cameo reuses and extends model data structures defined by cobrapy (COnstraints-Based Reconstruction and Analysis tool for Python). So, in addition to following this quick start guide and other cameo tutorials, we encourage you to explore cobrapy's documentation as well.
Loading a model is easy. Just import the ~cameo.io.load_model
function.
from cameo import load_model
For example, load the most current genome-scale metabolic reconstruction of Escherichia coli.
model = load_model("iJO1366")
Models, reactions, metabolites, etc., provide return HTML when evaluated in Jupyter notebooks and can thus be easily inspected.
model
Name | iJO1366 |
Number of metabolites | 1805 |
Number of reactions | 2583 |
Reactions | 4crsol_c --> 5drib_c --> aacald_c --> amob_c --> mththf_c --> oxam_c --> 0.000223 10fthf_c + 0.000223 2dmmql8_c + 2.5e-05 2fe2s_c + 0.000248 4fe4s_c + 0.000223 5mthf_c + 0.000279 accoa_c + 0.000223 adocbl_c + 0.499149 ala__L_c + 0.000223 amet_c + 0.28742 arg__L_c + 0.234232 asn__L_c + 0.234232 asp__L_c + 54.119975 atp_c + 0.000116 bmocogdp_c + 2e-06 btn_c + 0.004952 ca2_c + 0.000223 chor_c + 0.004952 cl_c + 0.002944 clpn160_p + 0.00229 clpn161_p + 0.00118 clpn181_p + 0.000168 coa_c + 2.4e-05 cobalt2_c + 0.008151 colipa_e + 0.129799 ctp_c + 0.000674 cu2_c + 0.088988 cys__L_c + 0.024805 datp_c + 0.025612 dctp_c + 0.025612 dgtp_c + 0.024805 dttp_c + 0.000223 enter_c + 0.000223 fad_c + 0.006388 fe2_c + 0.007428 fe3_c + 0.255712 gln__L_c + 0.255712 glu__L_c + 0.595297 gly_c + 0.154187 glycogen_c + 0.000223 gthrd_c + 0.209121 gtp_c + 48.752916 h2o_c + 0.000223 hemeO_c + 0.092056 his__L_c + 0.282306 ile__L_c + 0.18569 k_c + 0.437778 leu__L_c + 3e-06 lipopb_c + 0.333448 lys__L_c + 3.1e-05 malcoa_c + 0.149336 met__L_c + 0.008253 mg2_c + 0.000223 mlthf_c + 0.000658 mn2_c + 7e-06 mobd_c + 7e-06 mococdp_c + 7e-06 mocogdp_c + 0.000223 mql8_c + 0.001345 murein3p3p_p + 0.000605 murein3px4p_p + 0.005381 murein4p4p_p + 0.005448 murein4px4p_p + 0.000673 murein4px4px4p_p + 0.001787 nad_c + 4.5e-05 nadh_c + 0.000112 nadp_c + 0.000335 nadph_c + 0.012379 nh4_c + 0.000307 ni2_c + 0.012366 pe160_c + 0.031798 pe160_p + 0.009618 pe161_c + 0.024732 pe161_p + 0.004957 pe181_c + 0.012747 pe181_p + 0.005707 pg160_c + 0.004892 pg160_p + 0.004439 pg161_c + 0.003805 pg161_p + 0.002288 pg181_c + 0.001961 pg181_p + 0.180021 phe__L_c + 0.000223 pheme_c + 0.214798 pro__L_c + 0.03327 ptrc_c + 0.000223 pydx5p_c + 0.000223 q8h2_c + 0.000223 ribflv_c + 0.209684 ser__L_c + 0.000223 sheme_c + 0.004126 so4_c + 0.006744 spmd_c + 9.8e-05 succoa_c + 0.000223 thf_c + 0.000223 thmpp_c + 0.246506 thr__L_c + 0.055234 trp__L_c + 0.133993 tyr__L_c + 5.5e-05 udcpdp_c + 0.140101 utp_c + 0.411184 val__L_c + 0.000324 zn2_c --> 53.95 adp_c + 53.95 h_c + 53.945874 pi_c + 0.749831 ppi_c 0.000223 10fthf_c + 2.6e-05 2fe2s_c + 0.000223 2ohph_c + 0.00026 4fe4s_c + 0.513689 ala__L_c + 0.000223 amet_c + 0.295792 arg__L_c + 0.241055 asn__L_c + 0.241055 asp__L_c + 54.124831 atp_c + 0.000122 bmocogdp_c + 2e-06 btn_c + 0.005205 ca2_c + 0.005205 cl_c + 0.000576 coa_c + 2.5e-05 cobalt2_c + 0.133508 ctp_c + 0.000709 cu2_c + 0.09158 cys__L_c + 0.026166 datp_c + 0.027017 dctp_c + 0.027017 dgtp_c + 0.026166 dttp_c + 0.000223 fad_c + 0.006715 fe2_c + 0.007808 fe3_c + 0.26316 gln__L_c + 0.26316 glu__L_c + 0.612638 gly_c + 0.215096 gtp_c + 48.601527 h2o_c + 0.094738 his__L_c + 0.290529 ile__L_c + 0.195193 k_c + 0.019456 kdo2lipid4_e + 0.450531 leu__L_c + 0.343161 lys__L_c + 0.153686 met__L_c + 0.008675 mg2_c + 0.000223 mlthf_c + 0.000691 mn2_c + 7e-06 mobd_c + 0.013894 murein5px4p_p + 0.001831 nad_c + 0.000447 nadp_c + 0.013013 nh4_c + 0.000323 ni2_c + 0.017868 pe160_c + 0.045946 pe160_p + 0.054154 pe161_c + 0.02106 pe161_p + 0.185265 phe__L_c + 0.000223 pheme_c + 0.221055 pro__L_c + 0.000223 pydx5p_c + 0.000223 ribflv_c + 0.215792 ser__L_c + 0.000223 sheme_c + 0.004338 so4_c + 0.000223 thf_c + 0.000223 thmpp_c + 0.253687 thr__L_c + 0.056843 trp__L_c + 0.137896 tyr__L_c + 5.5e-05 udcpdp_c + 0.144104 utp_c + 0.423162 val__L_c + 0.000341 zn2_c --> 53.95 adp_c + 53.95 h_c + 53.945662 pi_c + 0.773903 ppi_c 12ppd__R_e --> 12ppd__S_e --> 14glucan_e --> 15dap_e --> 23camp_e --> 23ccmp_e --> 23cgmp_e --> 23cump_e --> 23dappa_e --> 26dap__M_e --> 2ddglcn_e --> 34dhpac_e --> 3amp_e --> 3cmp_e --> 3gmp_e --> 3hcinnm_e --> 3hpp_e --> 3hpppn_e --> 3ump_e --> 4abut_e --> 4hoxpacd_e --> 5dglcn_e --> 5mtr_e --> LalaDglu_e --> LalaDgluMdap_e --> LalaDgluMdapDala_e --> LalaLglu_e --> ac_e --> acac_e --> acald_e --> acgal_e --> acgal1p_e --> acgam_e --> acgam1p_e --> acmana_e --> acmum_e --> acnam_e --> acolipa_e --> acser_e --> ade_e --> adn_e --> adocbl_e --> ag_e --> agm_e --> akg_e --> ala_B_e --> ala__D_e --> ala__L_e --> alaala_e --> all__D_e --> alltn_e --> amp_e --> anhgm_e --> arab__L_e --> arbt_e --> arbtn_e --> arbtn_fe3_e --> arg__L_e --> ascb__L_e --> asn__L_e --> aso3_e --> asp__L_e --> btn_e --> but_e --> butso3_e --> ca2_e <=> cbi_e --> cbl1_e <=> cd2_e --> cgly_e --> chol_e --> chtbs_e --> cit_e --> cl_e <=> cm_e --> cmp_e --> co2_e <=> cobalt2_e <=> colipa_e --> colipap_e --> cpgn_e --> cpgn_un_e --> crn_e --> crn__D_e --> csn_e --> cu_e --> cu2_e <=> cyan_e --> cynt_e --> cys__D_e --> cys__L_e --> cytd_e --> dad_2_e --> damp_e --> dca_e --> dcmp_e --> dcyt_e --> ddca_e --> dgmp_e --> dgsn_e --> dha_e --> dimp_e --> din_e --> dms_e --> dmso_e --> dopa_e --> doxrbcn_e --> dtmp_e --> dump_e --> duri_e --> eca4colipa_e --> enlipa_e --> enter_e --> etha_e --> ethso3_e --> etoh_e --> f6p_e --> fald_e --> fe2_e <=> fe3_e <=> fe3dcit_e --> fe3dhbzs_e --> fe3hox_e --> fe3hox_un_e --> fecrm_e --> fecrm_un_e --> feenter_e --> feoxam_e --> feoxam_un_e --> for_e --> fru_e --> frulys_e --> fruur_e --> fuc__L_e --> fum_e --> fusa_e --> g1p_e --> g3pc_e --> g3pe_e --> g3pg_e --> g3pi_e --> g3ps_e --> g6p_e --> gal_e --> gal_bD_e --> gal1p_e --> galct__D_e --> galctn__D_e --> galctn__L_e --> galt_e --> galur_e --> gam_e --> gam6p_e --> gbbtn_e --> gdp_e --> glc__D_e <=> glcn_e --> glcr_e --> glcur_e --> glcur1p_e --> gln__L_e --> glu__L_e --> gly_e --> glyald_e --> glyb_e --> glyc_e --> glyc__R_e --> glyc2p_e --> glyc3p_e --> glyclt_e --> gmp_e --> gsn_e --> gthox_e --> gthrd_e --> gtp_e --> gua_e --> h_e <=> h2_e --> h2o_e <=> h2o2_e --> h2s_e --> hacolipa_e --> halipa_e --> hdca_e --> hdcea_e --> hg2_e --> his__L_e --> hom__L_e --> hxa_e --> hxan_e --> idon__L_e --> ile__L_e --> imp_e --> indole_e --> inost_e --> ins_e --> isetac_e --> k_e <=> kdo2lipid4_e --> lac__D_e --> lac__L_e --> lcts_e --> leu__L_e --> lipa_e --> lipa_cold_e --> lipoate_e --> lys__L_e --> lyx__L_e --> mal__D_e --> mal__L_e --> malt_e --> malthx_e --> maltpt_e --> malttr_e --> maltttr_e --> man_e --> man6p_e --> manglyc_e --> melib_e --> meoh_e --> met__D_e --> met__L_e --> metsox_R__L_e --> metsox_S__L_e --> mg2_e <=> mincyc_e --> minohp_e --> mmet_e --> mn2_e <=> mnl_e --> mobd_e <=> mso3_e --> n2o_e --> na1_e <=> nac_e --> nh4_e <=> ni2_e <=> nmn_e --> no_e --> no2_e --> no3_e --> novbcn_e --> o16a4colipa_e --> o2_e <=> o2s_e --> ocdca_e --> ocdcea_e --> octa_e --> orn_e --> orot_e --> pacald_e --> peamn_e --> phe__L_e --> pheme_e --> pi_e <=> pnto__R_e --> ppa_e --> ppal_e --> pppn_e --> ppt_e --> pro__L_e --> progly_e --> psclys_e --> pser__L_e --> ptrc_e --> pydam_e --> pydx_e --> pydxn_e --> pyr_e --> quin_e --> r5p_e --> rfamp_e --> rib__D_e --> rmn_e --> sbt__D_e --> sel_e <=> ser__D_e --> ser__L_e --> skm_e --> slnt_e <=> so2_e --> so3_e --> so4_e <=> spmd_e --> succ_e --> sucr_e --> sulfac_e --> tartr__D_e --> tartr__L_e --> taur_e --> tcynt_e --> thm_e --> thr__L_e --> thrp_e --> thym_e --> thymd_e --> tma_e --> tmao_e --> tre_e --> trp__L_e --> tsul_e --> ttdca_e --> ttdcea_e --> ttrcyc_e --> tungs_e <=> tym_e --> tyr__L_e --> tyrp_e --> uacgam_e --> udpacgal_e --> udpg_e --> udpgal_e --> udpglcur_e --> ump_e --> ura_e --> urea_e --> uri_e --> val__L_e --> xan_e --> xmp_e --> xtsn_e --> xyl__D_e --> xylu__L_e --> zn2_e <=> 12dgr120_p --> 12dgr120_c 12dgr140_p --> 12dgr140_c 12dgr141_p --> 12dgr141_c 12dgr160_p --> 12dgr160_c 12dgr161_p --> 12dgr161_c 12dgr180_p --> 12dgr180_c 12dgr181_p --> 12dgr181_c 12ppd__R_e <=> 12ppd__R_p 12ppd__R_p <=> 12ppd__R_c 12ppd__S_e <=> 12ppd__S_p 12ppd__S_p <=> 12ppd__S_c 14glucan_p + atp_c + h2o_c --> 14glucan_c + adp_c + h_c + pi_c 14glucan_e --> 14glucan_p 23camp_e <=> 23camp_p 23ccmp_e <=> 23ccmp_p 23cgmp_e <=> 23cgmp_p 23cump_e <=> 23cump_p 23dappa_p + h_p --> 23dappa_c + h_c 23dappa_e <=> 23dappa_p 23cump_p + h2o_p --> 3ump_p + h_p 23ccmp_p + h2o_p --> 3cmp_p + h_p 23camp_p + h2o_p --> 3amp_p + h_p 23cgmp_p + h2o_p --> 3gmp_p + h_p 26dap__M_e <=> 26dap__M_p 2ddecg3p_p --> 2ddecg3p_c 2tdecg3p_p --> 2tdecg3p_c 2tdec7eg3p_p --> 2tdec7eg3p_c 2hdecg3p_p --> 2hdecg3p_c 2hdec9eg3p_p --> 2hdec9eg3p_c 2odecg3p_p --> 2odecg3p_c 2odec11eg3p_p --> 2odec11eg3p_c 2agpe120_p --> 2agpe120_c 2agpe140_p --> 2agpe140_c 2agpe141_p --> 2agpe141_c 2agpe160_p --> 2agpe160_c 2agpe161_p --> 2agpe161_c 2agpe180_p --> 2agpe180_c 2agpe181_p --> 2agpe181_c 2agpe120_c + atp_c + ddca_c --> amp_c + pe120_c + ppi_c 2agpe140_c + atp_c + ttdca_c --> amp_c + pe140_c + ppi_c 2agpe141_c + atp_c + ttdcea_c --> amp_c + pe141_c + ppi_c 2agpe160_c + atp_c + hdca_c --> amp_c + pe160_c + ppi_c 2agpe161_c + atp_c + hdcea_c --> amp_c + pe161_c + ppi_c 2agpe180_c + atp_c + ocdca_c --> amp_c + pe180_c + ppi_c 2agpe181_c + atp_c + ocdcea_c --> amp_c + pe181_c + ppi_c 2agpg120_p --> 2agpg120_c 2agpg140_p --> 2agpg140_c 2agpg141_p --> 2agpg141_c 2agpg160_p --> 2agpg160_c 2agpg161_p --> 2agpg161_c 2agpg180_p --> 2agpg180_c 2agpg181_p --> 2agpg181_c 2agpg120_c + atp_c + ddca_c --> amp_c + pg120_c + ppi_c 2agpg140_c + atp_c + ttdca_c --> amp_c + pg140_c + ppi_c 2agpg141_c + atp_c + ttdcea_c --> amp_c + pg141_c + ppi_c 2agpg160_c + atp_c + hdca_c --> amp_c + pg160_c + ppi_c 2agpg161_c + atp_c + hdcea_c --> amp_c + pg161_c + ppi_c 2agpg180_c + atp_c + ocdca_c --> amp_c + pg180_c + ppi_c 2agpg181_c + atp_c + ocdcea_c --> amp_c + pg181_c + ppi_c 2dhguln_c + h_c + nadh_c --> glcn_c + nad_c 2dhguln_c + h_c + nadph_c --> glcn_c + nadp_c 2dhguln_c + h_c + nadh_c --> idon__L_c + nad_c 2dhguln_c + h_c + nadph_c --> idon__L_c + nadp_c 2mahmp_c + h2o_c --> 4ampm_c + h_c + pi_c 34dhpac_e <=> 34dhpac_p 3amac_c + h2o_c + h_c --> msa_c + nh4_c 3amp_e <=> 3amp_p 3cmp_e <=> 3cmp_p 3gmp_e <=> 3gmp_p 3hdecACP_c --> h2o_c + tdec2eACP_c 3hddecACP_c --> h2o_c + tddec2eACP_c 3hcddec5eACP_c --> h2o_c + t3c5ddeceACP_c 3hmrsACP_c --> h2o_c + tmrs2eACP_c 3hcmrs7eACP_c --> h2o_c + t3c7mrseACP_c 3hpalmACP_c --> h2o_c + tpalm2eACP_c 3hcpalm9eACP_c --> h2o_c + t3c9palmeACP_c 3hoctaACP_c --> h2o_c + toctd2eACP_c 3hcvac11eACP_c --> h2o_c + t3c11vaceACP_c 3haACP_c --> but2eACP_c + h2o_c 3hhexACP_c --> h2o_c + thex2eACP_c 3hoctACP_c --> h2o_c + toct2eACP_c 3hcinnm_c + h_c + nadh_c + o2_c --> dhcinnm_c + h2o_c + nad_c 3hpppn_c + h_c + nadh_c + o2_c --> dhpppn_c + h2o_c + nad_c 3hpp_e <=> 3hpp_p 3hpp_c + h_c --> 3hpp_p + h_p 3dhguln_c + atp_c --> 3dhgulnp_c + adp_c + h_c 3ump_p + h2o_p --> pi_p + uri_p 3cmp_p + h2o_p --> cytd_p + pi_p 3amp_p + h2o_p --> adn_p + pi_p 3gmp_p + h2o_p --> gsn_p + pi_p 3odecACP_c + h_c + nadph_c <=> 3hdecACP_c + nadp_c 3oddecACP_c + h_c + nadph_c <=> 3hddecACP_c + nadp_c 3ocddec5eACP_c + h_c + nadph_c --> 3hcddec5eACP_c + nadp_c 3omrsACP_c + h_c + nadph_c <=> 3hmrsACP_c + nadp_c 3ocmrs7eACP_c + h_c + nadph_c --> 3hcmrs7eACP_c + nadp_c 3opalmACP_c + h_c + nadph_c <=> 3hpalmACP_c + nadp_c 3ocpalm9eACP_c + h_c + nadph_c --> 3hcpalm9eACP_c + nadp_c 3ooctdACP_c + h_c + nadph_c <=> 3hoctaACP_c + nadp_c 3ocvac11eACP_c + h_c + nadph_c --> 3hcvac11eACP_c + nadp_c actACP_c + h_c + nadph_c <=> 3haACP_c + nadp_c 3ohexACP_c + h_c + nadph_c <=> 3hhexACP_c + nadp_c 3ooctACP_c + h_c + nadph_c <=> 3hoctACP_c + nadp_c h_c + malACP_c + ocACP_c --> 3odecACP_c + ACP_c + co2_c dcaACP_c + h_c + malACP_c --> 3oddecACP_c + ACP_c + co2_c cdec3eACP_c + h_c + malACP_c --> 3ocddec5eACP_c + ACP_c + co2_c ddcaACP_c + h_c + malACP_c --> 3omrsACP_c + ACP_c + co2_c cddec5eACP_c + h_c + malACP_c --> 3ocmrs7eACP_c + ACP_c + co2_c h_c + malACP_c + myrsACP_c --> 3opalmACP_c + ACP_c + co2_c h_c + malACP_c + tdeACP_c --> 3ocpalm9eACP_c + ACP_c + co2_c h_c + malACP_c + palmACP_c --> 3ooctdACP_c + ACP_c + co2_c h_c + hdeACP_c + malACP_c --> 3ocvac11eACP_c + ACP_c + co2_c butACP_c + h_c + malACP_c --> 3ohexACP_c + ACP_c + co2_c h_c + hexACP_c + malACP_c --> 3ooctACP_c + ACP_c + co2_c coa_c + oxadpcoa_c --> accoa_c + succoa_c LalaDgluMdap_p + atp_c + h2o_c --> LalaDgluMdap_c + adp_c + h_c + pi_c LalaDgluMdap_e <=> LalaDgluMdap_p 3ump_e <=> 3ump_p dopa_p + h2o_p + o2_p --> 34dhpac_p + h2o2_p + nh4_p 4hoxpacd_e <=> 4hoxpacd_p h2o_c + phthr_c --> 4hthr_c + pi_c LalaDgluMdapDala_c + h2o_c --> LalaDgluMdap_c + ala__D_c LalaDgluMdapDala_p + h2o_p --> LalaDgluMdap_p + ala__D_p LalaDgluMdapDala_p + atp_c + h2o_c --> LalaDgluMdapDala_c + adp_c + h_c + pi_c LalaDgluMdapDala_e <=> LalaDgluMdapDala_p 5dglcn_c + h_c + nadph_c <=> glcn_c + nadp_c 5dglcn_p + h_p <=> 5dglcn_c + h_c 5dglcn_e <=> 5dglcn_p dad_5_c + h2o_c --> 5drib_c + ade_c 5mtr_e <=> 5mtr_p 5mtr_c + h_c --> 5mtr_p + h_p ru5p__D_c <=> ara5p_c ACP_c + atp_c + ttdca_c --> amp_c + myrsACP_c + ppi_c ACP_c + atp_c + ttdcea_c --> amp_c + ppi_c + tdeACP_c ACP_c + atp_c + hdca_c --> amp_c + palmACP_c + ppi_c ACP_c + atp_c + hdcea_c --> amp_c + hdeACP_c + ppi_c ACP_c + atp_c + ocdcea_c --> amp_c + octeACP_c + ppi_c ACP_c + atp_c + ocdca_c --> amp_c + ocdcaACP_c + ppi_c ACP_c + atp_c + ddca_c --> amp_c + ddcaACP_c + ppi_c ACP_c + atp_c + dca_c --> amp_c + dcaACP_c + ppi_c ACP_c + atp_c + octa_c --> amp_c + ocACP_c + ppi_c aact_c + h2o_c + o2_c --> h2o2_c + mthgxl_c + nh4_c dtdp4aaddg_c + unagamu_c --> dtdp_c + h_c + unagamuf_c 14glucan_c --> malthx_c 14glucan_p --> malthx_p arbt6p_c + h2o_c --> g6p_c + hqn_c 4abut_c + akg_c --> glu__L_c + sucsal_c 4abutn_c + h2o_c + nad_c --> 4abut_c + 2.0 h_c + nadh_c 4abut_p + h_p --> 4abut_c + h_c 4abut_e <=> 4abut_p acac_c + accoa_c --> aacoa_c + ac_c 2.0 accoa_c <=> aacoa_c + coa_c accoa_c + btcoa_c <=> 3ohcoa_c + coa_c accoa_c + hxcoa_c <=> 3oocoa_c + coa_c accoa_c + occoa_c <=> 3odcoa_c + coa_c accoa_c + dcacoa_c <=> 3oddcoa_c + coa_c accoa_c + ddcacoa_c <=> 3otdcoa_c + coa_c accoa_c + tdcoa_c <=> 3ohdcoa_c + coa_c 3ohodcoa_c + coa_c <=> accoa_c + pmtcoa_c acac_p + h_p <=> acac_c + h_c acac_e <=> acac_p acald_c + coa_c + nad_c <=> accoa_c + h_c + nadh_c acald_e <=> acald_p acald_p <=> acald_c accoa_c + anth_c --> acanth_c + coa_c adocbip_c + gtp_c + h_c --> agdpcbi_c + ppi_c accoa_c + atp_c + hco3_c --> adp_c + h_c + malcoa_c + pi_c atp_c + coa_c + ppa_c --> adp_c + pi_c + ppcoa_c acgal1p_p + h2o_p --> acgal_p + pi_p acgal1p_e <=> acgal1p_p acgal_e <=> acgal_p acgam1p_p + h2o_p --> acgam_p + pi_p acgam1p_e <=> acgam1p_p acgam_c + atp_c --> acgam6p_c + adp_c + h_c uacgam_c + udcpp_c --> ump_c + unaga_c acgam_p + pep_c --> acgam6p_c + pyr_c acgam_e <=> acgam_p acglu_c + atp_c --> acg5p_c + adp_c accoa_c + glu__L_c --> acglu_c + coa_c + h_c 2obut_c + h_c + pyr_c --> 2ahbut_c + co2_c ac_c + atp_c <=> actp_c + adp_c h_c + 2.0 pyr_c --> alac__S_c + co2_c acmum6p_c + h2o_c --> acgam6p_c + lac__D_c uacmamu_c + unaga_c --> h_c + udp_c + unagamu_c acmana_p + pep_c --> acmanap_c + pyr_c acmana_e <=> acmana_p acmum_p + pep_c --> acmum6p_c + pyr_c acmum_e --> acmum_p acnam_p + h_p --> acnam_c + h_c acnam_e <=> acnam_p acnam_c --> acmana_c + pyr_c btcoa_c + fad_c <=> b2coa_c + fadh2_c fad_c + hxcoa_c <=> fadh2_c + hx2coa_c fad_c + occoa_c <=> fadh2_c + oc2coa_c dcacoa_c + fad_c <=> dc2coa_c + fadh2_c ddcacoa_c + fad_c <=> dd2coa_c + fadh2_c fad_c + tdcoa_c <=> fadh2_c + td2coa_c fad_c + pmtcoa_c <=> fadh2_c + hdd2coa_c fad_c + stcoa_c <=> fadh2_c + od2coa_c ACP_c + accoa_c <=> acACP_c + coa_c acorn_c + h2o_c --> ac_c + orn_c acolipa_p + atp_c + h2o_c --> acolipa_e + adp_c + h_c + pi_c acon_T_c <=> acon_C_c acon_T_c + amet_c --> aconm_c + ahcys_c cit_c <=> acon_C_c + h2o_c acon_C_c + h2o_c <=> icit_c acorn_c + akg_c <=> acg5sa_c + glu__L_c ddcaACP_c + h_c + pi_c --> ACP_c + ddcap_c h_c + myrsACP_c + pi_c --> ACP_c + ttdcap_c h_c + pi_c + tdeACP_c --> ACP_c + ttdceap_c h_c + palmACP_c + pi_c --> ACP_c + hdcap_c h_c + hdeACP_c + pi_c --> ACP_c + hdceap_c h_c + ocdcaACP_c + pi_c --> ACP_c + ocdcap_c h_c + octeACP_c + pi_c --> ACP_c + ocdceap_c apoACP_c + coa_c --> ACP_c + h_c + pap_c ac_c + atp_c + coa_c --> accoa_c + amp_c + ppi_c acser_e <=> acser_p acser_c --> acser_p ac_p + h_p <=> ac_c + h_c ac_p + na1_p --> ac_c + na1_c ac_e <=> ac_p adn_c + h2o_c + h_c --> ins_c + nh4_c 4adcho_c --> 4abz_c + h_c + pyr_c chor_c + gln__L_c --> 4adcho_c + glu__L_c ade_c + h2o_c + h_c --> hxan_c + nh4_c ade_p + h_p <=> ade_c + h_c ade_e <=> ade_p amp_c + atp_c <=> 2.0 adp_c amp_c + gtp_c <=> adp_c + gdp_c amp_c + itp_c <=> adp_c + idp_c amet_c + h_c --> ametam_c + co2_c atp_c --> camp_c + ppi_c adn_c + atp_c --> adp_c + amp_c + h_c adn_c + h2o_c --> ade_c + rib__D_c adn_p + h_p --> adn_c + h_c adn_p + h_p <=> adn_c + h_c adn_e <=> adn_p adocbi_c + atp_c --> adocbip_c + adp_c + h_c agdpcbi_c + rdmbzi_c --> adocbl_c + gmp_c + h_c adocbl_p + atp_c + h2o_c --> adocbl_c + adp_c + h_c + pi_c adocbl_e + h_p --> adocbl_p + h_c adprib_c + h2o_c --> amp_c + 2.0 h_c + r5p_c ade_c + prpp_c --> amp_c + ppi_c aps_c + atp_c --> adp_c + h_c + paps_c dcamp_c <=> amp_c + fum_c 25aics_c <=> aicar_c + fum_c asp__L_c + gtp_c + imp_c --> dcamp_c + gdp_c + 2.0 h_c + pi_c acgam6p_c + h2o_c --> ac_c + gam6p_c anhgm3p_c + h2o_c --> LalaDgluMdap_c + anhgm_c anhgm3p_p + h2o_p --> LalaDgluMdap_p + anhgm_p anhgm3p_c + h2o_c --> acgam_c + anhm3p_c anhgm3p_p + h_p --> anhgm3p_c + h_c anhgm4p_c + h2o_c --> LalaDgluMdapDala_c + anhgm_c anhgm4p_p + h2o_p --> LalaDgluMdapDala_p + anhgm_p anhgm4p_c + h2o_c --> ala__D_c + anhgm3p_c anhgm4p_p + h2o_p --> ala__D_p + anhgm3p_p anhgm4p_c + h2o_c --> acgam_c + anhm4p_c anhgm4p_p + h_p --> anhgm4p_c + h_c anhgm_c + h2o_c --> acgam_c + anhm_c adphep_DD_c --> adphep_LD_c agm_c + h2o_c --> ptrc_c + urea_c anhgm_p + h_p --> anhgm_c + h_c agm_e <=> agm_p 1ddecg3p_c + ddcaACP_c --> ACP_c + pa120_c 1tdecg3p_c + myrsACP_c --> ACP_c + pa140_c 1tdec7eg3p_c + tdeACP_c --> ACP_c + pa141_c 1hdecg3p_c + palmACP_c --> ACP_c + pa160_c 1hdec9eg3p_c + hdeACP_c --> ACP_c + pa161_c 1odecg3p_c + ocdcaACP_c --> ACP_c + pa180_c 1odec11eg3p_c + octeACP_c --> ACP_c + pa181_c acg5sa_c + nadp_c + pi_c <=> acg5p_c + h_c + nadph_c ag_c + h_e --> ag_e + h_c ahcys_c + h2o_c --> ade_c + rhcys_c 10fthf_c + aicar_c <=> fprica_c + thf_c air_c + atp_c + hco3_c --> 5caiz_c + adp_c + h_c + pi_c 5aizc_c <=> 5caiz_c akg_c + coa_c + nad_c --> co2_c + nadh_c + succoa_c akg_p + h_p <=> akg_c + h_c akg_e <=> akg_p alaala_c + h2o_c --> 2.0 ala__D_c alaala_p + atp_c + h2o_c --> adp_c + alaala_c + h_c + pi_c 2.0 ala__D_c + atp_c <=> adp_c + alaala_c + h_c + pi_c alaala_e <=> alaala_p LalaDglu_c <=> LalaLglu_c ala__L_c <=> ala__D_c ala__D_c + pydx5p_c --> pyam5p_c + pyr_c akg_c + ala__L_c <=> glu__L_c + pyr_c ala__L_c + pydx5p_c --> pyam5p_c + pyr_c ala__L_c + atp_c + trnaala_c --> alatrna_c + amp_c + ppi_c ala__L_p + atp_c + h2o_c --> adp_c + ala__L_c + h_c + pi_c ala__L_p + h_p --> ala__L_c + h_c ala__L_p + h_p <=> ala__L_c + h_c ala__L_p + na1_p --> ala__L_c + na1_c ala__L_e <=> ala__L_p glyald_c + h_c + nadh_c <=> glyc_c + nad_c etoh_c + nad_c <=> acald_c + h_c + nadh_c h2o_c + nad_c + pacald_c <=> 2.0 h_c + nadh_c + pac_c acald_c + h2o_c + nad_c --> ac_c + 2.0 h_c + nadh_c acald_c + h2o_c + nadp_c --> ac_c + 2.0 h_c + nadph_c h2o_c + nadp_c + ppal_c --> 2.0 h_c + nadph_c + ppa_c btal_c + h2o_c + nad_c --> but_c + 2.0 h_c + nadh_c all__D_c + atp_c --> adp_c + all6p_c + h_c all6p_c <=> allul6p_c alltt_c + 2.0 h2o_c + 2.0 h_c --> co2_c + 2.0 nh4_c + urdglyc_c alltn_c + h2o_c --> alltt_c + h_c alltn_p + h_p <=> alltn_c + h_c alltn_e <=> alltn_p allul6p_c <=> f6p_c all__D_p + atp_c + h2o_c --> adp_c + all__D_c + h_c + pi_c all__D_e <=> all__D_p alpp_p + pe160_p --> 2agpe160_p + lpp_p alpp_p + pg160_p --> 2agpg160_p + lpp_p h_c + mthgxl_c + nadph_c --> acetol_c + nadp_c acetol_c + h_c + nadh_c --> 12ppd__R_c + nad_c altrn_c --> 2ddglcn_c + h2o_c anhm3p_c + h2o_c --> LalaDgluMdap_c + anhm_c anhm4p_c + h2o_c --> LalaDgluMdapDala_c + anhm_c anhm4p_c + h2o_c --> ala__D_c + anhm3p_c malt_c + malttr_c --> glc__D_c + maltttr_c malt_c + maltttr_c --> glc__D_c + maltpt_c malt_c + maltpt_c --> glc__D_c + malthx_c malt_c + malthx_c --> glc__D_c + malthp_c acmanap_c <=> acgam6p_c acmana_c + atp_c --> acmanap_c + adp_c + h_c 8aonn_c + amet_c <=> amob_c + dann_c 2dmmql8_c + amet_c --> ahcys_c + h_c + mql8_c air_c + h2o_c + nad_c --> 4ampm_c + 2.0 for_c + 3.0 h_c + nadh_c amp_c + h2o_c --> ade_c + r5p_c cgly_c + h2o_c --> cys__L_c + gly_c h2o_c + progly_c --> gly_c + pro__L_c amp_e <=> amp_p anhgm_e <=> anhgm_p anhm_c + atp_c + h2o_c --> acmum6p_c + adp_c + h_c anth_c + prpp_c --> ppi_c + pran_c chor_c + gln__L_c --> anth_c + glu__L_c + h_c + pyr_c 2aobut_c + h_c --> aact_c + co2_c ala__L_c + pimACP_c --> 8aonn_c + ACP_c + co2_c ap4a_c + h2o_c --> 2.0 adp_c + 2.0 h_c 2.0 atp_c + h_c --> ap4a_c + ppi_c ap5a_c + h2o_c --> adp_c + atp_c + 2.0 h_c 15dap_c + ametam_c --> 5mta_c + h_c + na15dap_c ddcap_c + glyc3p_c --> 1ddecg3p_c + h_c + pi_c glyc3p_c + ttdcap_c --> 1tdecg3p_c + h_c + pi_c glyc3p_c + ttdceap_c --> 1tdec7eg3p_c + h_c + pi_c glyc3p_c + hdcap_c --> 1hdecg3p_c + h_c + pi_c glyc3p_c + hdceap_c --> 1hdec9eg3p_c + h_c + pi_c glyc3p_c + ocdcap_c --> 1odecg3p_c + h_c + pi_c glyc3p_c + ocdceap_c --> 1odec11eg3p_c + h_c + pi_c ddcap_c + h2o_c --> ddca_c + 2.0 h_c + pi_c h2o_c + ttdcap_c --> 2.0 h_c + pi_c + ttdca_c h2o_c + ttdceap_c --> 2.0 h_c + pi_c + ttdcea_c h2o_c + hdcap_c --> 2.0 h_c + hdca_c + pi_c h2o_c + hdceap_c --> 2.0 h_c + hdcea_c + pi_c h2o_c + ocdcap_c --> 2.0 h_c + ocdca_c + pi_c h2o_c + ocdceap_c --> 2.0 h_c + ocdcea_c + pi_c aact_c + h_c + nadh_c <=> appl_c + nad_c 5apru_c + h_c + nadph_c --> 5aprbu_c + nadp_c arab__L_c <=> rbl__L_c 2.0 arbtn_fe3_c + fadh2_c --> 2.0 arbtn_c + fad_c + 2.0 fe2_c + 2.0 h_c 2.0 arbtn_fe3_c + fmnh2_c --> 2.0 arbtn_c + 2.0 fe2_c + fmn_c + 2.0 h_c 2.0 arbtn_fe3_c + rbflvrd_c --> 2.0 arbtn_c + 2.0 fe2_c + 2.0 h_c + ribflv_c arbtn_fe3_p + atp_c + h2o_c --> adp_c + arbtn_fe3_c + h_c + pi_c arbtn_e + fe3_e --> arbtn_fe3_e arbtn_p + h_p --> arbtn_e + h_c arbtn_fe3_e + h_p --> arbtn_fe3_p + h_c arbtn_c + h_p --> arbtn_p + h_c arbt_p + pep_c --> arbt6p_c + pyr_c arbt_e --> arbt_p arab__L_p + atp_c + h2o_c --> adp_c + arab__L_c + h_c + pi_c arab__L_p + h_p <=> arab__L_c + h_c arab__L_c + h_p --> arab__L_p + h_c arab__L_e <=> arab__L_p agm_c + arg__L_p <=> agm_p + arg__L_c arg__L_c + h_c --> agm_c + co2_c arg__L_p + h_p --> agm_p + co2_p arg__L_p + orn_c <=> arg__L_c + orn_p argsuc_c <=> arg__L_c + fum_c asp__L_c + atp_c + citr__L_c --> amp_c + argsuc_c + h_c + ppi_c arg__L_c + atp_c + trnaarg_c --> amp_c + argtrna_c + ppi_c arg__L_p + atp_c + h2o_c --> adp_c + arg__L_c + h_c + pi_c arg__L_c + h_p --> arg__L_p + h_c arg__L_e <=> arg__L_p aspsa_c + nadp_c + pi_c <=> 4pasp_c + h_c + nadph_c ascb6p_c + h2o_c --> 3dhgulnp_c + h_c ascb__L_p + pep_c --> ascb6p_c + pyr_c ascb__L_e <=> ascb__L_p asn__L_c + h2o_c --> asp__L_c + nh4_c asn__L_p + h2o_p --> asp__L_p + nh4_p asp__L_c + atp_c + gln__L_c + h2o_c --> amp_c + asn__L_c + glu__L_c + h_c + ppi_c asp__L_c + atp_c + nh4_c --> amp_c + asn__L_c + h_c + ppi_c asn__L_c + atp_c + trnaasn_c --> amp_c + asntrna_c + ppi_c asn__L_p + atp_c + h2o_c --> adp_c + asn__L_c + h_c + pi_c asn__L_p + h_p <=> asn__L_c + h_c asn__L_e <=> asn__L_p aso3_c + atp_c + h2o_c --> adp_c + aso3_p + h_c + pi_c aso3_e <=> aso3_p asp__L_c + h_c --> ala_B_c + co2_c asp__L_c + cbp_c --> cbasp_c + h_c + pi_c asp__L_c + atp_c <=> 4pasp_c + adp_c asp__L_c + q8_c --> h_c + iasp_c + q8h2_c asp__L_c + mqn8_c --> h_c + iasp_c + mql8_c asp__L_c + fum_c --> h_c + iasp_c + succ_c asp__L_c + o2_c --> h2o2_c + h_c + iasp_c asp__L_c --> fum_c + nh4_c akg_c + asp__L_c <=> glu__L_c + oaa_c asp__L_c + atp_c + trnaasp_c --> amp_c + asptrna_c + ppi_c asp__L_p + atp_c + h2o_c --> adp_c + asp__L_c + h_c + pi_c asp__L_p + 2.0 h_p --> asp__L_c + 2.0 h_c asp__L_p + 3.0 h_p --> asp__L_c + 3.0 h_c asp__L_p + h_p --> asp__L_c + h_c asp__L_p + h_p <=> asp__L_c + h_c asp__L_e <=> asp__L_p aso4_c + 2.0 gthrd_c --> aso3_c + gthox_c + h2o_c arg__L_c + succoa_c --> coa_c + h_c + sucarg_c athr__L_c + nadp_c <=> 2aobut_c + h_c + nadph_c atp_c + h2o_c + h_c --> itp_c + nh4_c atp_c + h2o_c --> adp_c + h_c + pi_c atp_c + prpp_c --> ppi_c + prbatp_c adp_c + 4.0 h_p + pi_c <=> atp_c + h2o_c + 3.0 h_c ala_B_p + h_p --> ala_B_c + h_c ala_B_e <=> ala_B_p betald_c + h2o_c + nad_c --> glyb_c + 2.0 h_c + nadh_c betald_c + h2o_c + nadp_c --> glyb_c + 2.0 h_c + nadph_c moco_c + mptamp_c --> amp_c + bmoco_c + cu2_c bmoco_c + gtp_c + h_c --> bmoco1gdp_c + ppi_c bmoco1gdp_c + gtp_c + h_c --> bmocogdp_c + ppi_c h2o_c + pap_c --> amp_c + pi_c btnso_c + h_c + nadh_c --> btn_c + h2o_c + nad_c btnso_c + h_c + nadph_c --> btn_c + h2o_c + nadp_c btn_p + h_p --> btn_c + h_c btn_e <=> btn_p 2fe2s_c + amet_c + dtbt_c --> 2fe1s_c + btn_c + dad_5_c + h_c + met__L_c accoa_c + but_c --> ac_c + btcoa_c atp_c + butso3_p + h2o_c --> adp_c + butso3_c + h_c + pi_c butso3_e <=> butso3_p but_p + h_p <=> but_c + h_c but_e <=> but_p bwco_c + gtp_c + h_c --> bwco1gdp_c + ppi_c bwco1gdp_c + gtp_c + h_c --> bwcogdp_c + ppi_c mptamp_c + wco_c --> amp_c + bwco_c + cu2_c ca2_c + h_p --> ca2_p + h_c ca2_e <=> ca2_p 15dap_c + h_p + lys__L_p --> 15dap_p + h_c + lys__L_c 2.0 h2o2_c --> 2.0 h2o_c + o2_c ca2_c + na1_p <=> ca2_p + na1_c atp_c + cbi_c + h_c <=> adocbi_c + pppi_c cbi_e + h_p --> cbi_p + h_c atp_c + cbi_p + h2o_c --> adp_c + cbi_c + h_c + pi_c atp_c + cbl1_p + h2o_c --> adp_c + cbl1_c + h_c + pi_c cbl1_e + h_p --> cbl1_p + h_c atp_c + cbl1_c + h_c <=> adocbl_c + pppi_c cbm_c + 2.0 h_c --> co2_c + nh4_c atp_c + co2_c + nh4_c <=> adp_c + cbp_c + 2.0 h_c 2.0 atp_c + gln__L_c + h2o_c + hco3_c --> 2.0 adp_c + cbp_c + glu__L_c + 2.0 h_c + pi_c atp_c + cdg_c + nh4_c --> adp_c + h2o_c + h_c + pi_c + preq0_c atp_c + cd2_c + h2o_c --> adp_c + cd2_p + h_c + pi_c cd2_c + h_p --> cd2_p + h_c cd2_e <=> cd2_p cd2_p --> cd2_c cdpdddecg_c + h2o_c --> cmp_c + 2.0 h_c + pa120_c cdpdtdecg_c + h2o_c --> cmp_c + 2.0 h_c + pa140_c cdpdtdec7eg_c + h2o_c --> cmp_c + 2.0 h_c + pa141_c cdpdhdecg_c + h2o_c --> cmp_c + 2.0 h_c + pa160_c cdpdhdec9eg_c + h2o_c --> cmp_c + 2.0 h_c + pa161_c cdpdodecg_c + h2o_c --> cmp_c + 2.0 h_c + pa180_c cdpdodec11eg_c + h2o_c --> cmp_c + 2.0 h_c + pa181_c 3.0 h_c + 2.0 nadph_c + preq0_c --> 2.0 nadp_c + preq1_c cph4_c + h_c --> cdg_c + nh4_c 4c2me_c + atp_c --> 2p4c2me_c + adp_c + h_c 2.0 amet_c + pe161_c --> 2.0 ahcys_c + cpe160_c + 2.0 h_c 2.0 amet_c + pg161_c --> 2.0 ahcys_c + cpg160_c + 2.0 h_c 2.0 amet_c + pe181_c --> 2.0 ahcys_c + cpe180_c + 2.0 h_c 2.0 amet_c + pg181_c --> 2.0 ahcys_c + cpg180_c + 2.0 h_c atp_c + cgly_p + h2o_c --> adp_c + cgly_c + h_c + pi_c cgly_e <=> cgly_p atp_c + chol_p + h2o_c --> adp_c + chol_c + h_c + pi_c chol_p + h_p --> chol_c + h_c chol_e <=> chol_p chol_c + nad_c --> betald_c + h_c + nadh_c chor_c --> pphn_c 3psme_c --> chor_c + pi_c chor_c --> 4hbz_c + pyr_c chtbs_p + pep_c --> chtbs6p_c + pyr_c chtbs_e <=> chtbs_p cinnm_c + h_c + nadh_c + o2_c --> cenchddd_c + nad_c cit_c --> ac_c + oaa_c cit_c + h_p --> cit_p + h_c cit_p + succ_c --> cit_c + succ_p cit_e <=> cit_p atp_c + h2o_c + lipa_cold_p --> adp_c + h_c + lipa_cold_e + pi_c clpn120_p + h2o_p --> h_p + pa120_p + pg120_p clpn140_p + h2o_p --> h_p + pa140_p + pg140_p clpn141_p + h2o_p --> h_p + pa141_p + pg141_p clpn160_p + h2o_p --> h_p + pa160_p + pg160_p clpn161_p + h2o_p --> h_p + pa161_p + pg161_p clpn180_p + h2o_p --> h_p + pa180_p + pg180_p clpn181_p + h2o_p --> h_p + pa181_p + pg181_p 2.0 pg120_p <=> clpn120_p + glyc_p 2.0 pg140_p <=> clpn140_p + glyc_p 2.0 pg141_p <=> clpn141_p + glyc_p 2.0 pg160_p <=> clpn160_p + glyc_p 2.0 pg161_p <=> clpn161_p + glyc_p 2.0 pg180_p <=> clpn180_p + glyc_p 2.0 pg181_p <=> clpn181_p + glyc_p 2.0 cl_p + h_c --> 2.0 cl_c + h_p cl_e <=> cl_p cmp_c + h2o_c --> csn_c + r5p_c cmp_e <=> cmp_p cm_e <=> cm_p cm_p + h_p --> cm_e + h_c co2_e <=> co2_p co2_p <=> co2_c atp_c + cobalt2_c + h2o_c --> adp_c + cobalt2_p + h_c + pi_c cobalt2_c + h_p --> cobalt2_p + h_c cobalt2_e <=> cobalt2_p cobalt2_p --> cobalt2_c colipa_p + udcpdp_p --> colipap_p + udcpp_p atp_c + colipap_p + h2o_c --> adp_c + colipap_e + h_c + pi_c atp_c + colipa_c + h2o_c --> adp_c + colipa_p + h_c + pi_c atp_c + colipa_p + h2o_c --> adp_c + colipa_e + h_c + pi_c 2.0 cpgn_c + fadh2_c --> 2.0 cpgn_un_c + fad_c + 2.0 fe2_c + 2.0 h_c 2.0 cpgn_c + fmnh2_c --> 2.0 cpgn_un_c + 2.0 fe2_c + fmn_c + 2.0 h_c 2.0 cpgn_c + rbflvrd_c --> 2.0 cpgn_un_c + 2.0 fe2_c + 2.0 h_c + ribflv_c cpgn_un_p + h_p --> cpgn_un_e + h_c cpgn_un_c + h_p --> cpgn_un_p + h_c atp_c + cpgn_p + h2o_c --> adp_c + cpgn_c + h_c + pi_c cpgn_un_e + fe3_e --> cpgn_e cpgn_e + h_p --> cpgn_p + h_c ahdt_c + h2o_c --> acald_c + cph4_c + h_c + pppi_c gtp_c + h2o_c --> cpmp_c + ppi_c cpppg3_c + 2.0 h_c + o2_c --> 2.0 co2_c + 2.0 h2o_c + pppg9_c 2.0 amet_c + cpppg3_c --> 2.0 co2_c + 2.0 dad_5_c + 2.0 met__L_c + pppg9_c bbtcoa_c + crn_c <=> crncoa_c + gbbtn_c atp_c + coa_c + crn_c --> adp_c + crncoa_c + pi_c crncoa_c <=> crnDcoa_c crn_c + ctbtcoa_c <=> crncoa_c + ctbt_c crncoa_c <=> ctbtcoa_c + h2o_c atp_c + coa_c + crn__D_c --> adp_c + crnDcoa_c + pi_c atp_c + crn__D_p + h2o_c --> adp_c + crn__D_c + h_c + pi_c crn__D_p + h_p <=> crn__D_c + h_c crn__D_e <=> crn__D_p atp_c + crn_p + h2o_c --> adp_c + crn_c + h_c + pi_c crn_p + h_p <=> crn_c + h_c crn_p + gbbtn_c --> crn_c + gbbtn_p crn__D_c + crn_p --> crn__D_p + crn_c crn_e <=> crn_p accoa_c + h2o_c + oaa_c --> cit_c + coa_c + h_c csn_c + h2o_c + h_c --> nh4_c + ura_c csn_p + h_p --> csn_c + h_c csn_e <=> csn_p atp_c + coa_c + ctbt_c --> adp_c + ctbtcoa_c + pi_c atp_c + ctbt_p + h2o_c --> adp_c + ctbt_c + h_c + pi_c ctbt_p + h_p <=> ctbt_c + h_c tdecoa_c <=> td2coa_c hdcoa_c <=> hdd2coa_c odecoa_c <=> od2coa_c atp_c + gln__L_c + h2o_c + utp_c --> adp_c + ctp_c + glu__L_c + 2.0 h_c + pi_c 4.0 cu_p + 4.0 h_p + o2_p --> 4.0 cu2_p + 2.0 h2o_p atp_c + cu_c + h2o_c --> adp_c + cu_p + h_c + pi_c atp_c + cu2_c + h2o_c --> adp_c + cu2_p + h_c + pi_c cu2_e <=> cu2_p cu2_p --> cu2_c cu_c + h_e --> cu_e + h_c cu_e <=> cu_p cyan_c + tsul_c --> h_c + so3_c + tcynt_c cyan_p + tsul_p --> h_p + so3_p + tcynt_p cyan_e <=> cyan_p cynt_c + 3.0 h_c + hco3_c --> 2.0 co2_c + nh4_c cynt_p + h_p --> cynt_c + h_c cynt_e <=> cynt_p cys__D_c + h2o_c --> h2s_c + nh4_c + pyr_c cys__L_c + h2o_c --> h2s_c + nh4_c + pyr_c atp_c + cys__D_p + h2o_c --> adp_c + cys__D_c + h_c + pi_c cys__D_e <=> cys__D_p acser_c + h2s_c --> ac_c + cys__L_c + h_c 3sala_c + 2.0 h_c --> ala__L_c + so2_c cyst__L_c + h2o_c --> hcys__L_c + nh4_c + pyr_c atp_c + cys__L_c + trnacys_c --> amp_c + cystrna_c + ppi_c atp_c + cys__L_c + h2o_c --> adp_c + cys__L_p + h_c + pi_c atp_c + cys__L_p + h2o_c --> adp_c + cys__L_c + h_c + pi_c cys__L_e <=> cys__L_p cys__L_c --> cys__L_p 2.0 h_c + mql8_c + 0.5 o2_c --> h2o_c + 2.0 h_p + mqn8_c 2.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 2.0 h_p + q8_c 4.0 h_c + 0.5 o2_c + q8h2_c --> h2o_c + 4.0 h_p + q8_c cytd_c + h2o_c + h_c --> nh4_c + uri_c cytd_c + h2o_c --> csn_c + rib__D_c cytd_c + gtp_c --> cmp_c + gdp_c + h_c cytd_p + h_p --> cytd_c + h_c cytd_p + h_p <=> cytd_c + h_c cytd_e <=> cytd_p atp_c + cmp_c <=> adp_c + cdp_c atp_c + dcmp_c <=> adp_c + dcdp_c h_p + lac__D_p <=> h_c + lac__D_c lac__D_e <=> lac__D_p ala__D_c + fad_c + h2o_c --> fadh2_c + nh4_c + pyr_c dad_2_c + h2o_c + h_c --> din_c + nh4_c atp_c + damp_c <=> adp_c + dadp_c dad_2_p + h_p --> dad_2_c + h_c dad_2_e <=> dad_2_p 12dgr120_c + atp_c --> adp_c + h_c + pa120_c 12dgr140_c + atp_c --> adp_c + h_c + pa140_c 12dgr141_c + atp_c --> adp_c + h_c + pa141_c 12dgr160_c + atp_c --> adp_c + h_c + pa160_c 12dgr161_c + atp_c --> adp_c + h_c + pa161_c 12dgr180_c + atp_c --> adp_c + h_c + pa180_c 12dgr181_c + atp_c --> adp_c + h_c + pa181_c ala__D_p + h_p --> ala__D_c + h_c ala__D_e <=> ala__D_p damp_e <=> damp_p 23dappa_c + h2o_c --> 2.0 nh4_c + pyr_c 26dap__M_c + h_c --> co2_c + lys__L_c 26dap_LL_c <=> 26dap__M_c 26dap__M_p + atp_c + h2o_c --> 26dap__M_c + adp_c + h_c + pi_c 15dap_e <=> 15dap_p ctp_c + h_c + pa120_c --> cdpdddecg_c + ppi_c ctp_c + h_c + pa140_c --> cdpdtdecg_c + ppi_c ctp_c + h_c + pa141_c --> cdpdtdec7eg_c + ppi_c ctp_c + h_c + pa160_c --> cdpdhdecg_c + ppi_c ctp_c + h_c + pa161_c --> cdpdhdec9eg_c + ppi_c ctp_c + h_c + pa180_c --> cdpdodecg_c + ppi_c ctp_c + h_c + pa181_c --> cdpdodec11eg_c + ppi_c datp_c + h2o_c + h_c --> ditp_c + nh4_c ru5p__D_c --> db4p_c + for_c + h_c atp_c + co2_c + dann_c --> adp_c + dtbt_c + 3.0 h_c + pi_c chtbs6p_c + h2o_c --> acgam6p_c + acgam_c dca_e <=> dca_p dcmp_e <=> dcmp_p dctp_c + h2o_c + h_c --> dutp_c + nh4_c dcyt_c + h2o_c + h_c --> duri_c + nh4_c dcyt_p + h_p --> dcyt_c + h_c dcyt_e <=> dcyt_p ddca_e --> ddca_p 2dh3dgal_c + atp_c --> 2dh3dgal6p_c + adp_c + h_c 2ddglcn_p + h_p <=> 2ddglcn_c + h_c 2ddglcn_e <=> 2ddglcn_p 2ddglcn_c + atp_c --> 2ddg6p_c + adp_c + h_c e4p_c + h2o_c + pep_c --> 2dda7p_c + pi_c 2dh3dgal6p_c <=> g3p_c + pyr_c atp_c + dgmp_c <=> adp_c + dgdp_c dgmp_e <=> dgmp_p dgsn_p + h_p --> dgsn_c + h_c dgsn_e <=> dgsn_p 23dhacoa_c + h2o_c <=> 3hadpcoa_c 23dhmb_c --> 3mob_c + h2o_c 23dhmp_c --> 3mop_c + h2o_c dha_c + pep_c --> dhap_c + pyr_c dha_e <=> dha_p dha_p <=> dha_c 23ddhb_c + nad_c <=> 23dhb_c + h_c + nadh_c 23dhb_c + atp_c + h_c --> 23dhba_c + ppi_c 23dhbzs_c + h2o_c --> 23dhb_c + ser__L_c cenchddd_c + nad_c --> dhcinnm_c + h_c + nadh_c dhcinnm_c + o2_c --> h_c + hkntd_c 23dhdp_c + h_c + nadph_c --> nadp_c + thdp_c aspsa_c + pyr_c --> 23dhdp_c + 2.0 h2o_c + h_c dhf_c + h_c + nadph_c <=> nadp_c + thf_c atp_c + dhpt_c + glu__L_c --> adp_c + dhf_c + h_c + pi_c dhmpt_c + h_c + nadph_c --> nadp_c + thmnp_c dhna_c + h_c + octdp_c --> 2dmmql8_c + co2_c + ppi_c h_c + sbzcoa_c --> 14dhncoa_c + h2o_c 14dhncoa_c + h2o_c --> coa_c + dhna_c + h_c dhnpt_c <=> 6hmhpt_c + gcald_c dhnpt_c <=> dhmpt_c dhor__S_c + q8_c --> orot_c + q8h2_c dhor__S_c + mqn8_c --> mql8_c + orot_c dhor__S_c + fum_c --> orot_c + succ_c dhor__S_c + h2o_c <=> cbasp_c + h_c cechddd_c + nad_c --> dhpppn_c + h_c + nadh_c 25drapp_c + h2o_c + h_c --> 5apru_c + nh4_c 4abz_c + 6hmhptpp_c --> dhpt_c + ppi_c dhptd_c --> mdhdhf_c dhptdn_c + 3.0 h_c + nadph_c --> nadp_c + thptdn_c dhptdn_c + 3.0 h_c + nadh_c --> nad_c + thptdn_c ahdt_c <=> dhmptp_c 2dda7p_c --> 3dhq_c + pi_c 3dhq_c --> 3dhsk_c + h2o_c dimp_e <=> dimp_p din_p + h_p --> din_c + h_c din_e <=> din_p 25dkglcn_c + h_c + nadph_c --> 2dhguln_c + nadp_c 25dkglcn_c + h_c + nadh_c --> 5dglcn_c + nad_c 25dkglcn_c + h_c + nadph_c --> 5dglcn_c + nadp_c dmpp_c + ipdp_c --> grdp_c + ppi_c h2mb4p_c + h_c + nadh_c --> dmpp_c + h2o_c + nad_c 2omhmbl_c + amet_c --> ahcys_c + h_c + q8h2_c dmso_c + mql8_c --> dms_c + h2o_c + mqn8_c dmso_p + mql8_c --> dms_p + h2o_p + mqn8_c 2dmmql8_c + dmso_c --> 2dmmq8_c + dms_c + h2o_c 2dmmql8_c + dmso_p --> 2dmmq8_c + dms_p + h2o_p dmso_e <=> dmso_p dmso_p <=> dmso_c dms_e <=> dms_p dhpmp_c + h2o_c --> dhnpt_c + pi_c ahdt_c + h2o_c --> dhpmp_c + h_c + ppi_c 23doguln_c + h_c + nadh_c --> 3dhguln_c + nad_c dopa_e <=> dopa_p doxrbcn_e <=> doxrbcn_p doxrbcn_p + h_p --> doxrbcn_e + h_c atp_c + dpcoa_c --> adp_c + coa_c + h_c 2dhp_c + h_c + nadph_c --> nadp_c + pant__R_c 2dr5p_c --> acald_c + g3p_c dsbard_p + q8_c --> dsbaox_p + q8h2_c dsbard_p + mqn8_c --> dsbaox_p + mql8_c dsbcox_p + 2.0 gthrd_p --> dsbcrd_p + gthox_p dsbdox_c + trdrd_c --> dsbdrd_c + trdox_c dsbgox_p + 2.0 gthrd_p --> dsbgrd_p + gthox_p nadp_c + ser__D_c <=> 2amsa_c + h_c + nadph_c h_p + ser__D_p --> h_c + ser__D_c ser__D_e <=> ser__D_p tartr__D_c --> h2o_c + oaa_c atp_c + dtmp_c <=> adp_c + dtdp_c dtmp_e <=> dtmp_p dump_e <=> dump_p 56dura_c + nad_c <=> h_c + nadh_c + ura_c atp_c + duri_c --> adp_c + dump_c + h_c duri_c + pi_c <=> 2dr1p_c + ura_c duri_p + h_p --> duri_c + h_c duri_e <=> duri_p dutp_c + h2o_c --> dump_c + h_c + ppi_c dxyl5p_c + h_c + nadph_c --> 2me4p_c + nadp_c g3p_c + h_c + pyr_c --> co2_c + dxyl5p_c atp_c + dxyl_c --> adp_c + dxyl5p_c + h_c e4p_c + h2o_c + nad_c <=> 4per_c + 2.0 h_c + nadh_c h_c + nadh_c + tdec2eACP_c --> dcaACP_c + nad_c h_c + nadph_c + tdec2eACP_c --> dcaACP_c + nadp_c h_c + nadh_c + tddec2eACP_c --> ddcaACP_c + nad_c h_c + nadph_c + tddec2eACP_c --> ddcaACP_c + nadp_c h_c + nadh_c + t3c5ddeceACP_c --> cddec5eACP_c + nad_c h_c + nadph_c + t3c5ddeceACP_c --> cddec5eACP_c + nadp_c h_c + nadh_c + tmrs2eACP_c --> myrsACP_c + nad_c h_c + nadph_c + tmrs2eACP_c --> myrsACP_c + nadp_c h_c + nadh_c + t3c7mrseACP_c --> nad_c + tdeACP_c h_c + nadph_c + t3c7mrseACP_c --> nadp_c + tdeACP_c h_c + nadh_c + tpalm2eACP_c --> nad_c + palmACP_c h_c + nadph_c + tpalm2eACP_c --> nadp_c + palmACP_c h_c + nadh_c + t3c9palmeACP_c --> hdeACP_c + nad_c h_c + nadph_c + t3c9palmeACP_c --> hdeACP_c + nadp_c h_c + nadh_c + toctd2eACP_c --> nad_c + ocdcaACP_c h_c + nadph_c + toctd2eACP_c --> nadp_c + ocdcaACP_c h_c + nadh_c + t3c11vaceACP_c --> nad_c + octeACP_c h_c + nadph_c + t3c11vaceACP_c --> nadp_c + octeACP_c but2eACP_c + h_c + nadh_c --> butACP_c + nad_c but2eACP_c + h_c + nadph_c --> butACP_c + nadp_c h_c + nadh_c + thex2eACP_c --> hexACP_c + nad_c h_c + nadph_c + thex2eACP_c --> hexACP_c + nadp_c h_c + nadh_c + toct2eACP_c --> nad_c + ocACP_c h_c + nadph_c + toct2eACP_c --> nadp_c + ocACP_c atp_c + eca4colipa_p + h2o_c --> adp_c + eca4colipa_e + h_c + pi_c colipa_p + eca4und_p --> eca4colipa_p + h_p + udcpdp_p 2.0 unagamuf_p --> eca2und_p + h_p + udcpdp_p eca2und_p + unagamuf_p --> eca3und_p + h_p + udcpdp_p eca3und_p + unagamuf_p --> eca4und_p + h_p + udcpdp_p unagamuf_c --> unagamuf_p 3hbcoa_c <=> b2coa_c + h2o_c 3hhcoa_c <=> h2o_c + hx2coa_c 3hocoa_c <=> h2o_c + oc2coa_c 3hdcoa_c <=> dc2coa_c + h2o_c 3hddcoa_c <=> dd2coa_c + h2o_c 3htdcoa_c <=> h2o_c + td2coa_c 3hhdcoa_c <=> h2o_c + hdd2coa_c 3hodcoa_c <=> h2o_c + od2coa_c 2ddg6p_c --> g3p_c + pyr_c 6pgc_c --> 2ddg6p_c + h2o_c ddcaACP_c + kdo2lipid4_c --> ACP_c + kdo2lipid4L_c kdo2lipid4L_c + myrsACP_c --> ACP_c + lipa_c hdeACP_c + kdo2lipid4_c --> ACP_c + kdo2lipid4p_c kdo2lipid4p_c + myrsACP_c --> ACP_c + lipa_cold_c egmeACP_c + h_c + nadph_c --> gmeACP_c + nadp_c atp_c + enlipa_p + h2o_c --> adp_c + enlipa_e + h_c + pi_c 2pg_c <=> h2o_c + pep_c 3.0 23dhba_c + 3.0 seramp_c --> 6.0 amp_c + enter_c + 9.0 h_c enter_c + 3.0 h2o_c --> 3.0 23dhbzs_c + 3.0 h_c feenter_c + 3.0 h2o_c --> 3.0 23dhbzs_c + fe3_c + 3.0 h_c epmeACP_c + h_c + nadph_c --> nadp_c + pmeACP_c etha_c --> acald_c + nh4_c etha_p + h_p --> etha_c + h_c etha_e <=> etha_p atp_c + ethso3_p + h2o_c --> adp_c + ethso3_c + h_c + pi_c ethso3_e <=> ethso3_p etoh_e <=> etoh_p etoh_p <=> etoh_c f6p_c <=> dha_c + g3p_c f6p_c + h2o_c --> fru_c + pi_c f6p_p + 2.0 pi_c --> f6p_c + 2.0 pi_p f6p_e <=> f6p_p dcaACP_c + h2o_c --> ACP_c + dca_c + h_c ddcaACP_c + h2o_c --> ACP_c + ddca_c + h_c h2o_c + myrsACP_c --> ACP_c + h_c + ttdca_c h2o_c + tdeACP_c --> ACP_c + h_c + ttdcea_c h2o_c + palmACP_c --> ACP_c + h_c + hdca_c h2o_c + hdeACP_c --> ACP_c + h_c + hdcea_c h2o_c + ocACP_c --> ACP_c + h_c + octa_c dcacoa_c + h2o_c --> coa_c + dca_c + h_c ddcacoa_c + h2o_c --> coa_c + ddca_c + h_c h2o_c + tdcoa_c --> coa_c + h_c + ttdca_c h2o_c + tdecoa_c --> coa_c + h_c + ttdcea_c h2o_c + pmtcoa_c --> coa_c + h_c + hdca_c h2o_c + hdcoa_c --> coa_c + h_c + hdcea_c h2o_c + stcoa_c --> coa_c + h_c + ocdca_c h2o_c + odecoa_c --> coa_c + h_c + ocdcea_c h2o_c + hxcoa_c --> coa_c + h_c + hxa_c h2o_c + occoa_c --> coa_c + h_c + octa_c atp_c + coa_c + dca_p + h_p --> amp_c + dcacoa_c + h_c + ppi_c atp_c + coa_c + ddca_p + h_p --> amp_c + ddcacoa_c + h_c + ppi_c atp_c + coa_c + h_p + ttdca_p --> amp_c + h_c + ppi_c + tdcoa_c atp_c + coa_c + h_p + ttdcea_p --> amp_c + h_c + ppi_c + tdecoa_c atp_c + coa_c + h_p + hdca_p --> amp_c + h_c + pmtcoa_c + ppi_c atp_c + coa_c + h_p + hdcea_p --> amp_c + h_c + hdcoa_c + ppi_c atp_c + coa_c + h_p + ocdca_p --> amp_c + h_c + ppi_c + stcoa_c atp_c + coa_c + h_p + ocdcea_p --> amp_c + h_c + odecoa_c + ppi_c atp_c + coa_c + h_p + hxa_p --> amp_c + h_c + hxcoa_c + ppi_c atp_c + coa_c + h_p + octa_p --> amp_c + h_c + occoa_c + ppi_c fad_c + h_c + nadh_c --> fadh2_c + nad_c fad_c + h_c + nadph_c --> fadh2_c + nadp_c hmgth_c + nad_c <=> Sfglutth_c + h_c + nadh_c fald_e <=> fald_p fald_p <=> fald_c fald_c + gthrd_c <=> hmgth_c fdp_c <=> dhap_c + g3p_c s17bp_c <=> dhap_c + e4p_c fdp_c + h2o_c --> f6p_c + pi_c fuc__L_c <=> fcl__L_c atp_c + fcl__L_c --> adp_c + fc1p_c + h_c fc1p_c <=> dhap_c + lald__L_c fe2_c + ppp9_c --> 2.0 h_c + pheme_c for_p + 2.0 h_c + q8_c --> co2_p + h_p + q8h2_c for_p + 2.0 h_c + mqn8_c --> co2_p + h_p + mql8_c fmnh2_c + isetac_c + o2_c --> fmn_c + gcald_c + h2o_c + h_c + so3_c fmnh2_c + mso3_c + o2_c --> fald_c + fmn_c + h2o_c + h_c + so3_c ethso3_c + fmnh2_c + o2_c --> acald_c + fmn_c + h2o_c + h_c + so3_c butso3_c + fmnh2_c + o2_c --> btal_c + fmn_c + h2o_c + h_c + so3_c fmnh2_c + o2_c + sulfac_c --> fmn_c + glx_c + h2o_c + h_c + so3_c atp_c + fe2_p + h2o_c --> adp_c + fe2_c + h_c + pi_c fe2_p + h_p --> fe2_c + h_c fe2_c + h_p --> fe2_p + h_c fe2_e <=> fe2_p fe2_p --> fe2_c atp_c + fe3dcit_p + h2o_c --> adp_c + 2.0 cit_c + fe3_c + h_c + pi_c fe3dcit_e + h_p --> fe3dcit_p + h_c fe3dhbzs_c --> 23dhbzs_c + fe3_c atp_c + fe3dhbzs_p + h2o_c --> adp_c + fe3dhbzs_c + h_c + pi_c fe3dhbzs_e + h_p --> fe3dhbzs_p + h_c fadh2_c + 2.0 fe3hox_c --> fad_c + 2.0 fe2_c + 2.0 fe3hox_un_c + 2.0 h_c 2.0 fe3hox_c + fmnh2_c --> 2.0 fe2_c + 2.0 fe3hox_un_c + fmn_c + 2.0 h_c 2.0 fe3hox_c + rbflvrd_c --> 2.0 fe2_c + 2.0 fe3hox_un_c + 2.0 h_c + ribflv_c fe3hox_un_c + h_p --> fe3hox_un_p + h_c fe3hox_un_p + h_p --> fe3hox_un_e + h_c atp_c + fe3hox_p + h2o_c --> adp_c + fe3hox_c + h_c + pi_c fe3_e + fe3hox_un_e --> fe3hox_e fe3hox_e + h_p --> fe3hox_p + h_c fadh2_c + 2.0 fe3_c --> fad_c + 2.0 fe2_c + 2.0 h_c atp_c + fe3_p + h2o_c --> adp_c + fe3_c + h_c + pi_c fe3_e <=> fe3_p fadh2_c + 2.0 fecrm_c --> fad_c + 2.0 fe2_c + 2.0 fecrm_un_c + 2.0 h_c 2.0 fecrm_c + fmnh2_c --> 2.0 fe2_c + 2.0 fecrm_un_c + fmn_c + 2.0 h_c 2.0 fecrm_c + rbflvrd_c --> 2.0 fe2_c + 2.0 fecrm_un_c + 2.0 h_c + ribflv_c fecrm_un_p + h_p --> fecrm_un_e + h_c fecrm_un_c + h_p --> fecrm_un_p + h_c atp_c + fecrm_p + h2o_c --> adp_c + fecrm_c + h_c + pi_c fe3_e + fecrm_un_e --> fecrm_e fecrm_e + h_p --> fecrm_p + h_c fadh2_c + 2.0 feenter_c --> 2.0 enter_c + fad_c + 2.0 fe2_c + 2.0 h_c 2.0 feenter_c + fmnh2_c --> 2.0 enter_c + 2.0 fe2_c + fmn_c + 2.0 h_c 2.0 feenter_c + rbflvrd_c --> 2.0 enter_c + 2.0 fe2_c + 2.0 h_c + ribflv_c atp_c + feenter_p + h2o_c --> adp_c + feenter_c + h_c + pi_c enter_e + fe3_e --> feenter_e enter_p + h_p --> enter_e + h_c feenter_e + h_p --> feenter_p + h_c enter_c + h_p --> enter_p + h_c fadh2_c + 2.0 feoxam_c --> fad_c + 2.0 fe2_c + 2.0 feoxam_un_c + 2.0 h_c 2.0 feoxam_c + fmnh2_c --> 2.0 fe2_c + 2.0 feoxam_un_c + fmn_c + 2.0 h_c 2.0 feoxam_c + rbflvrd_c --> 2.0 fe2_c + 2.0 feoxam_un_c + 2.0 h_c + ribflv_c feoxam_un_p + h_p --> feoxam_un_e + h_c feoxam_un_c + h_p --> feoxam_un_p + h_c atp_c + feoxam_p + h2o_c --> adp_c + feoxam_c + h_c + pi_c fe3_e + feoxam_un_e --> feoxam_e feoxam_e + h_p --> feoxam_p + h_c 4.0 fe2_p + 4.0 h_p + o2_p --> 4.0 fe3_p + 2.0 h2o_p 2.0 4fe4s_c + h2o2_c + 2.0 h_c --> 2.0 3fe4s_c + 2.0 fe3_c + 2.0 h2o_c 2.0 4fe4s_c + 2.0 h_c + 2.0 no_c --> 2.0 3fe4s_c + 2.0 fe3_c + h2o_c + n2o_c 3fe4s_c + fe2_c --> 4fe4s_c h2o_c + suc6p_c --> fru_c + g6p_c for_c + h_c --> co2_c + h2_c 2.0 flxso_c + nadph_c --> 2.0 flxr_c + h_c + nadp_c h_c + nadph_c + ribflv_c --> nadp_c + rbflvrd_c h_c + nadh_c + ribflv_c --> nad_c + rbflvrd_c 10fthf_c + mettrna_c --> fmettrna_c + h_c + thf_c atp_c + fmn_c + h_c --> fad_c + ppi_c fmn_c + h_c + nadh_c --> fmnh2_c + nad_c fmn_c + h_c + nadph_c --> fmnh2_c + nadp_c 5fthf_c + h_c --> h2o_c + methf_c forcoa_c + oxa_c <=> for_c + oxalcoa_c for_p + h_p --> for_c + h_c for_e <=> for_p for_c --> for_p fum_c + mql8_c --> mqn8_c + succ_c 2dmmql8_c + fum_c --> 2dmmq8_c + succ_c atp_c + f1p_c --> adp_c + fdp_c + h_c frulysp_c + h2o_c <=> g6p_c + lys__L_c psclys_c <=> frulys_c atp_c + frulys_c --> adp_c + frulysp_c + h_c frulys_p + h_p --> frulys_c + h_c frulys_e <=> frulys_p fruur_p + h_p <=> fruur_c + h_c fruur_e <=> fruur_p fru_p + pep_c --> f6p_c + pyr_c fru_p + pep_c --> f1p_c + pyr_c fru_e <=> fru_p 10fthf_c + h2o_c --> for_c + h_c + thf_c atp_c + for_c + thf_c --> 10fthf_c + adp_c + pi_c fuc__L_e <=> fuc__L_p fuc__L_p + h_p <=> fuc__L_c + h_c fum_c + h2o_c <=> mal__L_c fum_p + 2.0 h_p --> fum_c + 2.0 h_c fum_p + 3.0 h_p --> fum_c + 3.0 h_c fum_e <=> fum_p fusa_e <=> fusa_p fusa_p + h_p --> fusa_e + h_c accoa_c + gam1p_c --> acgam1p_c + coa_c + h_c g1p_p + h2o_p --> glc__D_p + pi_p dttp_c + g1p_c + h_c --> dtdpglu_c + ppi_c g1p_e <=> g1p_p glu1sa_c <=> 5aop_c glyc2p_c + h2o_c --> glyc_c + pi_c glyc2p_p + h2o_p --> glyc_p + pi_p ddcaACP_c + glyc3p_c --> 1ddecg3p_c + ACP_c glyc3p_c + myrsACP_c --> 1tdecg3p_c + ACP_c glyc3p_c + tdeACP_c --> 1tdec7eg3p_c + ACP_c glyc3p_c + palmACP_c --> 1hdecg3p_c + ACP_c glyc3p_c + hdeACP_c --> 1hdec9eg3p_c + ACP_c glyc3p_c + ocdcaACP_c --> 1odecg3p_c + ACP_c glyc3p_c + octeACP_c --> 1odec11eg3p_c + ACP_c atp_c + g3pc_p + h2o_c --> adp_c + g3pc_c + h_c + pi_c g3pc_e <=> g3pc_p glyc3p_c + nadp_c <=> dhap_c + h_c + nadph_c glyc3p_c + q8_c --> dhap_c + q8h2_c glyc3p_c + mqn8_c --> dhap_c + mql8_c 2dmmq8_c + glyc3p_c --> 2dmmql8_c + dhap_c atp_c + g3pe_p + h2o_c --> adp_c + g3pe_c + h_c + pi_c g3pe_e <=> g3pe_p atp_c + g3pg_p + h2o_c --> adp_c + g3pg_c + h_c + pi_c g3pg_e <=> g3pg_p atp_c + g3pi_p + h2o_c --> adp_c + g3pi_c + h_c + pi_c g3pi_e <=> g3pi_p atp_c + g3ps_p + h2o_c --> adp_c + g3ps_c + h_c + pi_c g3ps_e <=> g3ps_p glyc3p_c + h2o_c --> glyc_c + pi_c glu5sa_c --> 1pyr5c_c + h2o_c + h_c glu5p_c + h_c + nadph_c --> glu5sa_c + nadp_c + pi_c gam6p_c + h2o_c --> f6p_c + nh4_c g6p_c + nadp_c <=> 6pgl_c + h_c + nadph_c g6p_c + h2o_c --> glc__D_c + pi_c g6p_p + 2.0 pi_c --> g6p_c + 2.0 pi_p g6p_e <=> g6p_p gal1p_p + h2o_p --> gal_p + pi_p gal1p_e <=> gal1p_p gal_bD_e <=> gal_bD_p galct__D_c --> 5dh4dglc_c + h2o_c galctn__L_c + nad_c --> h_c + nadh_c + tagur_c galctn__D_c --> 2dh3dgal_c + h2o_c galctn__L_p + h_p --> galctn__L_c + h_c galctn__L_e <=> galctn__L_p galctn__D_p + h_p --> galctn__D_c + h_c galctn__D_e <=> galctn__D_p galct__D_p + h_p <=> galct__D_c + h_c galct__D_e <=> galct__D_p atp_c + gal_c <=> adp_c + gal1p_c + h_c gal_bD_p --> gal_p h2o_c + melib_c --> gal_c + glc__D_c gicolipa_c + udpg_c --> gagicolipa_c + h_c + udp_c galt_p + pep_c --> galt1p_c + pyr_c galt_e <=> galt_p galur_p + h_p <=> galur_c + h_c galur_e <=> galur_p g1p_c + h_c + utp_c --> ppi_c + udpg_c atp_c + gal_p + h2o_c --> adp_c + gal_c + h_c + pi_c gal_p + h_p --> gal_c + h_c gal_e <=> gal_p gam6p_p + 2.0 pi_c --> gam6p_c + 2.0 pi_p gam6p_e <=> gam6p_p gam_p + pep_c --> gam6p_c + pyr_c gam_e <=> gam_p g3p_c + nad_c + pi_c <=> 13dpg_c + h_c + nadh_c 10fthf_c + gar_c <=> fgam_c + h_c + thf_c atp_c + for_c + gar_c --> adp_c + fgam_c + h_c + pi_c gbbtn_e <=> gbbtn_p gcald_c + h2o_c + nad_c --> glyclt_c + 2.0 h_c + nadh_c gdpddman_c --> gdpofuc_c atp_c + gdp_c --> amp_c + h_c + ppgpp_c gdpmann_c + h2o_c --> gdp_c + h_c + man_c gdpmann_c + h2o_c --> gmp_c + 2.0 h_c + man1p_c gdptp_c + h2o_c --> gtp_c + ppi_c gdp_e <=> gdp_p f6p_c + gln__L_c --> gam6p_c + glu__L_c ggbutal_c + h2o_c + nadp_c <=> gg4abut_c + 2.0 h_c + nadph_c gg4abut_c + h2o_c --> 4abut_c + glu__L_c ggptrc_c + h2o_c + o2_c --> ggbutal_c + h2o2_c + nh4_c atp_c + glu__L_c + ptrc_c --> adp_c + ggptrc_c + h_c + pi_c h_c + nadh_c + sucsal_c <=> ghb_c + nad_c ser__L_c + thf_c <=> gly_c + h2o_c + mlthf_c atp_c + gmp_c <=> adp_c + gdp_c glycogen_c --> bglycogen_c accoa_c + glc__D_c <=> acglc__D_c + coa_c glc__D_p + h2o_p + q8_c --> glcn_p + h_p + q8h2_c glcn_p + h_p <=> glcn_c + h_c glcn_e <=> glcn_p glycogen_c + pi_c --> g1p_c bglycogen_c + pi_c --> g1p_c 5dh4dglc_c --> 2h3oppan_c + pyr_c glcr_c --> 5dh4dglc_c + h2o_c glcr_p + h_p <=> glcr_c + h_c glcr_e <=> glcr_p adpglc_c --> adp_c + glycogen_c + h_c icolipa_c + udpg_c --> gicolipa_c + h_c + udp_c gagicolipa_c + udpg_c --> ggagicolipa_c + h_c + udp_c ggagicolipa_c + udpg_c --> gggagicolipa_c + h_c + udp_c glcur1p_e <=> glcur1p_p glcur_p + h_p <=> glcur_c + h_c glcur_e <=> glcur_p atp_c + glc__D_p + h2o_c --> adp_c + glc__D_c + h_c + pi_c glc__D_p + pep_c --> g6p_c + pyr_c glc__D_p + h_p --> glc__D_c + h_c glc__D_e <=> glc__D_p glc__D_e --> glc__D_p bglycogen_c --> glycogen_c atp_c + g1p_c + h_c --> adpglc_c + ppi_c atp_c + glu__L_c + nh4_c --> adp_c + gln__L_c + h_c + pi_c atp_c + gln__L_c + trnagln_c --> amp_c + glntrna_c + ppi_c atp_c + gln__L_p + h2o_c --> adp_c + gln__L_c + h_c + pi_c gln__L_e <=> gln__L_p galt1p_c + nad_c <=> h_c + nadh_c + tag6p__D_c atp_c + glu__L_c --> adp_c + glu5p_c 4abut_c + glu__L_p <=> 4abut_p + glu__L_c atp_c + cys__L_c + glu__L_c --> adp_c + glucys_c + h_c + pi_c glu__L_c + h_c --> 4abut_c + co2_c glu__L_c + h2o_c + nadp_c <=> akg_c + h_c + nadph_c + nh4_c gln__L_c + h2o_c --> glu__L_c + nh4_c gln__L_p + h2o_p --> glu__L_p + nh4_p gln__L_c + h2o_c + prpp_c --> glu__L_c + ppi_c + pram_c glu__D_c <=> glu__L_c akg_c + gln__L_c + h_c + nadph_c --> 2.0 glu__L_c + nadp_c glutrna_c + h_c + nadph_c --> glu1sa_c + nadp_c + trnaglu_c atp_c + glu__L_c + trnaglu_c --> amp_c + glutrna_c + ppi_c atp_c + glu__L_p + h2o_c --> adp_c + glu__L_c + h_c + pi_c glu__L_p + h_p <=> glu__L_c + h_c glu__L_p + na1_p --> glu__L_c + na1_c glu__L_e <=> glu__L_p 2.0 glx_c + h_c --> 2h3oppan_c + co2_c glyald_e <=> glyald_p glyald_p <=> glyald_c accoa_c + gly_c <=> 2aobut_c + coa_c atp_c + glyb_p + h2o_c --> adp_c + glyb_c + h_c + pi_c glyb_p + h_p --> glyb_c + h_c glyb_e <=> glyb_p atp_c + glyc2p_p + h2o_c --> adp_c + glyc2p_c + h_c + pi_c glyc2p_e <=> glyc2p_p atp_c + glyc3p_p + h2o_c --> adp_c + glyc3p_c + h_c + pi_c glyc3p_p + pi_c --> glyc3p_c + pi_p glyc3p_e <=> glyc3p_p glyc__R_p + h_p <=> glyc__R_c + h_c glyc__R_e <=> glyc__R_p glyc_c + nad_c --> dha_c + h_c + nadh_c atp_c + glyc__R_c --> 3pg_c + adp_c + h_c atp_c + glyc__R_c --> 2pg_c + adp_c + h_c gly_c + nad_c + thf_c --> co2_c + mlthf_c + nadh_c + nh4_c glx_c + h_c + nadh_c --> glyclt_c + nad_c glx_c + h_c + nadph_c --> glyclt_c + nadp_c glyclt_p + h_p <=> glyclt_c + h_c glyclt_p + na1_p --> glyclt_c + na1_c glyclt_e <=> glyclt_p glyclt_c + q8_c --> glx_c + q8h2_c glyclt_c + mqn8_c --> glx_c + mql8_c 2dmmq8_c + glyclt_c --> 2dmmql8_c + glx_c glyc_e <=> glyc_p glyc_c <=> glyc_p atp_c + glyc_c --> adp_c + glyc3p_c + h_c h2o_c + lgt__S_c --> gthrd_c + h_c + lac__D_c h2o_c + mthgxl_c --> h_c + lac__D_c atp_c + gly_c + trnagly_c --> amp_c + glytrna_c + ppi_c gly_p + h_p --> gly_c + h_c gly_p + h_p <=> gly_c + h_c gly_p + na1_p --> gly_c + na1_c gly_e <=> gly_p gdpmann_c --> gdpddman_c + h2o_c atp_c + gmhep1p_c + h_c --> adphep_DD_c + ppi_c atp_c + gmhep7p_c --> adp_c + gmhep17bp_c + h_c gmhep17bp_c + h2o_c --> gmhep1p_c + pi_c gmp_c + 2.0 h_c + nadph_c --> imp_c + nadp_c + nh4_c atp_c + gln__L_c + h2o_c + xmp_c --> amp_c + glu__L_c + gmp_c + 2.0 h_c + ppi_c gmp_e <=> gmp_p 6pgc_c + nadp_c --> co2_c + nadph_c + ru5p__D_c atp_c + glcn_c --> 6pgc_c + adp_c + h_c gdpofuc_c + h_c + nadph_c --> gdpfuc_c + nadp_c gp4g_c + h2o_c --> 2.0 gdp_c + 2.0 h_c g3pc_c + h2o_c --> chol_c + glyc3p_c + h_c g3pc_p + h2o_p --> chol_p + glyc3p_p + h_p g3pe_c + h2o_c --> etha_c + glyc3p_c + h_c g3pe_p + h2o_p --> etha_p + glyc3p_p + h_p g3ps_c + h2o_c --> glyc3p_c + h_c + ser__L_c g3ps_p + h2o_p --> glyc3p_p + h_p + ser__L_p g3pg_c + h2o_c --> glyc3p_c + glyc_c + h_c g3pg_p + h2o_p --> glyc3p_p + glyc_p + h_p g3pi_c + h2o_c --> glyc3p_c + h_c + inost_c g3pi_p + h2o_p --> glyc3p_p + h_p + inost_p grdp_c + ipdp_c --> frdp_c + ppi_c grxox_c + 2.0 gthrd_c --> grxrd_c + gthox_c atp_c + gsn_c --> adp_c + gmp_c + h_c gsn_p + h_p --> gsn_c + h_c gsn_e <=> gsn_p gtspmd_c + h2o_c --> gthrd_c + spmd_c atp_c + gthrd_c + spmd_c --> adp_c + gtspmd_c + h_c + pi_c gthox_e <=> gthox_p gthox_c + h_c + nadph_c <=> 2.0 gthrd_c + nadp_c 2.0 gthrd_c + h2o2_c --> gthox_c + 2.0 h2o_c gthrd_p + h2o_p --> cgly_p + glu__L_p atp_c + gthrd_c + h2o_c --> adp_c + gthrd_p + h_c + pi_c atp_c + gthrd_p + h2o_c --> adp_c + gthrd_c + h_c + pi_c gthrd_e <=> gthrd_p atp_c + glucys_c + gly_c --> adp_c + gthrd_c + h_c + pi_c gtp_c + h2o_c --> ahdt_c + for_c + h_c gtp_c + 3.0 h2o_c --> 25drapp_c + for_c + 2.0 h_c + ppi_c gdptp_c + h2o_c --> h_c + pi_c + ppgpp_c atp_c + gtp_c --> amp_c + gdptp_c + h_c gtp_c + h2o_c + h_c --> nh4_c + xtp_c gtp_e <=> gtp_p gtp_c --> 35cgmp_c + ppi_c gua_c + h2o_c + h_c --> nh4_c + xan_c gua_c + prpp_c --> gmp_c + ppi_c gua_p + h_p --> gua_c + h_c gua_e <=> gua_p gua_p <=> gua_c glcur_c <=> fruur_c galur_c <=> tagur_c glcur1p_p + h2o_p --> glcur_p + pi_p h2o2_e <=> h2o2_p h2o_e <=> h2o_p h2o_p <=> h2o_c h2s_c + 2.0 o2_c --> 2.0 h_c + so4_c h2s_c --> h2s_p h2s_e <=> h2s_p h2_e <=> h2_p h2_p <=> h2_c aacoa_c + h_c + nadh_c <=> 3hbcoa_c + nad_c 3ohcoa_c + h_c + nadh_c <=> 3hhcoa_c + nad_c 3oocoa_c + h_c + nadh_c <=> 3hocoa_c + nad_c 3odcoa_c + h_c + nadh_c <=> 3hdcoa_c + nad_c 3oddcoa_c + h_c + nadh_c <=> 3hddcoa_c + nad_c 3otdcoa_c + h_c + nadh_c <=> 3htdcoa_c + nad_c 3ohdcoa_c + h_c + nadh_c <=> 3hhdcoa_c + nad_c 3ohodcoa_c + h_c + nadh_c <=> 3hodcoa_c + nad_c 3hadpcoa_c + nad_c <=> h_c + nadh_c + oxadpcoa_c 4hbz_c + octdp_c --> 3ophb_c + ppi_c 3hcinnm_p + h_p <=> 3hcinnm_c + h_c 3hcinnm_e <=> 3hcinnm_p co2_c + h2o_c <=> h_c + hco3_c amet_c + hcys__L_c --> ahcys_c + h_c + met__L_c hcys__L_c + mmet_c --> h_c + 2.0 met__L_c hdca_e --> hdca_p hdcea_e --> hdcea_p frdp_c + h2o_c + pheme_c --> hemeO_c + ppi_c atp_c + hhlipa_c --> adp_c + h_c + phhlipa_c atp_c + hphhlipa_c --> adp_c + h_c + phphhlipa_c adphep_LD_c + lipa_c --> adp_c + h_c + hlipa_c adphep_LD_c + hlipa_c --> adp_c + h_c + hhlipa_c adphep_LD_c + phhlipa_c --> adp_c + h_c + hphhlipa_c adphep_LD_c + gggagicolipa_c --> adp_c + colipa_c + h_c 4mhetz_c + atp_c --> 4mpetz_c + adp_c + h_c atp_c + glc__D_c --> adp_c + g6p_c + h_c atp_c + man_c --> adp_c + h_c + man6p_c atp_c + fru_c --> adp_c + f6p_c + h_c h_p + hxa_p <=> h_c + hxa_c atp_c + h2o_c + hg2_c --> adp_c + h_c + hg2_p + pi_c h_p + hg2_c --> h_c + hg2_p hg2_e <=> hg2_p h2o_c + histd_c + 2.0 nad_c --> 3.0 h_c + his__L_c + 2.0 nadh_c h2o_c + hisp_c --> histd_c + pi_c atp_c + his__L_c + trnahis_c --> amp_c + histrna_c + ppi_c atp_c + h2o_c + his__L_p --> adp_c + h_c + his__L_c + pi_c h_p + his__L_p <=> h_c + his__L_c his__L_e <=> his__L_p h2o_c + hkndd_c --> h_c + op4en_c + succ_c h2o_c + hkntd_c --> fum_c + h_c + op4en_c h2o_c + 4.0 ppbng_c --> hmbil_c + 4.0 nh4_c 4ahmmp_c + atp_c --> 4ampm_c + adp_c + h_c h_p + hom__L_c --> h_c + hom__L_p hom__L_e <=> hom__L_p 4h2opntn_c --> acald_c + pyr_c 6hmhpt_c + atp_c --> 6hmhptpp_c + amp_c + h_c dhpppn_c + o2_c --> h_c + hkndd_c 3hpppn_p + h_p <=> 3hpppn_c + h_c 3hpppn_e <=> 3hpppn_p hpyr_c <=> 2h3oppan_c h_c + hpyr_c + nadh_c --> glyc__R_c + nad_c h_c + hpyr_c + nadph_c --> glyc__R_c + nadp_c hom__L_c + nadp_c <=> aspsa_c + h_c + nadph_c atp_c + hom__L_c --> adp_c + h_c + phom_c hom__L_c + succoa_c --> coa_c + suchms_c glu__L_c + imacp_c --> akg_c + hisp_c h2o_c + hxan_c + nad_c --> h_c + nadh_c + xan_c hxa_e <=> hxa_p accoa_c + hxa_c --> ac_c + hxcoa_c hxan_c + prpp_c --> imp_c + ppi_c h2_c + 2.0 h_c + q8_c --> 2.0 h_p + q8h2_c h2_c + 2.0 h_c + mqn8_c --> 2.0 h_p + mql8_c 2dmmq8_c + h2_c + 2.0 h_c --> 2dmmql8_c + 2.0 h_p h2o_c + pyam5p_c --> pi_c + pydam_c