c --> nh4_c + glu__L_c h2o_p + gln__L_p --> nh4_p + glu__L_p prpp_c + gln__L_c + h2o_c --> pram_c + ppi_c + glu__L_c glu__D_c <=> glu__L_c h_c + akg_c + nadph_c + gln__L_c --> nadp_c + 2.0 glu__L_c nadph_c + glutrna_c + h_c --> nadp_c + glu1sa_c + trnaglu_c trnaglu_c + glu__L_c + atp_c --> glutrna_c + ppi_c + amp_c glu__L_p + atp_c + h2o_c --> h_c + pi_c + adp_c + glu__L_c h_p + glu__L_p <=> glu__L_c + h_c glu__L_p + na1_p --> glu__L_c + na1_c glu__L_e <=> glu__L_p 2.0 glx_c + h_c --> 2h3oppan_c + co2_c glyald_e <=> glyald_p glyald_p <=> glyald_c accoa_c + gly_c <=> 2aobut_c + coa_c glyb_p + atp_c + h2o_c --> glyb_c + h_c + pi_c + adp_c glyb_p + h_p --> glyb_c + h_c glyb_e <=> glyb_p glyc2p_p + atp_c + h2o_c --> h_c + glyc2p_c + pi_c + adp_c glyc2p_e <=> glyc2p_p glyc3p_p + atp_c + h2o_c --> glyc3p_c + h_c + pi_c + adp_c pi_c + glyc3p_p --> glyc3p_c + pi_p glyc3p_e <=> glyc3p_p h_p + glyc__R_p <=> h_c + glyc__R_c glyc__R_e <=> glyc__R_p glyc_c + nad_c --> h_c + nadh_c + dha_c atp_c + glyc__R_c --> adp_c + 3pg_c + h_c glyc__R_c + atp_c --> adp_c + 2pg_c + h_c thf_c + gly_c + nad_c --> nadh_c + co2_c + nh4_c + mlthf_c nadh_c + glx_c + h_c --> nad_c + glyclt_c nadph_c + glx_c + h_c --> glyclt_c + nadp_c glyclt_p + h_p <=> glyclt_c + h_c glyclt_p + na1_p --> glyclt_c + na1_c glyclt_e <=> glyclt_p q8_c + glyclt_c --> glx_c + q8h2_c mqn8_c + glyclt_c --> mql8_c + glx_c 2dmmq8_c + glyclt_c --> 2dmmql8_c + glx_c glyc_e <=> glyc_p glyc_c <=> glyc_p glyc_c + atp_c --> glyc3p_c + adp_c + h_c lgt__S_c + h2o_c --> gthrd_c + h_c + lac__D_c mthgxl_c + h2o_c --> lac__D_c + h_c trnagly_c + gly_c + atp_c --> ppi_c + amp_c + glytrna_c gly_p + h_p --> gly_c + h_c gly_p + h_p <=> gly_c + h_c gly_p + na1_p --> gly_c + na1_c gly_e <=> gly_p gdpmann_c --> gdpddman_c + h2o_c gmhep1p_c + atp_c + h_c --> adphep_DD_c + ppi_c gmhep7p_c + atp_c --> adp_c + gmhep17bp_c + h_c gmhep17bp_c + h2o_c --> gmhep1p_c + pi_c nadph_c + 2.0 h_c + gmp_c --> imp_c + nh4_c + nadp_c atp_c + h2o_c + xmp_c + gln__L_c --> 2.0 h_c + ppi_c + gmp_c + glu__L_c + amp_c gmp_e <=> gmp_p nadp_c + 6pgc_c --> ru5p__D_c + nadph_c + co2_c glcn_c + atp_c --> 6pgc_c + adp_c + h_c gdpofuc_c + nadph_c + h_c --> nadp_c + gdpfuc_c gp4g_c + h2o_c --> 2.0 gdp_c + 2.0 h_c g3pc_c + h2o_c --> glyc3p_c + chol_c + h_c g3pc_p + h2o_p --> h_p + glyc3p_p + chol_p g3pe_c + h2o_c --> glyc3p_c + etha_c + h_c g3pe_p + h2o_p --> etha_p + h_p + glyc3p_p h2o_c + g3ps_c --> glyc3p_c + h_c + ser__L_c h2o_p + g3ps_p --> h_p + glyc3p_p + ser__L_p h2o_c + g3pg_c --> glyc3p_c + glyc_c + h_c g3pg_p + h2o_p --> h_p + glyc3p_p + glyc_p h2o_c + g3pi_c --> inost_c + glyc3p_c + h_c g3pi_p + h2o_p --> glyc3p_p + h_p + inost_p grdp_c + ipdp_c --> frdp_c + ppi_c 2.0 gthrd_c + grxox_c --> grxrd_c + gthox_c gsn_c + atp_c --> gmp_c + adp_c + h_c h_p + gsn_p --> gsn_c + h_c gsn_e <=> gsn_p gtspmd_c + h2o_c --> gthrd_c + spmd_c gthrd_c + spmd_c + atp_c --> h_c + gtspmd_c + pi_c + adp_c gthox_e <=> gthox_p gthox_c + nadph_c + h_c <=> 2.0 gthrd_c + nadp_c h2o2_c + 2.0 gthrd_c --> gthox_c + 2.0 h2o_c gthrd_p + h2o_p --> cgly_p + glu__L_p gthrd_c + atp_c + h2o_c --> gthrd_p + h_c + pi_c + adp_c gthrd_p + atp_c + h2o_c --> gthrd_c + h_c + pi_c + adp_c gthrd_e <=> gthrd_p gly_c + glucys_c + atp_c --> gthrd_c + h_c + pi_c + adp_c h2o_c + gtp_c --> ahdt_c + h_c + for_c gtp_c + 3.0 h2o_c --> for_c + 2.0 h_c + ppi_c + 25drapp_c gdptp_c + h2o_c --> pi_c + h_c + ppgpp_c atp_c + gtp_c --> gdptp_c + amp_c + h_c h2o_c + gtp_c + h_c --> nh4_c + xtp_c gtp_e <=> gtp_p gtp_c --> 35cgmp_c + ppi_c h_c + h2o_c + gua_c --> xan_c + nh4_c prpp_c + gua_c --> gmp_c + ppi_c gua_p + h_p --> h_c + gua_c gua_e <=> gua_p gua_p <=> gua_c glcur_c <=> fruur_c galur_c <=> tagur_c glcur1p_p + h2o_p --> glcur_p + pi_p h2o2_e <=> h2o2_p h2o_e <=> h2o_p h2o_p <=> h2o_c h2s_c + 2.0 o2_c --> so4_c + 2.0 h_c h2s_c --> h2s_p h2s_e <=> h2s_p h2_e <=> h2_p h2_p <=> h2_c nadh_c + h_c + aacoa_c <=> nad_c + 3hbcoa_c 3ohcoa_c + h_c + nadh_c <=> nad_c + 3hhcoa_c 3oocoa_c + h_c + nadh_c <=> 3hocoa_c + nad_c 3odcoa_c + nadh_c + h_c <=> nad_c + 3hdcoa_c nadh_c + 3oddcoa_c + h_c <=> nad_c + 3hddcoa_c nadh_c + 3otdcoa_c + h_c <=> nad_c + 3htdcoa_c h_c + nadh_c + 3ohdcoa_c <=> nad_c + 3hhdcoa_c 3oodcoa_c + nadh_c + h_c <=> 3hodcoa_c + nad_c nad_c + 3hadpcoa_c <=> oxadpcoa_c + nadh_c + h_c octdp_c + 4hbz_c --> 3ophb_c + ppi_c 3hcinnm_p + h_p <=> h_c + 3hcinnm_c 3hcinnm_e <=> 3hcinnm_p co2_c + h2o_c <=> hco3_c + h_c hcys__L_c + amet_c --> met__L_c + ahcys_c + h_c hcys__L_c + mmet_c --> 2.0 met__L_c + h_c hdca_e --> hdca_p hdcea_e --> hdcea_p pheme_c + frdp_c + h2o_c --> hemeO_c + ppi_c hhlipa_c + atp_c --> phhlipa_c + adp_c + h_c hphhlipa_c + atp_c --> adp_c + phphhlipa_c + h_c adphep_LD_c + lipa_c --> adp_c + hlipa_c + h_c adphep_LD_c + hlipa_c --> hhlipa_c + adp_c + h_c adphep_LD_c + phhlipa_c --> h_c + hphhlipa_c + adp_c gggagicolipa_c + adphep_LD_c --> colipa_c + adp_c + h_c 4mhetz_c + atp_c --> adp_c + 4mpetz_c + h_c glc__D_c + atp_c --> g6p_c + adp_c + h_c atp_c + man_c --> man6p_c + adp_c + h_c atp_c + fru_c --> adp_c + h_c + f6p_c h_p + hxa_p <=> hxa_c + h_c hg2_c + atp_c + h2o_c --> hg2_p + h_c + pi_c + adp_c h_p + hg2_c --> hg2_p + h_c hg2_e <=> hg2_p histd_c + 2.0 nad_c + h2o_c --> his__L_c + 3.0 h_c + 2.0 nadh_c hisp_c + h2o_c --> pi_c + histd_c his__L_c + trnahis_c + atp_c --> histrna_c + ppi_c + amp_c his__L_p + atp_c + h2o_c --> his__L_c + h_c + pi_c + adp_c h_p + his__L_p <=> his__L_c + h_c his__L_e <=> his__L_p h2o_c + hkndd_c --> h_c + op4en_c + succ_c hkntd_c + h2o_c --> fum_c + op4en_c + h_c 4.0 ppbng_c + h2o_c --> hmbil_c + 4.0 nh4_c 4ahmmp_c + atp_c --> adp_c + 4ampm_c + h_c hom__L_c + h_p --> hom__L_p + h_c hom__L_e <=> hom__L_p 4h2opntn_c --> pyr_c + acald_c atp_c + 6hmhpt_c --> amp_c + 6hmhptpp_c + h_c dhpppn_c + o2_c --> h_c + hkndd_c h_p + 3hpppn_p <=> 3hpppn_c + h_c 3hpppn_e <=> 3hpppn_p hpyr_c <=> 2h3oppan_c hpyr_c + nadh_c + h_c --> nad_c + glyc__R_c hpyr_c + nadph_c + h_c --> nadp_c + glyc__R_c hom__L_c + nadp_c <=> aspsa_c + nadph_c + h_c hom__L_c + atp_c --> adp_c + phom_c + h_c hom__L_c + succoa_c --> suchms_c + coa_c glu__L_c + imacp_c --> akg_c + hisp_c hxan_c + nad_c + h2o_c --> h_c + xan_c + nadh_c hxa_e <=> hxa_p accoa_c + hxa_c --> hxcoa_c + ac_c hxan_c + prpp_c --> imp_c + ppi_c q8_c + 2.0 h_c + h2_c --> 2.0 h_p + q8h2_c mqn8_c + h2_c + 2.0 h_c --> 2.0 h_p + mql8_c 2dmmq8_c + h2_c + 2.0 h_c --> 2dmmql8_c + 2.0 h_p h2o_c + pyam5p_c --> pi_c + pydam_c hxan_e <=> hxan_p hxan_p <=> hxan_c h_e <=> h_p iscssh_c + 2fe1s_c + iscu_c --> iscs_c + 4.0 h_c + iscu_2fe2s_c 2.0 iscssh_c + 2.0 fe2_c + iscu_c + fadh2_c --> 2.0 iscs_c + 6.0 h_c + fad_c + iscu_2fe2s_c 2.0 iscssh_c + iscu_2fe2s_c + 2.0 fe2_c + fadh2_c --> iscu_2fe2s2_c + 2.0 iscs_c + 6.0 h_c + fad_c iscu_2fe2s_c + 4.0 h_c --> 2fe2s_c + iscu_c iscu_2fe2s2_c + fadh2_c + 2.0 h_c --> fad_c + iscu_4fe4s_c iscu_4fe4s_c + 4.0 h_c --> 4fe4s_c + iscu_c nadp_c + icit_c <=> nadph_c + akg_c + co2_c chor_c <=> ichor_c chor_c --> ichor_c h2o_c + ichor_c --> pyr_c + 23ddhb_c icit_c --> glx_c + succ_c iscs_c + cys__L_c --> ala__L_c + iscssh_c nadh_c + 5dglcn_c + h_c <=> nad_c + idon__L_c nadph_c + 5dglcn_c + h_c --> nadp_c + idon__L_c idon__L_p + h_p <=> idon__L_c + h_c idon__L_e <=> idon__L_p prlp_c + gln__L_c --> h_c + aicar_c + glu__L_c + eig3p_c eig3p_c --> h2o_c + imacp_c 2cpr5p_c + h_c --> co2_c + 3ig3p_c + h2o_c ile__L_c + akg_c <=> glu__L_c + 3mop_c ile__L_c + trnaile_c + atp_c --> ppi_c + iletrna_c + amp_c ile__L_p + atp_c + h2o_c --> h_c + ile__L_c + pi_c + adp_c h_p + ile__L_p <=> ile__L_c + h_c ile__L_e <=> ile__L_p imp_c + h2o_c <=> fprica_c imp_c + nad_c + h2o_c --> nadh_c + h_c + xmp_c imp_e <=> imp_p h_c + indole_c --> h_p + indole_p h_p + indole_p <=> h_c + indole_c indole_e <=> indole_p inost_p + na1_p --> inost_c + na1_c ins_c + h2o_c --> hxan_c + rib__D_c ins_c + atp_c --> imp_c + adp_c + h_c inost_e <=> inost_p ins_p + h_p --> ins_c + h_c ins_p + h_p <=> ins_c + h_c ins_e <=> ins_p ipdp_c <=> dmpp_c h2mb4p_c + h_c + nadh_c --> nad_c + ipdp_c + h2o_c nad_c + 3c2hmp_c --> nadh_c + h_c + 3c4mop_c 3c2hmp_c <=> 2ippm_c + h2o_c h2o_c + 2ippm_c <=> 3c3hmp_c 3mob_c + accoa_c + h2o_c --> 3c3hmp_c + h_c + coa_c isetac_p + atp_c + h2o_c --> h_c + pi_c + adp_c + isetac_c isetac_e <=> isetac_p kdo2lipid4_c + atp_c + h2o_c --> kdo2lipid4_p + h_c + pi_c + adp_c kdo2lipid4_p + atp_c + h2o_c --> h_c + kdo2lipid4_e + pi_c + adp_c nadp_c + 23dhmb_c <=> alac__S_c + nadph_c + h_c 2ahbut_c + nadph_c + h_c <=> nadp_c + 23dhmp_c h_c + acACP_c + malACP_c --> co2_c + actACP_c + ACP_c h_c + malACP_c + accoa_c --> co2_c + actACP_c + coa_c kdo_c + ctp_c --> ckdo_c + ppi_c h2o_c + kdo8p_c --> pi_c + kdo_c ara5p_c + pep_c + h2o_c --> pi_c + kdo8p_c 3dhgulnp_c + h_c --> xu5p__L_c + co2_c k_p + atp_c + h2o_c --> k_c + h_c + pi_c + adp_c h_p + k_p --> k_c + h_c k_c + h_p --> k_p + h_c k_e <=> k_p lac__L_c + q8_c --> pyr_c + q8h2_c lac__L_c + mqn8_c --> pyr_c + mql8_c h_p + lac__L_p <=> lac__L_c + h_c lac__L_e <=> lac__L_p uLa4n_p + colipa_p --> acolipa_p + udcpp_p lcts_c + h2o_c --> glc__D_c + gal_c lcts_p + h2o_p --> glc__D_p + gal_p h2o_c + LalaDgluMdap_c --> LalaDglu_c + 26dap__M_c LalaDglu_e <=> LalaDglu_p h_p + LalaDglu_p --> LalaDglu_c + h_c LalaLglu_e <=> LalaLglu_p LalaLglu_p + h_p --> LalaLglu_c + h_c nadh_c + h_c + mthgxl_c --> lald__D_c + nad_c mthgxl_c + nadph_c + h_c --> lald__L_c + nadp_c LalaLglu_c + h2o_c --> ala__L_c + glu__L_c lald__L_c + nad_c + h2o_c --> lac__L_c + 2.0 h_c + nadh_c lald__D_c + h_c + nadh_c <=> nad_c + 12ppd__R_c lald__L_c + nadh_c + h_c <=> nad_c + 12ppd__S_c lcts_c + h_p --> lcts_p + h_c lcts_e <=> lcts_p lcts_p + h_p <=> lcts_c + h_c nad_c + lac__D_c <=> h_c + nadh_c + pyr_c lac__D_c + q8_c --> pyr_c + q8h2_c glu__L_c + 4mop_c --> akg_c + leu__L_c trnaleu_c + atp_c + leu__L_c --> leutrna_c + ppi_c + amp_c leu__L_p + atp_c + h2o_c --> pi_c + h_c + leu__L_c + adp_c leu__L_p + h_p <=> h_c + leu__L_c leu__L_e <=> leu__L_p gthrd_c + mthgxl_c --> lgt__S_c lipa_cold_c + atp_c + h2o_c --> lipa_cold_p + h_c + pi_c + adp_c h_e + hdca_e + colipa_e --> h2o_e + hacolipa_e h_e + lipa_e + hdca_e --> halipa_e + h2o_e lipoamp_c --> amp_c + lipopb_c lipoate_c + atp_c --> ppi_c + lipoamp_c lipa_c + atp_c + h2o_c --> lipa_p + h_c + pi_c + adp_c lipa_p + atp_c + h2o_c --> lipa_e + h_c + pi_c + adp_c h_c + ocACP_c --> ACP_c + octapb_c h_c + 4fe4s_c + nad_c + 2.0 amet_c + octapb_c --> 2fe2s_c + 2.0 met__L_c + nadh_c + lipopb_c + 2.0 dad_5_c + 2.0 fe2_c h_p + lipoate_p --> lipoate_c + h_c lipoate_e <=> lipoate_p lipidX_c + u23ga_c --> udp_c + lipidAds_c + h_c h2o_p + 1ddecg3p_p --> ddca_p + h_p + glyc3p_p 1tdecg3p_p + h2o_p --> h_p + glyc3p_p + ttdca_p 1tdec7eg3p_p + h2o_p --> ttdcea_p + h_p + glyc3p_p 1hdecg3p_p + h2o_p --> glyc3p_p + hdca_p + h_p 1hdec9eg3p_p + h2o_p --> h_p + glyc3p_p + hdcea_p 1odecg3p_p + h2o_p --> h_p + glyc3p_p + ocdca_p 1odec11eg3p_p + h2o_p --> glyc3p_p + h_p + ocdcea_p 1agpe120_p + h2o_p --> ddca_p + g3pe_p + h_p h2o_p + 1agpe140_p --> g3pe_p + h_p + ttdca_p 1agpe141_p + h2o_p --> ttdcea_p + h_p + g3pe_p h2o_p + 1agpe160_p --> g3pe_p + hdca_p + h_p 1agpe161_p + h2o_p --> g3pe_p + h_p + hdcea_p 1agpe180_p + h2o_p --> g3pe_p + h_p + ocdca_p h2o_p + 1agpe181_p --> g3pe_p + h_p + ocdcea_p 1agpg120_p + h2o_p --> ddca_p + h_p + g3pg_p 1agpg140_p + h2o_p --> h_p + g3pg_p + ttdca_p 1agpg141_p + h2o_p --> ttdcea_p + h_p + g3pg_p 1agpg160_p + h2o_p --> hdca_p + h_p + g3pg_p 1agpg161_p + h2o_p --> h_p + g3pg_p + hdcea_p 1agpg180_p + h2o_p --> h_p + g3pg_p + ocdca_p 1agpg181_p + h2o_p --> g3pg_p + h_p + ocdcea_p 2ddecg3p_c + h2o_c --> glyc3p_c + ddca_c + 2.0 h_c h2o_c + 2tdecg3p_c --> glyc3p_c + 2.0 h_c + ttdca_c h2o_c + 2tdec7eg3p_c --> ttdcea_c + glyc3p_c + 2.0 h_c 2hdecg3p_c + h2o_c --> 2.0 h_c + hdca_c + glyc3p_c h2o_c + 2hdec9eg3p_c --> glyc3p_c + hdcea_c + 2.0 h_c h2o_c + 2odecg3p_c --> glyc3p_c + 2.0 h_c + ocdca_c 2odec11eg3p_c + h2o_c --> glyc3p_c + ocdcea_c + 2.0 h_c 2agpe120_c + pg120_c --> g3pe_c + apg120_c 2agpe140_c + pg140_c --> apg140_c + g3pe_c pg141_c + 2agpe141_c --> g3pe_c + apg141_c pg160_c + 2agpe160_c --> g3pe_c + apg160_c 2agpe161_c + pg161_c --> g3pe_c + apg161_c 2agpe180_c + pg180_c --> g3pe_c + apg180_c pg181_c + 2agpe181_c --> g3pe_c + apg181_c pg120_c + 2agpg120_c --> apg120_c + g3pg_c 2agpg140_c + pg140_c --> apg140_c + g3pg_c pg141_c + 2agpg141_c --> g3pg_c + apg141_c pg160_c + 2agpg160_c --> g3pg_c + apg160_c pg161_c + 2agpg161_c --> apg161_c + g3pg_c 2agpg180_c + pg180_c --> apg180_c + g3pg_c pg181_c + 2agpg181_c --> g3pg_c + apg181_c 2agpe120_c + h2o_c --> g3pe_c + ddca_c + h_c 2agpe140_c + h2o_c --> g3pe_c + h_c + ttdca_c h2o_c + 2agpe141_c --> g3pe_c + ttdcea_c + h_c h2o_c + 2agpe160_c --> g3pe_c + hdca_c + h_c 2agpe161_c + h2o_c --> g3pe_c + hdcea_c + h_c h2o_c + 2agpe180_c --> g3pe_c + ocdca_c + h_c h2o_c + 2agpe181_c --> g3pe_c + ocdcea_c + h_c h2o_c + 2agpg120_c --> g3pg_c + ddca_c + h_c h2o_c + 2agpg140_c --> g3pg_c + ttdca_c + h_c h2o_c + 2agpg141_c --> ttdcea_c + g3pg_c + h_c h2o_c + 2agpg160_c --> g3pg_c + hdca_c + h_c h2o_c + 2agpg161_c --> h_c + g3pg_c + hdcea_c 2agpg180_c + h2o_c --> ocdca_c + g3pg_c + h_c 2agpg181_c + h2o_c --> ocdcea_c + g3pg_c + h_c nadp_c + ser__L_c <=> 2amsa_c + nadph_c + h_c lys__L_c + h_c --> 15dap_c + co2_c lys__L_c + atp_c + trnalys_c --> ppi_c + amp_c + lystrna_c lys__L_p + atp_c + h2o_c --> lys__L_c + h_c + pi_c + adp_c lys__L_p + h_p --> lys__L_c + h_c lys__L_c + h_p --> lys__L_p + h_c lys__L_e <=> lys__L_p lyx__L_c --> xylu__L_c h_p + lyx__L_p --> lyx__L_c + h_c lyx__L_e <=> lyx__L_p mnl1p_c + nad_c <=> nadh_c + f6p_c + h_c h_c + malACP_c --> acACP_c + co2_c malcoa_c + amet_c --> ahcys_c + malcoame_c nad_c + mal__D_c --> nadh_c + pyr_c + co2_c mal__D_p + 2.0 h_p --> mal__D_c + 2.0 h_c mal__D_e <=> mal__D_p accoa_c + glx_c + h2o_c --> mal__L_c + h_c + coa_c malt_c + accoa_c <=> coa_c + acmalt_c malthx_p + atp_c + h2o_c --> h_c + malthx_c + pi_c + adp_c malthx_e --> malthx_p maltpt_p + atp_c + h2o_c --> maltpt_c + h_c + pi_c + adp_c maltpt_e --> maltpt_p malttr_p + atp_c + h2o_c --> h_c + malttr_c + pi_c + adp_c malttr_e --> malttr_p maltttr_p + atp_c + h2o_c --> h_c + maltttr_c + adp_c + pi_c maltttr_e --> maltttr_p malt_p + atp_c + h2o_c --> h_c + malt_c + pi_c + adp_c pep_c + malt_p --> pyr_c + malt6p_c malt_e --> malt_p mal__L_p + 2.0 h_p --> mal__L_c + 2.0 h_c mal__L_p + 3.0 h_p --> mal__L_c + 3.0 h_c mal__L_c + h_p --> mal__L_p + h_c mal__L_e <=> mal__L_p man1p_c + gdp_c + h_c --> pi_c + gdpmann_c man6p_c <=> f6p_c 2.0 pi_c + man6p_p --> man6p_c + 2.0 pi_p man6p_e <=> man6p_p mana_c + nad_c <=> nadh_c + fruur_c + h_c pep_c + manglyc_p --> pyr_c + man6pglyc_c manglyc_e <=> manglyc_p man6pglyc_c + h2o_c --> man6p_c + glyc__R_c pep_c + man_p --> pyr_c + man6p_c man_e <=> man_p 2mcit_c --> 2mcacn_c + h2o_c micit_c <=> pyr_c + succ_c oaa_c + ppcoa_c + h2o_c --> h_c + coa_c + 2mcit_c ACP_c + malcoa_c <=> coa_c + malACP_c mercppyr_c + cyan_c --> tcynt_c + pyr_c + h_c murein5p5p_p --> murein5px4p_p + ala__D_p murein5p5p_p --> alaala_p + murein5px3p_p murein5p5p5p_p --> murein5px4px4p_p + 2.0 ala__D_p murein5px4p_p + h2o_p --> murein4px4p_p + ala__D_p murein5px4px4p_p + h2o_p --> murein4px4px4p_p + ala__D_p h2o_p + murein5p5p_p --> murein5p4p_p + ala__D_p h2o_p + murein5p4p_p --> murein4p4p_p + ala__D_p murein5p3p_p + h2o_p --> murein4p3p_p + ala__D_p murein4px4p_p + h2o_p --> murein4p4p_p murein3px4p_p + h2o_p --> murein4p3p_p murein5px4p_p + h2o_p --> murein5p4p_p murein4px4px4p_p + h2o_p --> murein4px4p4p_p nad_c + mal__L_c <=> oaa_c + nadh_c + h_c mal__L_c + q8_c --> oaa_c + q8h2_c mal__L_c + mqn8_c --> oaa_c + mql8_c nad_c + mal__L_c --> nadh_c + pyr_c + co2_c nadp_c + mal__L_c --> nadph_c + pyr_c + co2_c 2mecdp_c + h_c + 2.0 flxr_c --> 2.0 flxso_c + h2mb4p_c + h2o_c 2p4c2me_c --> 2mecdp_c + cmp_c melib_p + h_p --> melib_c + h_c h_p + melib_c --> melib_p + h_c melib_e <=> melib_p meoh_e <=> meoh_p meoh_p <=> meoh_c h_c + 2me4p_c + ctp_c --> 4c2me_c + ppi_c met__L_c + atp_c + h2o_c --> ppi_c + pi_c + amet_c h2o_c + met__D_p + atp_c --> adp_c + h_c + pi_c + met__D_c met__D_e <=> met__D_p h2o2_c + met__L_c --> metsox_S__L_c + h2o_c h2o2_c + met__L_c --> metsox_R__L_c + h2o_c 5mthf_c + hcys__L_c --> met__L_c + thf_c + h_c metsox_S__L_p + atp_c + h2o_c --> metsox_S__L_c + h_c + pi_c + adp_c metsox_S__L_e <=> metsox_S__L_p metsox_R__L_p + atp_c + h2o_c --> h_c + pi_c + adp_c + metsox_R__L_c metsox_R__L_e <=> metsox_R__L_p trdrd_c + metsox_S__L_c --> met__L_c + trdox_c + h2o_c trdrd_c + metsox_R__L_c --> met__L_c + trdox_c + h2o_c trnamet_c + met__L_c + atp_c --> ppi_c + mettrna_c + amp_c met__L_p + atp_c + h2o_c --> h_c + met__L_c + pi_c + adp_c met__L_e <=> met__L_p mg2_p + 2.0 h_c <=> mg2_c + 2.0 h_p mg2_e <=> mg2_p mg2_p --> mg2_c mg2_p + atp_c + h2o_c --> mg2_c + h_c + pi_c + adp_c dhap_c --> pi_c + mthgxl_c mi1p__D_c + h2o_c --> inost_c + pi_c 2mcacn_c + h2o_c <=> micit_c mincyc_e <=> mincyc_p mincyc_p + h_p --> mincyc_e + h_c minohp_e --> minohp_p murein5px4p_p + h2o_p --> murein3px4p_p + alaala_p murein4p4p_p + h2o_p --> murein4p3p_p + ala__D_p h2o_p + murein5p5p_p --> murein5p3p_p + alaala_p murein4p3p_p + h2o_p --> murein3p3p_p + ala__D_p murein5px3p_p + h2o_p --> alaala_p + murein3px3p_p murein3px3p_p + h2o_p --> murein3p3p_p murein5px3p_p + h2o_p --> murein5p3p_p malttr_c + h2o_c --> glc__D_c + malt_c maltttr_c + h2o_c --> glc__D_c + malttr_c maltpt_c + h2o_c --> glc__D_c + maltttr_c h2o_c + malthx_c --> glc__D_c + maltpt_c h2o_c + malthp_c --> glc__D_c + malthx_c murein4p4p_p --> 2.0 anhgm4p_p murein4p3p_p --> anhgm3p_p + anhgm4p_p murein3p3p_p --> 2.0 anhgm3p_p murein4px4p4p_p --> murein4px4p_p + anhgm4p_p pi_c + maltpt_c <=> maltttr_c + g1p_c pi_c + malthx_c <=> maltpt_c + g1p_c malthp_c + pi_c <=> g1p_c + malthx_c mmcoa__S_c + h_c --> co2_c + ppcoa_c h_p + mmet_p --> h_c + mmet_c mmet_e <=> mmet_p succoa_c --> mmcoa__S_c mn2_c + h_p --> mn2_p + h_c mn2_p --> mn2_c man6p_c + h2o_c --> pi_c + man_c pep_c + mnl_p --> mnl1p_c + pyr_c mnl_e <=> mnl_p mana_c --> h2o_c + 2ddglcn_c h_p + mn2_p --> mn2_c + h_c mn2_e <=> mn2_p iscssh_c + moadamp_c + nadh_c --> iscs_c + moadcosh_c + nad_c + amp_c lipidA_c + ckdo_c --> kdolipid4_c + cmp_c + h_c ckdo_c + kdolipid4_c --> kdo2lipid4_c + cmp_c + h_c phphhlipa_c + ckdo_c --> cmp_c + kphphhlipa_c + h_c mobd_p + atp_c + h2o_c --> mobd_c + pi_c + h_c + adp_c mobd_e <=> mobd_p h_c + moco_c + ctp_c --> mococdp_c + ppi_c mptamp_c + mobd_c + 2.0 h_c --> amp_c + cu2_c + moco_c + h2o_c gtp_c + moco_c + h_c --> mocogdp_c + ppi_c 3mob_c + mlthf_c + h2o_c --> 2dhp_c + thf_c mal__L_c + o2_c <=> h2o2_c + oaa_c mpt_c + atp_c + h_c --> mptamp_c + ppi_c 2.0 uaagmda_c --> 2.0 udcpdp_c + murein5p5p_p + 2.0 h_c uaagmda_c + murein5p5p_p --> murein5p5p5p_p + udcpdp_c + h_c cpmp_c + 2.0 moadcosh_c + cu2_c --> 2.0 moadcoo_c + 5.0 h_c + mpt_c moadcoo_c + atp_c + h_c --> moadamp_c + ppi_c msa_c + nadph_c + h_c --> 3hpp_c + nadp_c mso3_p + atp_c + h2o_c --> mso3_c + h_c + pi_c + adp_c mso3_e <=> mso3_p h2o_c + 5mta_c --> ade_c + 5mtr_c methf_c + h2o_c <=> 10fthf_c + h_c nadp_c + mlthf_c <=> methf_c + nadph_c nadh_c + mlthf_c + 2.0 h_c --> 5mthf_c + nad_c mdhdhf_c + h2o_c --> mththf_c Nmtrp_c + o2_c + h2o_c --> trp__L_c + h2o2_c + fald_c n2o_e <=> n2o_p n2o_p <=> n2o_c acg5sa_c + h2o_c --> ac_c + glu5sa_c nac_e <=> nac_p nac_p --> nac_c nad_c + h2o_c --> amp_c + 2.0 h_c + nmn_c nadh_c + mqn8_c + h_c --> mql8_c + nad_c 4.0 h_c + nadh_c + q8_c --> 3.0 h_p + nad_c + q8h2_c mqn8_c + 4.0 h_c + nadh_c --> mql8_c + nad_c + 3.0 h_p 4.0 h_c + nadh_c + 2dmmq8_c --> 2dmmql8_c + nad_c + 3.0 h_p nadh_c + q8_c + h_c --> nad_c + q8h2_c nadh_c + 2dmmq8_c + h_c --> 2dmmql8_c + nad_c nad_c + atp_c --> nadp_c + adp_c + h_c nad_c + h2o_c --> ncam_c + adprib_c + h_c h_c + q8_c + nadph_c --> nadp_c + q8h2_c mqn8_c + nadph_c + h_c --> nadp_c + mql8_c nadph_c + 2dmmq8_c + h_c --> 2dmmql8_c + nadp_c nadp_c + h2o_c --> pi_c + nad_c dnad_c + nh4_c + atp_c --> ppi_c + h_c + nad_c + amp_c nadph_c + nad_c --> nadp_c + nadh_c nac_c + h2o_c + prpp_c + atp_c --> ppi_c + nicrnt_c + pi_c + adp_c 3.0 h_p + 2.0 na1_c --> 3.0 h_c + 2.0 na1_p 2.0 h_p + na1_c --> 2.0 h_c + na1_p h_p + na1_c --> h_c + na1_p na1_e <=> na1_p gdp_c + atp_c <=> gtp_c + adp_c udp_c + atp_c <=> utp_c + adp_c cdp_c + atp_c <=> adp_c + ctp_c dtdp_c + atp_c <=> dttp_c + adp_c dgdp_c + atp_c <=> dgtp_c + adp_c dudp_c + atp_c <=> dutp_c + adp_c atp_c + dcdp_c <=> dctp_c + adp_c dadp_c + atp_c <=> datp_c + adp_c nh4_e <=> nh4_p nh4_p <=> nh4_c h_c + 2.0 no_c + nadh_c --> n2o_c + nad_c + h2o_c ni2_c + atp_c + h2o_c --> ni2_p + h_c + pi_c + adp_c ni2_c + h_p --> ni2_p + h_c ni2_e <=> ni2_p ni2_p --> ni2_c ni2_p + atp_c + h2o_c --> ni2_c + h_c + pi_c + adp_c nmn_c + atp_c + h_c --> nad_c + ppi_c nmn_c + h2o_c --> nicrnt_c + nh4_c nmn_c + h2o_c --> h_c + ncam_c + r5p_c nmn_p --> nmn_c h2o_c + nmn_p --> h_c + r5p_c + ncam_c nmn_e <=> nmn_p ncam_c + h2o_c --> nh4_c + nac_c nicrnt_c + atp_c + h_c <=> dnad_c + ppi_c dmbzid_c + nicrnt_c --> nac_c + 5prdmbz_c + h_c quln_c + 2.0 h_c + prpp_c --> ppi_c + nicrnt_c + co2_c no2_p + h_p <=> no2_c + h_c no2_e <=> no2_p no3_p + q8h2_c --> h2o_p + no2_p + q8_c no3_c + 2.0 h_c + q8h2_c --> no2_c + 2.0 h_p + h2o_c + q8_c mql8_c + no3_p --> no2_p + mqn8_c + h2o_p no3_c + 2.0 h_c + mql8_c --> no2_c + mqn8_c + 2.0 h_p + h2o_c no2_c + no3_p --> no3_c + no2_p no3_e <=> no3_p 2.0 no_c + nadh_c + 2.0 o2_c --> 2.0 no3_c + h_c + nad_c 2.0 no_c + 2.0 o2_c + nadph_c --> 2.0 no3_c + nadp_c + h_c novbcn_e <=> novbcn_p novbcn_p + h_p --> novbcn_e + h_c no_e <=> no_p no_p <=> no_c dump_c + h2o_c --> duri_c + pi_c xmp_c + h2o_c --> pi_c + xtsn_c xmp_p + h2o_p --> pi_p + xtsn_p imp_c + h2o_c --> pi_c + ins_c imp_p + h2o_p --> ins_p + pi_p dimp_c + h2o_c --> pi_c + din_c dimp_p + h2o_p --> din_p + pi_p dump_p + h2o_p --> duri_p + pi_p ump_c + h2o_c --> pi_c + uri_c h2o_p + ump_p --> pi_p + uri_p dcmp_c + h2o_c --> dcyt_c + pi_c h2o_p + dcmp_p --> pi_p + dcyt_p cmp_c + h2o_c --> pi_c + cytd_c h2o_p + cmp_p --> cytd_p + pi_p dtmp_c + h2o_c --> pi_c + thymd_c dtmp_p + h2o_p --> thymd_p + pi_p damp_c + h2o_c --> pi_c + dad_2_c damp_p + h2o_p --> dad_2_p + pi_p h2o_c + amp_c --> pi_c + adn_c amp_p + h2o_p --> pi_p + adn_p dgmp_c + h2o_c --> dgsn_c + pi_c dgmp_p + h2o_p --> dgsn_p + pi_p gmp_c + h2o_c --> pi_c + gsn_c gmp_p + h2o_p --> pi_p + gsn_p h2o_c + atp_c --> pi_c + adp_c + h_c itp_c + h2o_c --> pi_c + idp_c + h_c h2o_c + ditp_c --> pi_c + didp_c + h_c h2o_c + xtp_c --> xdp_c + pi_c + h_c h2o_c + gtp_c --> pi_c + gdp_c + h_c gtp_p + h2o_p --> pi_p + h_p + gdp_p ctp_c + h2o_c --> pi_c + cdp_c + h_c dgtp_c + h2o_c --> dgmp_c + ppi_c + h_c h2o_c + ditp_c --> dimp_c + ppi_c + h_c h2o_c + xtp_c --> xmp_c + ppi_c + h_c h2o_c + gtp_c --> gmp_c + ppi_c + h_c dctp_c + h2o_c --> dcmp_c + ppi_c + h_c h2o_c + ctp_c --> h_c + ppi_c + cmp_c h2o_c + datp_c --> ppi_c + damp_c + h_c atp_c + h2o_c --> amp_c + h_c + ppi_c h2o_c + dttp_c --> dtmp_c + ppi_c + h_c h2o_c + utp_c --> ump_c + ppi_c + h_c itp_c + h2o_c --> imp_c + ppi_c + h_c dgtp_c + h2o_c --> pppi_c + dgsn_c gtp_c + h2o_c --> pppi_c + gsn_c no2_c + 5.0 h_c + 3.0 nadh_c --> 3.0 nad_c + nh4_c + 2.0 h2o_c no2_p + 2.0 h_p + 3.0 q8h2_c --> nh4_p + 2.0 h2o_p + 3.0 q8_c no2_p + 3.0 mql8_c + 2.0 h_p --> 3.0 mqn8_c + 2.0 h2o_p + nh4_p o16a4colipa_p + atp_c + h2o_c --> o16a4colipa_e + h_c + pi_c + adp_c o16a4und_p + colipa_p --> h_p + o16a4colipa_p + udcpdp_p 2.0 o16aund_p --> h_p + o16a2und_p + udcpdp_p o16a2und_p + o16aund_p --> h_p + udcpdp_p + o16a3und_p o16aund_p + o16a3und_p --> o16a4und_p + h_p + udcpdp_p accoa_c + ragund_c --> coa_c + aragund_c o16aund_c --> o16aund_p garagund_c + udpgalfur_c --> gfgaragund_c + udp_c + h_c aragund_c + udpg_c --> garagund_c + udp_c + h_c gfgaragund_c + udpg_c --> h_c + udp_c + o16aund_c o2s_e <=> o2s_p o2_e <=> o2_p o2_p <=> o2_c oaa_c + h_c --> pyr_c + co2_c 2obut_c + coa_c --> ppcoa_c + for_c cbp_c + orn_c <=> pi_c + h_c + citr__L_c ocdca_e --> ocdca_p ocdcea_e --> ocdcea_p octa_e <=> octa_p frdp_c + 5.0 ipdp_c --> octdp_c + 5.0 ppi_c h_c + atp_c + octa_c --> ppi_c + amp_c + octapb_c hgmeACP_c --> egmeACP_c + h2o_c ogmeACP_c + nadph_c + h_c --> nadp_c + hgmeACP_c h_c + malACP_c + malcoame_c --> ogmeACP_c + coa_c + co2_c ohpb_c + glu__L_c <=> akg_c + phthr_c amet_c + 2ohph_c --> 2omph_c + ahcys_c + h_c 2ombzl_c + amet_c --> 2ommbl_c + ahcys_c + h_c h_c + 3c4mop_c --> co2_c + 4mop_c 0.5 o2_c + 2ommbl_c --> 2omhmbl_c 3.0 h2o_c + nad_c + 2ommbl_c + 2.0 atp_c --> 3.0 h_c + 2.0 pi_c + 2omhmbl_c + nadh_c + 2.0 adp_c orot5p_c + h_c --> co2_c + ump_c 2omph_c + 0.5 o2_c --> 2ombzl_c 2omph_c + 3.0 h2o_c + nad_c + 2.0 atp_c --> 3.0 h_c + 2ombzl_c + 2.0 pi_c + nadh_c + 2.0 adp_c op4en_c + h2o_c --> 4h2opntn_c 3ophb_c + h_c --> co2_c + 2oph_c 0.5 o2_c + 2oph_c --> 2ohph_c 2oph_c + 3.0 h2o_c + nad_c + 2.0 atp_c --> 2ohph_c + 3.0 h_c + 2.0 pi_c + nadh_c + 2.0 adp_c hpmeACP_c --> epmeACP_c + h2o_c nadph_c + opmeACP_c + h_c --> nadp_c + hpmeACP_c gmeACP_c + h_c + malACP_c --> co2_c + opmeACP_c + ACP_c orn_c + h_c --> co2_c + ptrc_c orn_p + atp_c + h2o_c --> h_c + orn_c + pi_c + adp_c orn_e <=> orn_p orot_p + 2.0 h_p --> orot_c + 2.0 h_c orot_e <=> orot_p ppi_c + orot5p_c <=> prpp_c + orot_c pi_c + oxur_c --> cbp_c + oxam_c oxalcoa_c + h_c --> forcoa_c + co2_c nadp_c + 2oxpaccoa_c + 2.0 h2o_c --> 3oxdhscoa_c + 2.0 h_c + nadph_c coa_c + 3oxdhscoa_c --> accoa_c + 23dhacoa_c nad_c + 1pyr5c_c + 2.0 h2o_c --> h_c + nadh_c + glu__L_c 1pyr5c_c + nadph_c + 2.0 h_c --> pro__L_c + nadp_c pa120_c + atp_c + h2o_c --> h_c + pi_c + adp_c + pa120_p pa140_c + atp_c + h2o_c --> h_c + pi_c + adp_c + pa140_p pa141_c + h2o_c + atp_c --> h_c + pi_c + adp_c + pa141_p pa160_c + atp_c + h2o_c --> pa160_p + h_c + pi_c + adp_c h2o_c + atp_c + pa161_c --> pa161_p + h_c + pi_c + adp_c pa180_c + atp_c + h2o_c --> h_c + pi_c + adp_c + pa180_p pa181_c + atp_c + h2o_c --> h_c + pi_c + adp_c + pa181_p pacald_p + h_p <=> pacald_c + h_c pacald_e <=> pacald_p phaccoa_c + h_c + o2_c + nadph_c --> nadp_c + rephaccoa_c + h2o_c pac_c + coa_c + atp_c --> ppi_c + phaccoa_c + amp_c ala_B_c + pant__R_c + atp_c --> pnto__R_c + ppi_c + h_c + amp_c pa120_c + h2o_c --> pi_c + 12dgr120_c pa120_p + h2o_p --> 12dgr120_p + pi_p h2o_c + pa140_c --> 12dgr140_c + pi_c pa140_p + h2o_p --> 12dgr140_p + pi_p pa141_c + h2o_c --> pi_c + 12dgr141_c h2o_p + pa141_p --> 12dgr141_p + pi_p pa160_c + h2o_c --> pi_c + 12dgr160_c pa160_p + h2o_p --> 12dgr160_p + pi_p h2o_c + pa161_c --> pi_c + 12dgr161_c pa161_p + h2o_p --> 12dgr161_p + pi_p pa180_c + h2o_c --> 12dgr180_c + pi_c h2o_p + pa180_p --> 12dgr180_p + pi_p pa181_c + h2o_c --> pi_c + 12dgr181_c pa181_p + h2o_p --> pi_p + 12dgr181_p udcpp_c + ugmda_c --> ump_c + uagmda_c paps_c + trdrd_c --> trdox_c + so3_c + 2.0 h_c + pap_c paps_c + grxrd_c --> so3_c + grxox_c + 2.0 h_c + pap_c h2o_c + camp_c --> amp_c + h_c 35cgmp_c + h2o_c --> gmp_c + h_c pyr_c + coa_c + nad_c --> co2_c + nadh_c + accoa_c nad_c + pdx5p_c --> nadh_c + pydx5p_c + h_c o2_c + pdx5p_c --> h2o2_c + pydx5p_c phthr_c + nad_c + dxyl5p_c --> co2_c + pdx5p_c + h_c + nadh_c + pi_c + 2.0 h2o_c pdx5p_c + h2o_c --> pi_c + pydxn_c pe120_c + atp_c + h2o_c --> pe120_p + h_c + pi_c + adp_c pe140_c + atp_c + h2o_c --> pe140_p + h_c + pi_c + adp_c pe141_c + atp_c + h2o_c --> pe141_p + pi_c + h_c + adp_c pe160_c + atp_c + h2o_c --> h_c + pi_c + pe160_p + adp_c pe161_c + atp_c + h2o_c --> h_c + pe161_p + pi_c + adp_c pe180_c + atp_c + h2o_c --> pe180_p + h_c + pi_c + adp_c pe181_c + atp_c + h2o_c --> h_c + pi_c + adp_c + pe181_p h2o_p + peamn_p + o2_p --> pacald_p + nh4_p + h2o2_p peamn_e <=> peamn_p nad_c + 4per_c <=> nadh_c + ohpb_c + h_c pe161_p + lipa_p --> 12dgr161_p + enlipa_p lipa_p + pe181_p --> enlipa_p + 12dgr181_p f6p_c + atp_c --> fdp_c + adp_c + h_c tag6p__D_c + atp_c --> tagdp__D_c + adp_c + h_c s7p_c + atp_c --> adp_c + s17bp_c + h_c pyr_c + coa_c --> accoa_c + for_c pg120_c + atp_c + h2o_c --> pg120_p + h_c + pi_c + adp_c pg140_c + atp_c + h2o_c --> pg140_p + h_c + pi_c + adp_c pg141_c + atp_c + h2o_c --> h_c + pi_c + adp_c + pg141_p pg160_c + atp_c + h2o_c --> pg160_p + h_c + pi_c + adp_c pg161_c + h2o_c + atp_c --> h_c + pi_c + pg161_p + adp_c pg180_c + atp_c + h2o_c --> h_c + pi_c + adp_c + pg180_p pg181_c + atp_c + h2o_c --> h_c + pi_c + pg181_p + adp_c gam1p_c <=> gam6p_c nad_c + 3pg_c --> nadh_c + 3php_c + h_c g6p_c <=> f6p_c 3pg_c + atp_c <=> 13dpg_c + adp_c h2o_c + 6pgl_c --> 6pgc_c + h_c h2o_c + 2pglyc_c --> pi_c + glyclt_c 2pg_c <=> 3pg_c g1p_c <=> g6p_c pgp120_c + atp_c + h2o_c --> h_c + pi_c + adp_c + pgp120_p pgp140_c + atp_c + h2o_c --> h_c + pgp140_p + pi_c + adp_c pgp141_c + atp_c + h2o_c --> h_c + pi_c + pgp141_p + adp_c pgp160_c + atp_c + h2o_c --> h_c + pi_c + adp_c + pgp160_p pgp161_c + atp_c + h2o_c --> pgp161_p + h_c + pi_c + adp_c pgp180_c + atp_c + h2o_c --> pgp180_p + h_c + pi_c + adp_c pgp181_c + atp_c + h2o_c --> h_c + pgp181_p + pi_c + adp_c pgp120_c + h2o_c --> pg120_c + pi_c pgp120_p + h2o_p --> pg120_p + pi_p pgp140_c + h2o_c --> pi_c + pg140_c pgp140_p + h2o_p --> pg140_p + pi_p h2o_c + pgp141_c --> pg141_c + pi_c pgp141_p + h2o_p --> pi_p + pg141_p pgp160_c + h2o_c --> pg160_c + pi_c pgp160_p + h2o_p --> pg160_p + pi_p pgp161_c + h2o_c --> pi_c + pg161_c h2o_p + pgp161_p --> pg161_p + pi_p pgp180_c + h2o_c --> pi_c + pg180_c pgp180_p + h2o_p --> pi_p + pg180_p pgp181_c + h2o_c --> pg181_c + pi_c pgp181_p + h2o_p --> pi_p + pg181_p glyc3p_c + cdpdddecg_c --> pgp120_c + cmp_c + h_c cdpdtdecg_c + glyc3p_c --> pgp140_c + cmp_c + h_c glyc3p_c + cdpdtdec7eg_c --> h_c + cmp_c + pgp141_c glyc3p_c + cdpdhdecg_c --> pgp160_c + cmp_c + h_c glyc3p_c + cdpdhdec9eg_c --> pgp161_c + cmp_c + h_c cdpdodecg_c + glyc3p_c --> pgp180_c + cmp_c + h_c glyc3p_c + cdpdodec11eg_c --> pgp181_c + cmp_c + h_c pheme_c + atp_c + h2o_c --> h_c + pi_c + pheme_p + adp_c pheme_p --> pheme_e phe__L_c + akg_c <=> phpyr_c + glu__L_c phe__L_c + trnaphe_c + atp_c --> ppi_c + amp_c + phetrna_c h_p + phe__L_p <=> phe__L_c + h_c phe__L_e <=> phe__L_p minohp_p + 6.0 h2o_p --> 6.0 pi_p + inost_p h_p + pi_p <=> pi_c + h_c pi_e <=> pi_p pi_p + atp_c + h2o_c --> h_c + 2.0 pi_c + adp_c pa120_p + h2o_p --> ddca_p + 2ddecg3p_p pa140_p + h2o_p --> ttdca_p + 2tdecg3p_p h2o_p + pa141_p --> ttdcea_p + 2tdec7eg3p_p h2o_p + pa160_p --> 2hdecg3p_p + hdca_p pa161_p + h2o_p --> 2hdec9eg3p_p + hdcea_p h2o_p + pa180_p --> ocdca_p + 2odecg3p_p pa181_p + h2o_p --> 2odec11eg3p_p + ocdcea_p pe120_p + h2o_p --> ddca_p + h_p + 2agpe120_p h2o_p + pe140_p --> h_p + 2agpe140_p + ttdca_p h2o_p + pe141_p --> ttdcea_p + 2agpe141_p + h_p pe160_p + h2o_p --> hdca_p + h_p + 2agpe160_p pe161_p + h2o_p --> 2agpe161_p + h_p + hdcea_p pe180_p + h2o_p --> 2agpe180_p + h_p + ocdca_p pe181_p + h2o_p --> ocdcea_p + h_p + 2agpe181_p pg120_p + h2o_p --> ddca_p + 2agpg120_p + h_p pg140_p + h2o_p --> h_p + 2agpg140_p + ttdca_p h2o_p + pg141_p --> 2agpg141_p + ttdcea_p + h_p pg160_p + h2o_p --> hdca_p + h_p + 2agpg160_p pg161_p + h2o_p --> 2agpg161_p + h_p + hdcea_p pg180_p + h2o_p --> 2agpg180_p + h_p + ocdca_p h2o_p + pg181_p --> ocdcea_p + 2agpg181_p + h_p pa120_p + h2o_p --> ddca_p + h_p + 1ddecg3p_p pa140_p + h2o_p --> 1tdecg3p_p + h_p + ttdca_p h2o_p + pa141_p --> ttdcea_p + 1tdec7eg3p_p + h_p pa160_p + h2o_p --> hdca_p + 1hdecg3p_p + h_p pa161_p + h2o_p --> 1hdec9eg3p_p + h_p + hdcea_p pa180_p + h2o_p --> h_p + 1odecg3p_p + ocdca_p pa181_p + h2o_p --> 1odec11eg3p_p + h_p + ocdcea_p pe120_p + h2o_p --> ddca_p + h_p + 1agpe120_p h2o_p + pe140_p --> h_p + 1agpe140_p + ttdca_p h2o_p + pe141_p --> ttdcea_p + 1agpe141_p + h_p pe160_p + h2o_p --> hdca_p + h_p + 1agpe160_p pe161_p + h2o_p --> 1agpe161_p + h_p + hdcea_p pe180_p + h2o_p --> h_p + 1agpe180_p + ocdca_p pe181_p + h2o_p --> h_p + 1agpe181_p + ocdcea_p pg120_p + h2o_p --> ddca_p + 1agpg120_p + h_p pg140_p + h2o_p --> h_p + 1agpg140_p + ttdca_p pg141_p + h2o_p --> ttdcea_p + h_p + 1agpg141_p h2o_p + pg160_p --> h_p + hdca_p + 1agpg160_p pg161_p + h2o_p --> h_p + hdcea_p + 1agpg161_p pg180_p + h2o_p --> 1agpg180_p + h_p + ocdca_p h2o_p + pg181_p --> ocdcea_p + 1agpg181_p + h_p man1p_c <=> man6p_c 5aprbu_c + h2o_c --> 4r5au_c + pi_c pmeACP_c + h2o_c --> meoh_c + pimACP_c 4ampm_c + atp_c --> 2mahmp_c + adp_c pnto__R_c + atp_c --> adp_c + 4ppan_c + h_c pnto__R_p + na1_p --> pnto__R_c + na1_c pnto__R_e <=> pnto__R_p nadh_c + poaac_c --> 3amac_c + nad_c + h2o_c 2.0 flxso_c + pyr_c + coa_c <=> h_c + accoa_c + 2.0 flxr_c + co2_c h2o_c + pyr_c + q8_c --> co2_c + ac_c + q8h2_c h2o_c + ppi_c --> 2.0 pi_c + h_c pppi_c + h2o_c --> pi_c + ppi_c + h_c ppap_c + adp_c <=> ppa_c + atp_c ppal_e <=> ppal_p ppal_c <=> ppal_p ppa_p + na1_p --> ppa_c + na1_c ppa_e <=> ppa_p 2.0 5aop_c --> h_c + ppbng_c + 2.0 h2o_c pep_c + co2_c + h2o_c --> oaa_c + h_c + pi_c 4ppcys_c + h_c --> pan4p_c + co2_c oaa_c + atp_c --> co2_c + pep_c + adp_c ppcoa_c + succ_c --> ppa_c + succoa_c h2o_c + ppgpp_c --> gdp_c + ppi_c ppi_c + atp_c <=> pppi_c + adp_c pi_c + atp_c <=> ppi_c + adp_c r1p_c <=> r5p_c 2dr1p_c <=> 2dr5p_c 4ppan_c + ctp_c + cys__L_c --> cmp_c + ppi_c + h_c + 4ppcys_c nad_c + pphn_c --> 34hpp_c + nadh_c + co2_c pphn_c + h_c --> phpyr_c + co2_c + h2o_c pppg9_c + 1.5 o2_c --> ppp9_c + 3.0 h2o_c 3.0 fum_c + pppg9_c --> ppp9_c + 3.0 succ_c nadh_c + h_c + o2_c + pppn_c --> nad_c + cechddd_c pppn_p + h_p <=> pppn_c + h_c pppn_e <=> pppn_p pyr_c + atp_c + h2o_c --> 2.0 h_c + amp_c + pi_c + pep_c ppt_p + h2o_p --> h2_p + pi_p ppt_e <=> ppt_p pram_c + gly_c + atp_c <=> gar_c + h_c + pi_c + adp_c fpram_c + atp_c --> air_c + 2.0 h_c + pi_c + adp_c pran_c --> 2cpr5p_c prbamp_c + h2o_c --> prfp_c 5aizc_c + asp__L_c + atp_c --> h_c + pi_c + 25aics_c + adp_c h2o_c + prbatp_c --> h_c + ppi_c + prbamp_c fgam_c + atp_c + h2o_c + gln__L_c --> fpram_c + h_c + pi_c + glu__L_c + adp_c prfp_c <=> prlp_c pro__L_c + fad_c --> 1pyr5c_c + fadh2_c + h_c progly_p + atp_c + h2o_c --> h_c + pi_c + adp_c + progly_c progly_e <=> progly_p trnapro_c + pro__L_c + atp_c --> protrna_c + ppi_c + amp_c pro__L_p + atp_c + h2o_c --> h_c + pro__L_c + pi_c + adp_c h_p + pro__L_p <=> pro__L_c + h_c pro__L_p + na1_p --> pro__L_c + na1_c pro__L_e <=> pro__L_p r5p_c + atp_c <=> amp_c + prpp_c + h_c h_p + psclys_p --> psclys_c + h_c psclys_e <=> psclys_p pep_c + skm5p_c <=> 3psme_c + pi_c ps120_c + h_c --> co2_c + pe120_c ps140_c + h_c --> pe140_c + co2_c ps141_c + h_c --> co2_c + pe141_c ps160_c + h_c --> co2_c + pe160_c h_c + ps161_c --> co2_c + pe161_c ps180_c + h_c --> pe180_c + co2_c ps181_c + h_c --> co2_c + pe181_c glu__L_c + 3php_c --> akg_c + pser__L_c pser__L_e <=> pser__L_p pser__L_c + h2o_c --> pi_c + ser__L_c pser__L_p + h2o_p --> ser__L_p + pi_p ser__L_c + cdpdddecg_c --> ps120_c + cmp_c + h_c cdpdtdecg_c + ser__L_c --> ps140_c + cmp_c + h_c ser__L_c + cdpdtdec7eg_c --> h_c + ps141_c + cmp_c cdpdhdecg_c + ser__L_c --> ps160_c + cmp_c + h_c cdpdhdec9eg_c + ser__L_c --> cmp_c + ps161_c + h_c cdpdodecg_c + ser__L_c --> ps180_c + cmp_c + h_c ser__L_c + cdpdodec11eg_c --> ps181_c + cmp_c + h_c pi_c + ppcoa_c --> ppap_c + coa_c pi_c + accoa_c <=> coa_c + actp_c thrp_p + h2o_p --> pi_p + thr__L_p pan4p_c + atp_c + h_c --> dpcoa_c + ppi_c orn_c + ptrc_p <=> ptrc_c + orn_p akg_c + ptrc_c --> glu__L_c + 4abutn_c ptrc_p + atp_c + h2o_c --> ptrc_c + h_c + pi_c + adp_c h_p + ptrc_p --> ptrc_c + h_c ptrc_e <=> ptrc_p pi_c + adn_c <=> ade_c + r1p_c pi_c + dad_2_c <=> 2dr1p_c + ade_c gsn_c + pi_c <=> r1p_c + gua_c dgsn_c + pi_c <=> 2dr1p_c + gua_c pi_c + ins_c <=> hxan_c + r1p_c pi_c + din_c <=> hxan_c + 2dr1p_c pi_c + xtsn_c <=> xan_c + r1p_c pyam5p_c + o2_c + h2o_c --> pydx5p_c + h2o2_c + nh4_c pydam_c + atp_c --> pyam5p_c + adp_c + h_c pydam_e <=> pydam_p pydam_p --> pydam_c pydx_c + atp_c --> pydx5p_c + adp_c + h_c pydxn_c + atp_c --> h_c + pdx5p_c + adp_c pydxn_e <=> pydxn_p pydxn_p --> pydxn_c pydx5p_c + h2o_c --> pydx_c + pi_c pydx_e <=> pydx_p pydx_p --> pydx_c pep_c + adp_c + h_c --> pyr_c + atp_c pi_c + uri_c <=> ura_c + r1p_c ura_c + h_c + nadh_c + o2_c --> nad_c + uracp_c h_p + pyr_p <=> pyr_c + h_c pyr_e <=> pyr_p 2.0 o2_c + q8h2_c --> q8_c + 2.0 h_c + 2.0 o2s_c 2.0 o2_c + mql8_c --> mqn8_c + 2.0 o2s_c + 2.0 h_c quin_e <=> quin_p quin_p <=> quin_c quin_c + nad_c <=> 3dhq_c + 2.0 h_c + nadh_c dhap_c + iasp_c --> pi_c + quln_c + 2.0 h2o_c atp_c + r15bp_c --> adp_c + prpp_c r1p_c + atp_c --> r15bp_c + adp_c + h_c r5p_c + h2o_c --> rib__D_c + pi_c r5p_p + h2o_p --> rib__D_p + pi_p r5p_e <=> r5p_p ribflv_c + atp_c --> h_c + fmn_c + adp_c 4r5au_c + db4p_c --> pi_c + 2.0 h2o_c + dmlz_c 2.0 dmlz_c --> 4r5au_c + ribflv_c rib__D_c + atp_c --> adp_c + r5p_c + h_c rbl__L_c + atp_c --> adp_c + ru5p__L_c + h_c ru5p__L_c <=> xu5p__D_c rephaccoa_c <=> 2oxpaccoa_c rfamp_e <=> rfamp_p rfamp_p + h_p --> rfamp_e + h_c dtdprmn_c + kphphhlipa_c --> dtdp_c + icolipa_c + h_c rhcys_c --> dhptd_c + hcys__L_c rib__D_p + atp_c + h2o_c --> rib__D_c + pi_c + h_c + adp_c rib__D_e <=> rib__D_p rmn_c <=> rml_c rml_c + atp_c --> rml1p_c + adp_c + h_c rmn_e <=> rmn_p h_p + rmn_p --> rmn_c + h_c rml1p_c <=> dhap_c + lald__L_c trdrd_c + adp_c --> trdox_c + dadp_c + h2o_c grxrd_c + adp_c --> dadp_c + grxox_c + h2o_c trdrd_c + gdp_c --> trdox_c + dgdp_c + h2o_c grxrd_c + gdp_c --> h2o_c + grxox_c + dgdp_c trdrd_c + cdp_c --> trdox_c + h2o_c + dcdp_c grxrd_c + cdp_c --> h2o_c + grxox_c + dcdp_c trdrd_c + udp_c --> trdox_c + dudp_c + h2o_c grxrd_c + udp_c --> dudp_c + grxox_c + h2o_c 2.0 h_c + 2.0 flxr_c + atp_c --> 2.0 flxso_c + datp_c + h2o_c gtp_c + 2.0 h_c + 2.0 flxr_c --> 2.0 flxso_c + dgtp_c + h2o_c ctp_c + 2.0 flxr_c + 2.0 h_c --> 2.0 flxso_c + dctp_c + h2o_c utp_c + 2.0 h_c + 2.0 flxr_c --> 2.0 flxso_c + dutp_c + h2o_c ru5p__D_c <=> xu5p__D_c r5p_c <=> ru5p__D_c 5prdmbz_c + h2o_c --> pi_c + rdmbzi_c sufbcd_c + h2o_c + 2fe1s_c + sufsesh_c + atp_c --> sufbcd_2fe2s_c + 5.0 h_c + sufse_c + pi_c + adp_c 2.0 fe2_c + 2.0 sufsesh_c + atp_c + h2o_c + sufbcd_c + fadh2_c --> 2.0 sufse_c + 7.0 h_c + pi_c + sufbcd_2fe2s_c + fad_c + adp_c 2.0 sufsesh_c + 2.0 fe2_c + atp_c + h2o_c + sufbcd_2fe2s_c + fadh2_c --> 2.0 sufse_c + 7.0 h_c + pi_c + sufbcd_2fe2s2_c + fad_c + adp_c sufbcd_2fe2s_c + 4.0 h_c --> 2fe2s_c + sufbcd_c sufbcd_2fe2s2_c + fadh2_c + 2.0 h_c --> sufbcd_4fe4s_c + fad_c sufbcd_4fe4s_c + 4.0 h_c --> 4fe4s_c + sufbcd_c s7p_c --> gmhep7p_c 2.0 h_c + sucarg_c + 2.0 h2o_c --> co2_c + 2.0 nh4_c + sucorn_c gtp_c + so4_c + atp_c + h2o_c --> gdp_c + ppi_c + pi_c + aps_c sarcs_c + o2_c + h2o_c --> fald_c + h2o2_c + gly_c nad_c + sbt6p_c <=> nadh_c + f6p_c + h_c sbt__D_p + pep_c --> pyr_c + sbt6p_c sbt__D_e <=> sbt__D_p sufse_c + cys__L_c --> ala__L_c + sufsesh_c h2o_c + sl26da_c --> 26dap_LL_c + succ_c akg_c + sl26da_c <=> sl2a6o_c + glu__L_c sertrna_sec_c + selnp_c --> pi_c + sectrna_c + h_c 4.0 gthrd_c + 2.0 h_c + slnt_c --> gthox_c + dgslnt_c + 3.0 h2o_c dgslnt_c + h_c + nadph_c --> gthrd_c + nadp_c + gslnt_c nadph_c + gslnt_c --> gthrd_c + seln_c + nadp_c seln_c + atp_c + h2o_c --> selnp_c + pi_c + amp_c mql8_c + sel_c --> mqn8_c + slnt_c + h2o_c sel_e <=> sel_p sel_p + 2.0 h_p --> sel_c + 2.0 h_c ichor_c + akg_c + h_c --> co2_c + 2sephchc_c atp_c + ser__L_c + h_c <=> ppi_c + seramp_c accoa_c + ser__L_c <=> acser_c + coa_c ser__D_c --> pyr_c + nh4_c ser__L_c --> pyr_c + nh4_c ser__L_c + trnaser_c + atp_c --> ppi_c + sertrna_c + amp_c ser__L_c + trnasecys_c + atp_c --> ppi_c + sertrna_sec_c + amp_c ser__L_p + h_p <=> ser__L_c + h_c ser__L_p + na1_p --> na1_c + ser__L_c ser__L_e <=> ser__L_p Sfglutth_c + h2o_c --> gthrd_c + h_c + for_c sucglu_c + h2o_c --> glu__L_c + succ_c sucgsa_c + nad_c + h2o_c --> 2.0 h_c + sucglu_c + nadh_c 2sephchc_c --> pyr_c + 2shchc_c nad_c + dscl_c --> nadh_c + scl_c + h_c scl_c + fe2_c --> sheme_c + 3.0 h_c 3dhsk_c + h_c + nadph_c <=> nadp_c + skm_c skm_c + atp_c --> adp_c + skm5p_c + h_c suchms_c + cys__L_c --> cyst__L_c + succ_c + h_c skm_p + h_p --> skm_c + h_c skm_e <=> skm_p slnt_e <=> slnt_p slnt_p + h_p --> slnt_c + h_c so2_e <=> so2_p so2_p <=> so2_c so3_e <=> so3_p h_p + so4_p --> h_c + so4_c so4_e <=> so4_p sucorn_c + akg_c --> glu__L_c + sucgsa_c spmd_c + accoa_c --> N1aspmd_c + coa_c + h_c spmd_c + accoa_c --> n8aspmd_c + coa_c + h_c spmd_p + atp_c + h2o_c --> h_c + spmd_c + adp_c + pi_c spmd_c + h_p --> spmd_p + h_c spmd_e <=> spmd_p ametam_c + ptrc_c --> spmd_c + 5mta_c + h_c 2.0 o2s_c + 2.0 h_c --> h2o2_c + o2_c 2.0 h_p + 2.0 o2s_p --> h2o2_p + o2_p nad_c + sucsal_c + h2o_c --> nadh_c + succ_c + 2.0 h_c nadp_c + sucsal_c + h2o_c --> succ_c + 2.0 h_c + nadph_c asp__L_p + succ_c --> succ_p + asp__L_c sucbz_c + coa_c + atp_c --> ppi_c + sbzcoa_c + amp_c 2shchc_c --> sucbz_c + h2o_c succ_p + 2.0 h_p --> succ_c + 2.0 h_c succ_p + 3.0 h_p --> succ_c + 3.0 h_c h_p + succ_c --> succ_p + h_c succ_e <=> succ_p q8_c + succ_c --> fum_c + q8h2_c fum_p + succ_c --> fum_c + succ_p succ_c + mal__L_p --> mal__L_c + succ_p succ_c + coa_c + atp_c <=> succoa_c + pi_c + adp_c sucr_e <=> sucr_p tartr__D_p + succ_c --> succ_p + tartr__D_c pep_c + sucr_p --> suc6p_c + pyr_c sulfac_p + h2o_c + atp_c --> sulfac_c + h_c + pi_c + adp_c sulfac_e <=> sulfac_p so3_c + 5.0 h_c + 3.0 nadph_c --> h2s_c + 3.0 nadp_c + 3.0 h2o_c so4_p + atp_c + h2o_c --> so4_c + pi_c + h_c + adp_c tdec2eACP_c <=> cdec3eACP_c nad_c + altrn_c <=> h_c + nadh_c + tagur_c s7p_c + g3p_c <=> e4p_c + f6p_c tartr__L_c --> oaa_c + h2o_c tartr__D_e <=> tartr__D_p tartr__L_p + succ_c <=> succ_p + tartr__L_c tartr__L_e <=> tartr__L_p 3.0 h_p + tartr__D_p --> tartr__D_c + 3.0 h_c taur_c + akg_c + o2_c --> succ_c + co2_c + so3_c + h_c + aacald_c taur_p + atp_c + h2o_c --> taur_c + h_c + pi_c + adp_c taur_e <=> taur_p tcynt_e <=> tcynt_p h2o_c + thmpp_c --> pi_c + h_c + thmmp_c dtdp4addg_c + accoa_c --> dtdp4aaddg_c + coa_c + h_c dtdp4d6dg_c + glu__L_c --> dtdp4addg_c + akg_c dtdp4d6dg_c --> dtdp4d6dm_c dtdp4d6dm_c + nadph_c + h_c --> dtdprmn_c + nadp_c dtdpglu_c --> dtdp4d6dg_c + h2o_c lipidAds_c + atp_c --> h_c + adp_c + lipidA_c dsbdrd_c + dsbcox_p --> dsbcrd_p + dsbdox_c dsbdrd_c + dsbgox_p --> dsbgrd_p + dsbdox_c tagdp__D_c <=> dhap_c + g3p_c nadp_c + nadh_c + 2.0 h_p --> 2.0 h_c + nad_c + nadph_c thdp_c + succoa_c + h2o_c --> sl2a6o_c + coa_c methf_c + h2o_c --> 5fthf_c + h_c h2o2_c + trdrd_c --> trdox_c + 2.0 h2o_c thymd_p + h_p --> thymd_c + h_c thymd_p + h_p <=> thymd_c + h_c thymd_e <=> thymd_p h2o_c + atp_c + thm_p --> thm_c + h_c + pi_c + adp_c thm_e <=> thm_p athr__L_c --> gly_c + acald_c thr__L_c --> gly_c + acald_c nad_c + thr__L_c --> 2aobut_c + nadh_c + h_c thr__L_c --> 2obut_c + nh4_c thrp_e <=> thrp_p phom_c + h2o_c --> pi_c + thr__L_c trnathr_c + thr__L_c + atp_c --> ppi_c + thrtrna_c + amp_c thr__L_p + atp_c + h2o_c --> thr__L_c + h_c + pi_c + adp_c thr__L_c + h_p --> thr__L_p + h_c h_p + thr__L_p <=> thr__L_c + h_c thr__L_p + na1_p --> thr__L_c + na1_c thr__L_e <=> thr__L_p thym_c + h_p --> thym_p + h_c thym_e <=> thym_p nadph_c + dxyl5p_c + iscssh_c + atp_c + dhgly_c + h_c --> ppi_c + co2_c + amp_c + nadp_c + iscs_c + 2.0 h2o_c + 4mpetz_c xu5p__D_c + r5p_c <=> s7p_c + g3p_c xu5p__D_c + e4p_c <=> g3p_c + f6p_c tmao_c + h_c + mql8_c --> mqn8_c + h2o_c + tma_c tmao_p + mql8_c + h_p --> tma_p + h2o_p + mqn8_c tmao_c + h_c + 2dmmql8_c --> h2o_c + 2dmmq8_c + tma_c 2dmmql8_c + tmao_p + h_p --> tma_p + h2o_p + 2dmmq8_c tmao_e <=> tmao_p tma_e <=> tma_p thymd_c + atp_c --> adp_c + dtmp_c + h_c pi_c + thymd_c <=> 2dr1p_c + thym_c dump_c + mlthf_c --> dhf_c + dtmp_c thm_c + atp_c --> adp_c + thmmp_c + h_c thmmp_c + atp_c --> thmpp_c + adp_c 2mahmp_c + 4mpetz_c + h_c --> thmmp_c + ppi_c dhap_c <=> g3p_c dpcoa_c + atp_c --> 2tpr3dpcoa_c + ade_c trdox_c + nadph_c + h_c --> trdrd_c + nadp_c tre6p_c + h2o_c --> glc__D_c + g6p_c tre6p_c + h2o_c --> pi_c + tre_c g6p_c + udpg_c --> tre6p_c + udp_c + h_c h2o_c + tre_c --> 2.0 glc__D_c tre_p + h2o_p --> 2.0 glc__D_p tre_p + pep_c --> tre6p_c + pyr_c tre_e <=> tre_p trp__L_c + h2o_c <=> indole_c + pyr_c + nh4_c 3ig3p_c + ser__L_c --> g3p_c + trp__L_c + h2o_c indole_c + ser__L_c --> trp__L_c + h2o_c 3ig3p_c --> indole_c + g3p_c trp__L_c + trnatrp_c + atp_c --> trptrna_c + ppi_c + amp_c trp__L_p + h_p <=> trp__L_c + h_c trp__L_e <=> trp__L_p nadh_c + 2h3oppan_c + h_c <=> nad_c + glyc__R_c tsul_p + atp_c + h2o_c --> h_c + pi_c + adp_c + tsul_c tsul_e <=> tsul_p ttdca_e --> ttdca_p ttdcea_e --> ttdcea_p ttrcyc_e <=> ttrcyc_p h_p + ttrcyc_p --> ttrcyc_e + h_c tungs_p + atp_c + h2o_c --> h_c + tungs_c + pi_c + adp_c tungs_e <=> tungs_p tym_e <=> tym_p amet_c + nadph_c + tyr__L_c --> met__L_c + nadp_c + dhgly_c + 4crsol_c + dad_5_c + h_c tym_p + h2o_p + o2_p --> 4hoxpacd_p + nh4_p + h2o2_p h2o_p + tyrp_p --> tyr__L_p + pi_p tyrp_e <=> tyrp_p akg_c + tyr__L_c <=> 34hpp_c + glu__L_c trnatyr_c + tyr__L_c + atp_c --> tyrtrna_c + ppi_c + amp_c tyr__L_p + h_p <=> tyr__L_c + h_c tyr__L_e <=> tyr__L_p thmpp_c + adp_c + h_c --> pi_c + athtp_c u3hga_c + 3hmrsACP_c --> ACP_c + u23ga_c + h_c uamag_c + atp_c + 26dap__M_c --> ugmd_c + h_c + pi_c + adp_c h2o_p + udpacgal_p --> acgal1p_p + 2.0 h_p + ump_p uacgam_p + h2o_p --> acgam1p_p + 2.0 h_p + ump_p uacgam_e <=> uacgam_p 2.0 nad_c + uacmam_c + h2o_c --> 2.0 nadh_c + uacmamu_c + 3.0 h_c uacgam_c <=> uacmam_c 3hmrsACP_c + uacgam_c <=> u3aga_c + ACP_c pep_c + uacgam_c --> pi_c + uaccg_c acgam1p_c + utp_c + h_c --> uacgam_c + ppi_c uacgam_c + uagmda_c --> uaagmda_c + udp_c + h_c glu__D_c + uama_c + atp_c --> uamag_c + h_c + pi_c + adp_c ala__L_c + uamr_c + atp_c --> h_c + pi_c + uama_c + adp_c uaccg_c + nadph_c + h_c --> nadp_c + uamr_c udcpdp_c + h2o_c --> udcpp_c + pi_c + h_c frdp_c + 8.0 ipdp_c --> udcpdp_c + 8.0 ppi_c udcpdp_p + h2o_p --> pi_p + udcpp_p + h_p udcpp_p --> udcpp_c udpacgal_e <=> udpacgal_p udpg_c <=> udpgal_c udpgal_c --> udpgalfur_c udpgal_p + h2o_p --> 2.0 h_p + ump_p + gal1p_p udpgal_e <=> udpgal_p 2.0 nad_c + udpg_c + h2o_c --> 3.0 h_c + 2.0 nadh_c + udpglcur_c nad_c + udpglcur_c --> udpLa4o_c + nadh_c + co2_c udpglcur_e <=> udpglcur_p udpg_p + h2o_p --> g1p_p + 2.0 h_p + ump_p udpg_e <=> udpg_p udpLa4o_c + glu__L_c <=> udpLa4n_c + akg_c udpglcur_p + h2o_p --> glcur1p_p + 2.0 h_p + ump_p gal1p_c + udpg_c <=> g1p_c + udpgal_c 2.0 h_c + urdglyc_c + h2o_c --> co2_c + 2.0 nh4_c + glx_c ugmd_c + alaala_c + atp_c --> h_c + ugmda_c + pi_c + adp_c u3aga_c + h2o_c --> u3hga_c + ac_c 10fthf_c + udpLa4n_c --> udpLa4fn_c + thf_c + h_c uLa4n_c --> uLa4n_p uamr_c + LalaDgluMdap_c + atp_c --> ugmd_c + h_c + pi_c + adp_c h2o_c + um4p_c --> ugmd_c + ala__D_c uamr_c + LalaDgluMdapDala_c + atp_c --> um4p_c + h_c + pi_c + adp_c ump_c + atp_c <=> udp_c + adp_c ump_e <=> ump_p uLa4fn_c + h2o_c --> uLa4n_c + for_c udpLa4fn_c + udcpp_c --> udp_c + uLa4fn_c 2.0 amet_c + uppg3_c --> 2.0 ahcys_c + h_c + dscl_c hmbil_c --> h2o_c + uppg3_c uppg3_c + 4.0 h_c --> cpppg3_c + 4.0 co2_c ura_c + prpp_c --> ump_c + ppi_c uracp_c + h2o_c --> h_c + cbm_c + poaac_c ura_p + h_p --> ura_c + h_c ura_p + h_p <=> ura_c + h_c ura_e <=> ura_p urdglyc_c + nad_c --> nadh_c + oxur_c + h_c urea_e <=> urea_p urea_p <=> urea_c urate_c + o2_c + 2.0 h2o_c --> alltn_c + co2_c + h2o2_c uri_c + h2o_c --> rib__D_c + ura_c uri_c + gtp_c --> ump_c + gdp_c + h_c h_p + uri_p --> h_c + uri_c h_p + uri_p <=> h_c + uri_c uri_e <=> uri_p u23ga_c + h2o_c --> lipidX_c + ump_c + 2.0 h_c akg_c + val__L_c <=> 3mob_c + glu__L_c trnaval_c + atp_c + val__L_c --> ppi_c + amp_c + valtrna_c val__L_p + h2o_c + atp_c --> h_c + pi_c + adp_c + val__L_c h_p + val__L_p <=> h_c + val__L_c val__L_e <=> val__L_p ala__L_c + 3mob_c <=> pyr_c + val__L_c mptamp_c + 2.0 h_c + tungs_c --> wco_c + amp_c + cu2_c + h2o_c xu5p__L_c --> ru5p__L_c xan_c + nad_c + h2o_c --> nadh_c + h_c + urate_c h_p + xan_p --> xan_c + h_c xan_e <=> xan_p xan_p <=> xan_c xmp_e <=> xmp_p xan_c + prpp_c --> xmp_c + ppi_c xtsn_c + h2o_c --> xan_c + rib__D_c h_p + xtsn_p <=> h_c + xtsn_c xtsn_e <=> xtsn_p xyl__D_c <=> xylu__D_c glc__D_c <=> fru_c xylu__D_c + atp_c --> xu5p__D_c + adp_c + h_c xylu__L_c + atp_c --> xu5p__L_c + adp_c + h_c h_p + xylu__L_p --> xylu__L_c + h_c xylu__L_e <=> xylu__L_p xyl__D_p + atp_c + h2o_c --> xyl__D_c + pi_c + h_c + adp_c xyl__D_p + h_p --> h_c + xyl__D_c xyl__D_e <=> xyl__D_p h2o_c + zn2_c + atp_c --> adp_c + h_c + pi_c + zn2_p h_p + zn2_c --> h_c + zn2_p zn2_p --> zn2_c h2o_c + atp_c + zn2_p --> adp_c + h_c + pi_c + zn2_c zn2_e <=> zn2_p |
The model can be simulated by executing ~cameo.core.solver_based_model.SolverBasedModel.solve
.
solution = model.solve()
A quick overview of the solution can be obtained in form of a pandas DataFrame (all solution objects in cameo provide access to data frames through a data_frame
attribute).
solution
fluxes | reduced_costs | |
---|---|---|
DM_4crsol_c | 0.000219 | 0.000000e+00 |
DM_5drib_c | 0.000221 | -3.775930e-24 |
DM_aacald_c | 0.000000 | 0.000000e+00 |
DM_amob_c | 0.000002 | 4.867441e-23 |
... | ... | ... |
ZN2t3pp | 0.000000 | -2.073827e-03 |
ZN2tpp | 0.000335 | 0.000000e+00 |
ZNabcpp | 0.000000 | -8.295308e-03 |
Zn2tex | 0.000335 | 0.000000e+00 |
2583 rows × 2 columns
The data frame is accessible through solution.data_frame
.
solution.data_frame
fluxes | reduced_costs | |
---|---|---|
DM_4crsol_c | 0.000219 | 0.000000e+00 |
DM_5drib_c | 0.000221 | -3.775930e-24 |
DM_aacald_c | 0.000000 | 0.000000e+00 |
DM_amob_c | 0.000002 | 4.867441e-23 |
... | ... | ... |
ZN2t3pp | 0.000000 | -2.073827e-03 |
ZN2tpp | 0.000335 | 0.000000e+00 |
ZNabcpp | 0.000000 | -8.295308e-03 |
Zn2tex | 0.000335 | 0.000000e+00 |
2583 rows × 2 columns
Data frames make it very easy to process results. For example, let's take a look at reactions with flux != 0
solution.data_frame.query('fluxes != 0')
fluxes | reduced_costs | |
---|---|---|
DM_4crsol_c | 0.000219 | 0.000000e+00 |
DM_5drib_c | 0.000221 | -3.775930e-24 |
DM_amob_c | 0.000002 | 4.867441e-23 |
DM_mththf_c | 0.000440 | 0.000000e+00 |
... | ... | ... |
USHD | 0.019113 | 7.372575e-18 |
VALTA | -0.415702 | -0.000000e+00 |
ZN2tpp | 0.000335 | 0.000000e+00 |
Zn2tex | 0.000335 | 0.000000e+00 |
461 rows × 2 columns
Objects—models, reactions, metabolites, genes—can easily be explored in the Jupyter notebook, taking advantage of tab completion. For example, place your cursor after the period in model.reactions.
and press the TAB key. A dialog will appear that allows you to navigate the list of reactions encoded in the model.
model.reactions.PGK # delete PGK, place your cursor after the period and press the TAB key.
Id | PGK |
Name | Phosphoglycerate kinase |
Stoichiometry | 3pg_c + atp_c <=> 13dpg_c + adp_c |
Lower bound | -1000.000000 |
Upper bound | 1000.000000 |
For example, you can access the E4PD (Erythrose 4-phosphate dehydrogenase) reaction in the model.
model.reactions.E4PD
Id | E4PD |
Name | Erythrose 4-phosphate dehydrogenase |
Stoichiometry | e4p_c + nad_c + h2o_c <=> nadh_c + 2.0 h_c + 4per_c |
Lower bound | -1000.000000 |
Upper bound | 1000.000000 |
Be aware though that due variable naming restrictions in Python dot notation access to reactions (and other objects) might not work in some cases.
# model.reactions.12DGR120tipp # uncommenting and running this cell will produce a syntax error
In these cases you need to use the model.reactions.get_by_id
.
model.reactions.get_by_id('12DGR120tipp')
Id | 12DGR120tipp |
Name | 1,2 diacylglycerol transport via flipping (periplasm to cytoplasm, n-C12:0) |
Stoichiometry | 12dgr120_p --> 12dgr120_c |
Lower bound | 0.000000 |
Upper bound | 1000.000000 |
Metabolites are accessible through model.metabolites
. For example, D-glucose in the cytosolic compartment.
model.metabolites.glc__D_c
<Metabolite glc__D_c at 0x110493e80>
And it is easy to find the associated reactions
model.metabolites.glc__D_c.reactions
frozenset({<Reaction TRE6PH at 0x1105aac18>, <Reaction GLCATr at 0x110652048>, <Reaction G6PP at 0x110652080>, <Reaction GALS3 at 0x110652898>, <Reaction MLTG5 at 0x11060d0b8>, <Reaction MLTG3 at 0x11060d550>, <Reaction LACZ at 0x110623d68>, <Reaction MLTG4 at 0x11060d588>, <Reaction AMALT1 at 0x10f193dd8>, <Reaction TREH at 0x1105aa9e8>, <Reaction MLTG1 at 0x11060d5f8>, <Reaction MLTG2 at 0x11060d630>, <Reaction AMALT2 at 0x10f193e80>, <Reaction HEX1 at 0x110635ef0>, <Reaction AMALT3 at 0x10f193f28>, <Reaction AMALT4 at 0x10f193f60>, <Reaction GLCabcpp at 0x110643ba8>, <Reaction XYLI2 at 0x11059c7b8>, <Reaction GLCt2pp at 0x110643be0>})
A list of the genes encoded in the model can be accessed via model.genes
.
model.genes[0:10]
[<Gene b0241 at 0x11059c6d8>, <Gene b1377 at 0x11059c6a0>, <Gene b2215 at 0x11059c5f8>, <Gene b0929 at 0x11059c630>, <Gene b4035 at 0x11059c550>, <Gene b4033 at 0x11059c588>, <Gene b4034 at 0x11059c4e0>, <Gene b4032 at 0x11059c4a8>, <Gene b4036 at 0x11059c438>, <Gene b4213 at 0x11059c400>]
A few additional attributes have been added that are not available in a cobrapy model. For example, exchange reactions that allow certain metabolites to enter or leave the model can be accessed through model.exchanges
.
model.exchanges[0:10]
[<Reaction DM_4crsol_c at 0x109adde48>, <Reaction DM_5drib_c at 0x11020e2b0>, <Reaction DM_aacald_c at 0x10a959860>, <Reaction DM_amob_c at 0x10a959b70>, <Reaction DM_mththf_c at 0x10a961780>, <Reaction DM_oxam_c at 0x10a961828>, <Reaction EX_12ppd__R_e at 0x10fb1d860>, <Reaction EX_12ppd__S_e at 0x10fb1d940>, <Reaction EX_14glucan_e at 0x10fb1dd30>, <Reaction EX_15dap_e at 0x10fb1d978>]
Or, the current medium can be accessed through model.medium
.
model.medium
reaction_id | reaction_name | lower_bound | upper_bound | |
---|---|---|---|---|
0 | EX_ca2_e | Calcium exchange | -1000.00 | 1000.0 |
1 | EX_cbl1_e | Cob(I)alamin exchange | -0.01 | 1000.0 |
2 | EX_cl_e | Chloride exchange | -1000.00 | 1000.0 |
3 | EX_co2_e | CO2 exchange | -1000.00 | 1000.0 |
... | ... | ... | ... | ... |
21 | EX_slnt_e | Selenite exchange | -1000.00 | 1000.0 |
22 | EX_so4_e | Sulfate exchange | -1000.00 | 1000.0 |
23 | EX_tungs_e | Tungstate exchange | -1000.00 | 1000.0 |
24 | EX_zn2_e | Zinc exchange | -1000.00 | 1000.0 |
25 rows × 4 columns
It is also possible to get a list of essential reactions ...
model.essential_reactions()[0:10]
[<Reaction DM_4crsol_c at 0x109adde48>, <Reaction DM_5drib_c at 0x11020e2b0>, <Reaction DM_amob_c at 0x10a959b70>, <Reaction DM_mththf_c at 0x10a961780>, <Reaction BIOMASS_Ec_iJO1366_core_53p95M at 0x10fb1dcf8>, <Reaction EX_ca2_e at 0x10fb20ef0>, <Reaction EX_cl_e at 0x10fb250b8>, <Reaction EX_cobalt2_e at 0x10fb251d0>, <Reaction EX_cu2_e at 0x10fb25400>, <Reaction EX_glc__D_e at 0x10fb323c8>]
... and essential genes.
model.essential_genes()[0:10]
[<Gene b2311 at 0x11050c0b8>, <Gene b0907 at 0x11050c160>, <Gene b3608 at 0x110544198>, <Gene b0109 at 0x1105141d0>, <Gene b0180 at 0x11059c240>, <Gene b1281 at 0x11050c2b0>, <Gene b0639 at 0x1105142e8>, <Gene b0154 at 0x110544470>, <Gene b3939 at 0x1104ec4a8>, <Gene b3187 at 0x11050c5c0>]