hxan_e <=> hxan_p hxan_p <=> hxan_c h_e <=> h_p 2fe1s_c + iscssh_c + iscu_c --> 4.0 h_c + iscs_c + iscu_2fe2s_c fadh2_c + 2.0 fe2_c + 2.0 iscssh_c + iscu_c --> fad_c + 6.0 h_c + 2.0 iscs_c + iscu_2fe2s_c fadh2_c + 2.0 fe2_c + 2.0 iscssh_c + iscu_2fe2s_c --> fad_c + 6.0 h_c + 2.0 iscs_c + iscu_2fe2s2_c 4.0 h_c + iscu_2fe2s_c --> 2fe2s_c + iscu_c fadh2_c + 2.0 h_c + iscu_2fe2s2_c --> fad_c + iscu_4fe4s_c 4.0 h_c + iscu_4fe4s_c --> 4fe4s_c + iscu_c icit_c + nadp_c <=> akg_c + co2_c + nadph_c chor_c <=> ichor_c chor_c --> ichor_c h2o_c + ichor_c --> 23ddhb_c + pyr_c icit_c --> glx_c + succ_c cys__L_c + iscs_c --> ala__L_c + iscssh_c 5dglcn_c + h_c + nadh_c <=> idon__L_c + nad_c 5dglcn_c + h_c + nadph_c --> idon__L_c + nadp_c h_p + idon__L_p <=> h_c + idon__L_c idon__L_e <=> idon__L_p gln__L_c + prlp_c --> aicar_c + eig3p_c + glu__L_c + h_c eig3p_c --> h2o_c + imacp_c 2cpr5p_c + h_c --> 3ig3p_c + co2_c + h2o_c akg_c + ile__L_c <=> 3mop_c + glu__L_c atp_c + ile__L_c + trnaile_c --> amp_c + iletrna_c + ppi_c atp_c + h2o_c + ile__L_p --> adp_c + h_c + ile__L_c + pi_c h_p + ile__L_p <=> h_c + ile__L_c ile__L_e <=> ile__L_p h2o_c + imp_c <=> fprica_c h2o_c + imp_c + nad_c --> h_c + nadh_c + xmp_c imp_e <=> imp_p h_c + indole_c --> h_p + indole_p h_p + indole_p <=> h_c + indole_c indole_e <=> indole_p inost_p + na1_p --> inost_c + na1_c h2o_c + ins_c --> hxan_c + rib__D_c atp_c + ins_c --> adp_c + h_c + imp_c inost_e <=> inost_p h_p + ins_p --> h_c + ins_c h_p + ins_p <=> h_c + ins_c ins_e <=> ins_p ipdp_c <=> dmpp_c h2mb4p_c + h_c + nadh_c --> h2o_c + ipdp_c + nad_c 3c2hmp_c + nad_c --> 3c4mop_c + h_c + nadh_c 3c2hmp_c <=> 2ippm_c + h2o_c 2ippm_c + h2o_c <=> 3c3hmp_c 3mob_c + accoa_c + h2o_c --> 3c3hmp_c + coa_c + h_c atp_c + h2o_c + isetac_p --> adp_c + h_c + isetac_c + pi_c isetac_e <=> isetac_p atp_c + h2o_c + kdo2lipid4_c --> adp_c + h_c + kdo2lipid4_p + pi_c atp_c + h2o_c + kdo2lipid4_p --> adp_c + h_c + kdo2lipid4_e + pi_c 23dhmb_c + nadp_c <=> alac__S_c + h_c + nadph_c 2ahbut_c + h_c + nadph_c <=> 23dhmp_c + nadp_c acACP_c + h_c + malACP_c --> ACP_c + actACP_c + co2_c accoa_c + h_c + malACP_c --> actACP_c + co2_c + coa_c ctp_c + kdo_c --> ckdo_c + ppi_c h2o_c + kdo8p_c --> kdo_c + pi_c ara5p_c + h2o_c + pep_c --> kdo8p_c + pi_c 3dhgulnp_c + h_c --> co2_c + xu5p__L_c atp_c + h2o_c + k_p --> adp_c + h_c + k_c + pi_c h_p + k_p --> h_c + k_c h_p + k_c --> h_c + k_p k_e <=> k_p lac__L_c + q8_c --> pyr_c + q8h2_c lac__L_c + mqn8_c --> mql8_c + pyr_c h_p + lac__L_p <=> h_c + lac__L_c lac__L_e <=> lac__L_p colipa_p + uLa4n_p --> acolipa_p + udcpp_p h2o_c + lcts_c --> gal_c + glc__D_c h2o_p + lcts_p --> gal_p + glc__D_p LalaDgluMdap_c + h2o_c --> 26dap__M_c + LalaDglu_c LalaDglu_e <=> LalaDglu_p LalaDglu_p + h_p --> LalaDglu_c + h_c LalaLglu_e <=> LalaLglu_p LalaLglu_p + h_p --> LalaLglu_c + h_c h_c + mthgxl_c + nadh_c --> lald__D_c + nad_c h_c + mthgxl_c + nadph_c --> lald__L_c + nadp_c LalaLglu_c + h2o_c --> ala__L_c + glu__L_c h2o_c + lald__L_c + nad_c --> 2.0 h_c + lac__L_c + nadh_c h_c + lald__D_c + nadh_c <=> 12ppd__R_c + nad_c h_c + lald__L_c + nadh_c <=> 12ppd__S_c + nad_c h_p + lcts_c --> h_c + lcts_p lcts_e <=> lcts_p h_p + lcts_p <=> h_c + lcts_c lac__D_c + nad_c <=> h_c + nadh_c + pyr_c lac__D_c + q8_c --> pyr_c + q8h2_c 4mop_c + glu__L_c --> akg_c + leu__L_c atp_c + leu__L_c + trnaleu_c --> amp_c + leutrna_c + ppi_c atp_c + h2o_c + leu__L_p --> adp_c + h_c + leu__L_c + pi_c h_p + leu__L_p <=> h_c + leu__L_c leu__L_e <=> leu__L_p gthrd_c + mthgxl_c --> lgt__S_c atp_c + h2o_c + lipa_cold_c --> adp_c + h_c + lipa_cold_p + pi_c colipa_e + h_e + hdca_e --> h2o_e + hacolipa_e h_e + hdca_e + lipa_e --> h2o_e + halipa_e lipoamp_c --> amp_c + lipopb_c atp_c + lipoate_c --> lipoamp_c + ppi_c atp_c + h2o_c + lipa_c --> adp_c + h_c + lipa_p + pi_c atp_c + h2o_c + lipa_p --> adp_c + h_c + lipa_e + pi_c h_c + ocACP_c --> ACP_c + octapb_c 4fe4s_c + 2.0 amet_c + h_c + nad_c + octapb_c --> 2fe2s_c + 2.0 dad_5_c + 2.0 fe2_c + lipopb_c + 2.0 met__L_c + nadh_c h_p + lipoate_p --> h_c + lipoate_c lipoate_e <=> lipoate_p lipidX_c + u23ga_c --> h_c + lipidAds_c + udp_c 1ddecg3p_p + h2o_p --> ddca_p + glyc3p_p + h_p 1tdecg3p_p + h2o_p --> glyc3p_p + h_p + ttdca_p 1tdec7eg3p_p + h2o_p --> glyc3p_p + h_p + ttdcea_p 1hdecg3p_p + h2o_p --> glyc3p_p + h_p + hdca_p 1hdec9eg3p_p + h2o_p --> glyc3p_p + h_p + hdcea_p 1odecg3p_p + h2o_p --> glyc3p_p + h_p + ocdca_p 1odec11eg3p_p + h2o_p --> glyc3p_p + h_p + ocdcea_p 1agpe120_p + h2o_p --> ddca_p + g3pe_p + h_p 1agpe140_p + h2o_p --> g3pe_p + h_p + ttdca_p 1agpe141_p + h2o_p --> g3pe_p + h_p + ttdcea_p 1agpe160_p + h2o_p --> g3pe_p + h_p + hdca_p 1agpe161_p + h2o_p --> g3pe_p + h_p + hdcea_p 1agpe180_p + h2o_p --> g3pe_p + h_p + ocdca_p 1agpe181_p + h2o_p --> g3pe_p + h_p + ocdcea_p 1agpg120_p + h2o_p --> ddca_p + g3pg_p + h_p 1agpg140_p + h2o_p --> g3pg_p + h_p + ttdca_p 1agpg141_p + h2o_p --> g3pg_p + h_p + ttdcea_p 1agpg160_p + h2o_p --> g3pg_p + h_p + hdca_p 1agpg161_p + h2o_p --> g3pg_p + h_p + hdcea_p 1agpg180_p + h2o_p --> g3pg_p + h_p + ocdca_p 1agpg181_p + h2o_p --> g3pg_p + h_p + ocdcea_p 2ddecg3p_c + h2o_c --> ddca_c + glyc3p_c + 2.0 h_c 2tdecg3p_c + h2o_c --> glyc3p_c + 2.0 h_c + ttdca_c 2tdec7eg3p_c + h2o_c --> glyc3p_c + 2.0 h_c + ttdcea_c 2hdecg3p_c + h2o_c --> glyc3p_c + 2.0 h_c + hdca_c 2hdec9eg3p_c + h2o_c --> glyc3p_c + 2.0 h_c + hdcea_c 2odecg3p_c + h2o_c --> glyc3p_c + 2.0 h_c + ocdca_c 2odec11eg3p_c + h2o_c --> glyc3p_c + 2.0 h_c + ocdcea_c 2agpe120_c + pg120_c --> apg120_c + g3pe_c 2agpe140_c + pg140_c --> apg140_c + g3pe_c 2agpe141_c + pg141_c --> apg141_c + g3pe_c 2agpe160_c + pg160_c --> apg160_c + g3pe_c 2agpe161_c + pg161_c --> apg161_c + g3pe_c 2agpe180_c + pg180_c --> apg180_c + g3pe_c 2agpe181_c + pg181_c --> apg181_c + g3pe_c 2agpg120_c + pg120_c --> apg120_c + g3pg_c 2agpg140_c + pg140_c --> apg140_c + g3pg_c 2agpg141_c + pg141_c --> apg141_c + g3pg_c 2agpg160_c + pg160_c --> apg160_c + g3pg_c 2agpg161_c + pg161_c --> apg161_c + g3pg_c 2agpg180_c + pg180_c --> apg180_c + g3pg_c 2agpg181_c + pg181_c --> apg181_c + g3pg_c 2agpe120_c + h2o_c --> ddca_c + g3pe_c + h_c 2agpe140_c + h2o_c --> g3pe_c + h_c + ttdca_c 2agpe141_c + h2o_c --> g3pe_c + h_c + ttdcea_c 2agpe160_c + h2o_c --> g3pe_c + h_c + hdca_c 2agpe161_c + h2o_c --> g3pe_c + h_c + hdcea_c 2agpe180_c + h2o_c --> g3pe_c + h_c + ocdca_c 2agpe181_c + h2o_c --> g3pe_c + h_c + ocdcea_c 2agpg120_c + h2o_c --> ddca_c + g3pg_c + h_c 2agpg140_c + h2o_c --> g3pg_c + h_c + ttdca_c 2agpg141_c + h2o_c --> g3pg_c + h_c + ttdcea_c 2agpg160_c + h2o_c --> g3pg_c + h_c + hdca_c 2agpg161_c + h2o_c --> g3pg_c + h_c + hdcea_c 2agpg180_c + h2o_c --> g3pg_c + h_c + ocdca_c 2agpg181_c + h2o_c --> g3pg_c + h_c + ocdcea_c nadp_c + ser__L_c <=> 2amsa_c + h_c + nadph_c h_c + lys__L_c --> 15dap_c + co2_c atp_c + lys__L_c + trnalys_c --> amp_c + lystrna_c + ppi_c atp_c + h2o_c + lys__L_p --> adp_c + h_c + lys__L_c + pi_c h_p + lys__L_p --> h_c + lys__L_c h_p + lys__L_c --> h_c + lys__L_p lys__L_e <=> lys__L_p lyx__L_c --> xylu__L_c h_p + lyx__L_p --> h_c + lyx__L_c lyx__L_e <=> lyx__L_p mnl1p_c + nad_c <=> f6p_c + h_c + nadh_c h_c + malACP_c --> acACP_c + co2_c amet_c + malcoa_c --> ahcys_c + malcoame_c mal__D_c + nad_c --> co2_c + nadh_c + pyr_c 2.0 h_p + mal__D_p --> 2.0 h_c + mal__D_c mal__D_e <=> mal__D_p accoa_c + glx_c + h2o_c --> coa_c + h_c + mal__L_c accoa_c + malt_c <=> acmalt_c + coa_c atp_c + h2o_c + malthx_p --> adp_c + h_c + malthx_c + pi_c malthx_e --> malthx_p atp_c + h2o_c + maltpt_p --> adp_c + h_c + maltpt_c + pi_c maltpt_e --> maltpt_p atp_c + h2o_c + malttr_p --> adp_c + h_c + malttr_c + pi_c malttr_e --> malttr_p atp_c + h2o_c + maltttr_p --> adp_c + h_c + maltttr_c + pi_c maltttr_e --> maltttr_p atp_c + h2o_c + malt_p --> adp_c + h_c + malt_c + pi_c malt_p + pep_c --> malt6p_c + pyr_c malt_e --> malt_p 2.0 h_p + mal__L_p --> 2.0 h_c + mal__L_c 3.0 h_p + mal__L_p --> 3.0 h_c + mal__L_c h_p + mal__L_c --> h_c + mal__L_p mal__L_e <=> mal__L_p gdp_c + h_c + man1p_c --> gdpmann_c + pi_c man6p_c <=> f6p_c man6p_p + 2.0 pi_c --> man6p_c + 2.0 pi_p man6p_e <=> man6p_p mana_c + nad_c <=> fruur_c + h_c + nadh_c manglyc_p + pep_c --> man6pglyc_c + pyr_c manglyc_e <=> manglyc_p h2o_c + man6pglyc_c --> glyc__R_c + man6p_c man_p + pep_c --> man6p_c + pyr_c man_e <=> man_p 2mcit_c --> 2mcacn_c + h2o_c micit_c <=> pyr_c + succ_c h2o_c + oaa_c + ppcoa_c --> 2mcit_c + coa_c + h_c ACP_c + malcoa_c <=> coa_c + malACP_c cyan_c + mercppyr_c --> h_c + pyr_c + tcynt_c murein5p5p_p --> ala__D_p + murein5px4p_p murein5p5p_p --> alaala_p + murein5px3p_p murein5p5p5p_p --> 2.0 ala__D_p + murein5px4px4p_p h2o_p + murein5px4p_p --> ala__D_p + murein4px4p_p h2o_p + murein5px4px4p_p --> ala__D_p + murein4px4px4p_p h2o_p + murein5p5p_p --> ala__D_p + murein5p4p_p h2o_p + murein5p4p_p --> ala__D_p + murein4p4p_p h2o_p + murein5p3p_p --> ala__D_p + murein4p3p_p h2o_p + murein4px4p_p --> murein4p4p_p h2o_p + murein3px4p_p --> murein4p3p_p h2o_p + murein5px4p_p --> murein5p4p_p h2o_p + murein4px4px4p_p --> murein4px4p4p_p mal__L_c + nad_c <=> h_c + nadh_c + oaa_c mal__L_c + q8_c --> oaa_c + q8h2_c mal__L_c + mqn8_c --> mql8_c + oaa_c mal__L_c + nad_c --> co2_c + nadh_c + pyr_c mal__L_c + nadp_c --> co2_c + nadph_c + pyr_c 2mecdp_c + 2.0 flxr_c + h_c --> 2.0 flxso_c + h2mb4p_c + h2o_c 2p4c2me_c --> 2mecdp_c + cmp_c h_p + melib_p --> h_c + melib_c h_p + melib_c --> h_c + melib_p melib_e <=> melib_p meoh_e <=> meoh_p meoh_p <=> meoh_c 2me4p_c + ctp_c + h_c --> 4c2me_c + ppi_c atp_c + h2o_c + met__L_c --> amet_c + pi_c + ppi_c atp_c + h2o_c + met__D_p --> adp_c + h_c + met__D_c + pi_c met__D_e <=> met__D_p h2o2_c + met__L_c --> h2o_c + metsox_S__L_c h2o2_c + met__L_c --> h2o_c + metsox_R__L_c 5mthf_c + hcys__L_c --> h_c + met__L_c + thf_c atp_c + h2o_c + metsox_S__L_p --> adp_c + h_c + metsox_S__L_c + pi_c metsox_S__L_e <=> metsox_S__L_p atp_c + h2o_c + metsox_R__L_p --> adp_c + h_c + metsox_R__L_c + pi_c metsox_R__L_e <=> metsox_R__L_p metsox_S__L_c + trdrd_c --> h2o_c + met__L_c + trdox_c metsox_R__L_c + trdrd_c --> h2o_c + met__L_c + trdox_c atp_c + met__L_c + trnamet_c --> amp_c + mettrna_c + ppi_c atp_c + h2o_c + met__L_p --> adp_c + h_c + met__L_c + pi_c met__L_e <=> met__L_p 2.0 h_c + mg2_p <=> 2.0 h_p + mg2_c mg2_e <=> mg2_p mg2_p --> mg2_c atp_c + h2o_c + mg2_p --> adp_c + h_c + mg2_c + pi_c dhap_c --> mthgxl_c + pi_c h2o_c + mi1p__D_c --> inost_c + pi_c 2mcacn_c + h2o_c <=> micit_c mincyc_e <=> mincyc_p h_p + mincyc_p --> h_c + mincyc_e minohp_e --> minohp_p h2o_p + murein5px4p_p --> alaala_p + murein3px4p_p h2o_p + murein4p4p_p --> ala__D_p + murein4p3p_p h2o_p + murein5p5p_p --> alaala_p + murein5p3p_p h2o_p + murein4p3p_p --> ala__D_p + murein3p3p_p h2o_p + murein5px3p_p --> alaala_p + murein3px3p_p h2o_p + murein3px3p_p --> murein3p3p_p h2o_p + murein5px3p_p --> murein5p3p_p h2o_c + malttr_c --> glc__D_c + malt_c h2o_c + maltttr_c --> glc__D_c + malttr_c h2o_c + maltpt_c --> glc__D_c + maltttr_c h2o_c + malthx_c --> glc__D_c + maltpt_c h2o_c + malthp_c --> glc__D_c + malthx_c murein4p4p_p --> 2.0 anhgm4p_p murein4p3p_p --> anhgm3p_p + anhgm4p_p murein3p3p_p --> 2.0 anhgm3p_p murein4px4p4p_p --> anhgm4p_p + murein4px4p_p maltpt_c + pi_c <=> g1p_c + maltttr_c malthx_c + pi_c <=> g1p_c + maltpt_c malthp_c + pi_c <=> g1p_c + malthx_c h_c + mmcoa__S_c --> co2_c + ppcoa_c h_p + mmet_p --> h_c + mmet_c mmet_e <=> mmet_p succoa_c --> mmcoa__S_c h_p + mn2_c --> h_c + mn2_p mn2_p --> mn2_c h2o_c + man6p_c --> man_c + pi_c mnl_p + pep_c --> mnl1p_c + pyr_c mnl_e <=> mnl_p mana_c --> 2ddglcn_c + h2o_c h_p + mn2_p --> h_c + mn2_c mn2_e <=> mn2_p iscssh_c + moadamp_c + nadh_c --> amp_c + iscs_c + moadcosh_c + nad_c ckdo_c + lipidA_c --> cmp_c + h_c + kdolipid4_c ckdo_c + kdolipid4_c --> cmp_c + h_c + kdo2lipid4_c ckdo_c + phphhlipa_c --> cmp_c + h_c + kphphhlipa_c atp_c + h2o_c + mobd_p --> adp_c + h_c + mobd_c + pi_c mobd_e <=> mobd_p ctp_c + h_c + moco_c --> mococdp_c + ppi_c 2.0 h_c + mobd_c + mptamp_c --> amp_c + cu2_c + h2o_c + moco_c gtp_c + h_c + moco_c --> mocogdp_c + ppi_c 3mob_c + h2o_c + mlthf_c --> 2dhp_c + thf_c mal__L_c + o2_c <=> h2o2_c + oaa_c atp_c + h_c + mpt_c --> mptamp_c + ppi_c 2.0 uaagmda_c --> 2.0 h_c + murein5p5p_p + 2.0 udcpdp_c murein5p5p_p + uaagmda_c --> h_c + murein5p5p5p_p + udcpdp_c cpmp_c + cu2_c + 2.0 moadcosh_c --> 5.0 h_c + 2.0 moadcoo_c + mpt_c atp_c + h_c + moadcoo_c --> moadamp_c + ppi_c h_c + msa_c + nadph_c --> 3hpp_c + nadp_c atp_c + h2o_c + mso3_p --> adp_c + h_c + mso3_c + pi_c mso3_e <=> mso3_p 5mta_c + h2o_c --> 5mtr_c + ade_c h2o_c + methf_c <=> 10fthf_c + h_c mlthf_c + nadp_c <=> methf_c + nadph_c 2.0 h_c + mlthf_c + nadh_c --> 5mthf_c + nad_c h2o_c + mdhdhf_c --> mththf_c Nmtrp_c + h2o_c + o2_c --> fald_c + h2o2_c + trp__L_c n2o_e <=> n2o_p n2o_p <=> n2o_c acg5sa_c + h2o_c --> ac_c + glu5sa_c nac_e <=> nac_p nac_p --> nac_c h2o_c + nad_c --> amp_c + 2.0 h_c + nmn_c h_c + mqn8_c + nadh_c --> mql8_c + nad_c 4.0 h_c + nadh_c + q8_c --> 3.0 h_p + nad_c + q8h2_c 4.0 h_c + mqn8_c + nadh_c --> 3.0 h_p + mql8_c + nad_c 2dmmq8_c + 4.0 h_c + nadh_c --> 2dmmql8_c + 3.0 h_p + nad_c h_c + nadh_c + q8_c --> nad_c + q8h2_c 2dmmq8_c + h_c + nadh_c --> 2dmmql8_c + nad_c atp_c + nad_c --> adp_c + h_c + nadp_c h2o_c + nad_c --> adprib_c + h_c + ncam_c h_c + nadph_c + q8_c --> nadp_c + q8h2_c h_c + mqn8_c + nadph_c --> mql8_c + nadp_c 2dmmq8_c + h_c + nadph_c --> 2dmmql8_c + nadp_c h2o_c + nadp_c --> nad_c + pi_c atp_c + dnad_c + nh4_c --> amp_c + h_c + nad_c + ppi_c nad_c + nadph_c --> nadh_c + nadp_c atp_c + h2o_c + nac_c + prpp_c --> adp_c + nicrnt_c + pi_c + ppi_c 3.0 h_p + 2.0 na1_c --> 3.0 h_c + 2.0 na1_p 2.0 h_p + na1_c --> 2.0 h_c + na1_p h_p + na1_c --> h_c + na1_p na1_e <=> na1_p atp_c + gdp_c <=> adp_c + gtp_c atp_c + udp_c <=> adp_c + utp_c atp_c + cdp_c <=> adp_c + ctp_c atp_c + dtdp_c <=> adp_c + dttp_c atp_c + dgdp_c <=> adp_c + dgtp_c atp_c + dudp_c <=> adp_c + dutp_c atp_c + dcdp_c <=> adp_c + dctp_c atp_c + dadp_c <=> adp_c + datp_c nh4_e <=> nh4_p nh4_p <=> nh4_c h_c + nadh_c + 2.0 no_c --> h2o_c + n2o_c + nad_c atp_c + h2o_c + ni2_c --> adp_c + h_c + ni2_p + pi_c h_p + ni2_c --> h_c + ni2_p ni2_e <=> ni2_p ni2_p --> ni2_c atp_c + h2o_c + ni2_p --> adp_c + h_c + ni2_c + pi_c atp_c + h_c + nmn_c --> nad_c + ppi_c h2o_c + nmn_c --> nh4_c + nicrnt_c h2o_c + nmn_c --> h_c + ncam_c + r5p_c nmn_p --> nmn_c h2o_c + nmn_p --> h_c + ncam_c + r5p_c nmn_e <=> nmn_p h2o_c + ncam_c --> nac_c + nh4_c atp_c + h_c + nicrnt_c <=> dnad_c + ppi_c dmbzid_c + nicrnt_c --> 5prdmbz_c + h_c + nac_c 2.0 h_c + prpp_c + quln_c --> co2_c + nicrnt_c + ppi_c h_p + no2_p <=> h_c + no2_c no2_e <=> no2_p no3_p + q8h2_c --> h2o_p + no2_p + q8_c 2.0 h_c + no3_c + q8h2_c --> h2o_c + 2.0 h_p + no2_c + q8_c mql8_c + no3_p --> h2o_p + mqn8_c + no2_p 2.0 h_c + mql8_c + no3_c --> h2o_c + 2.0 h_p + mqn8_c + no2_c no2_c + no3_p --> no2_p + no3_c no3_e <=> no3_p nadh_c + 2.0 no_c + 2.0 o2_c --> h_c + nad_c + 2.0 no3_c nadph_c + 2.0 no_c + 2.0 o2_c --> h_c + nadp_c + 2.0 no3_c novbcn_e <=> novbcn_p h_p + novbcn_p --> h_c + novbcn_e no_e <=> no_p no_p <=> no_c dump_c + h2o_c --> duri_c + pi_c h2o_c + xmp_c --> pi_c + xtsn_c h2o_p + xmp_p --> pi_p + xtsn_p h2o_c + imp_c --> ins_c + pi_c h2o_p + imp_p --> ins_p + pi_p dimp_c + h2o_c --> din_c + pi_c dimp_p + h2o_p --> din_p + pi_p dump_p + h2o_p --> duri_p + pi_p h2o_c + ump_c --> pi_c + uri_c h2o_p + ump_p --> pi_p + uri_p dcmp_c + h2o_c --> dcyt_c + pi_c dcmp_p + h2o_p --> dcyt_p + pi_p cmp_c + h2o_c --> cytd_c + pi_c cmp_p + h2o_p --> cytd_p + pi_p dtmp_c + h2o_c --> pi_c + thymd_c dtmp_p + h2o_p --> pi_p + thymd_p damp_c + h2o_c --> dad_2_c + pi_c damp_p + h2o_p --> dad_2_p + pi_p amp_c + h2o_c --> adn_c + pi_c amp_p + h2o_p --> adn_p + pi_p dgmp_c + h2o_c --> dgsn_c + pi_c dgmp_p + h2o_p --> dgsn_p + pi_p gmp_c + h2o_c --> gsn_c + pi_c gmp_p + h2o_p --> gsn_p + pi_p atp_c + h2o_c --> adp_c + h_c + pi_c h2o_c + itp_c --> h_c + idp_c + pi_c ditp_c + h2o_c --> didp_c + h_c + pi_c h2o_c + xtp_c --> h_c + pi_c + xdp_c gtp_c + h2o_c --> gdp_c + h_c + pi_c gtp_p + h2o_p --> gdp_p + h_p + pi_p ctp_c + h2o_c --> cdp_c + h_c + pi_c dgtp_c + h2o_c --> dgmp_c + h_c + ppi_c ditp_c + h2o_c --> dimp_c + h_c + ppi_c h2o_c + xtp_c --> h_c + ppi_c + xmp_c gtp_c + h2o_c --> gmp_c + h_c + ppi_c dctp_c + h2o_c --> dcmp_c + h_c + ppi_c ctp_c + h2o_c --> cmp_c + h_c + ppi_c datp_c + h2o_c --> damp_c + h_c + ppi_c atp_c + h2o_c --> amp_c + h_c + ppi_c dttp_c + h2o_c --> dtmp_c + h_c + ppi_c h2o_c + utp_c --> h_c + ppi_c + ump_c h2o_c + itp_c --> h_c + imp_c + ppi_c dgtp_c + h2o_c --> dgsn_c + pppi_c gtp_c + h2o_c --> gsn_c + pppi_c 5.0 h_c + 3.0 nadh_c + no2_c --> 2.0 h2o_c + 3.0 nad_c + nh4_c 2.0 h_p + no2_p + 3.0 q8h2_c --> 2.0 h2o_p + nh4_p + 3.0 q8_c 2.0 h_p + 3.0 mql8_c + no2_p --> 2.0 h2o_p + 3.0 mqn8_c + nh4_p atp_c + h2o_c + o16a4colipa_p --> adp_c + h_c + o16a4colipa_e + pi_c colipa_p + o16a4und_p --> h_p + o16a4colipa_p + udcpdp_p 2.0 o16aund_p --> h_p + o16a2und_p + udcpdp_p o16a2und_p + o16aund_p --> h_p + o16a3und_p + udcpdp_p o16a3und_p + o16aund_p --> h_p + o16a4und_p + udcpdp_p accoa_c + ragund_c --> aragund_c + coa_c o16aund_c --> o16aund_p garagund_c + udpgalfur_c --> gfgaragund_c + h_c + udp_c aragund_c + udpg_c --> garagund_c + h_c + udp_c gfgaragund_c + udpg_c --> h_c + o16aund_c + udp_c o2s_e <=> o2s_p o2_e <=> o2_p o2_p <=> o2_c h_c + oaa_c --> co2_c + pyr_c 2obut_c + coa_c --> for_c + ppcoa_c cbp_c + orn_c <=> citr__L_c + h_c + pi_c ocdca_e --> ocdca_p ocdcea_e --> ocdcea_p octa_e <=> octa_p frdp_c + 5.0 ipdp_c --> octdp_c + 5.0 ppi_c atp_c + h_c + octa_c --> amp_c + octapb_c + ppi_c hgmeACP_c --> egmeACP_c + h2o_c h_c + nadph_c + ogmeACP_c --> hgmeACP_c + nadp_c h_c + malACP_c + malcoame_c --> co2_c + coa_c + ogmeACP_c glu__L_c + ohpb_c <=> akg_c + phthr_c 2ohph_c + amet_c --> 2omph_c + ahcys_c + h_c 2ombzl_c + amet_c --> 2ommbl_c + ahcys_c + h_c 3c4mop_c + h_c --> 4mop_c + co2_c 2ommbl_c + 0.5 o2_c --> 2omhmbl_c 2ommbl_c + 2.0 atp_c + 3.0 h2o_c + nad_c --> 2omhmbl_c + 2.0 adp_c + 3.0 h_c + nadh_c + 2.0 pi_c h_c + orot5p_c --> co2_c + ump_c 2omph_c + 0.5 o2_c --> 2ombzl_c 2omph_c + 2.0 atp_c + 3.0 h2o_c + nad_c --> 2ombzl_c + 2.0 adp_c + 3.0 h_c + nadh_c + 2.0 pi_c h2o_c + op4en_c --> 4h2opntn_c 3ophb_c + h_c --> 2oph_c + co2_c 2oph_c + 0.5 o2_c --> 2ohph_c 2oph_c + 2.0 atp_c + 3.0 h2o_c + nad_c --> 2ohph_c + 2.0 adp_c + 3.0 h_c + nadh_c + 2.0 pi_c hpmeACP_c --> epmeACP_c + h2o_c h_c + nadph_c + opmeACP_c --> hpmeACP_c + nadp_c gmeACP_c + h_c + malACP_c --> ACP_c + co2_c + opmeACP_c h_c + orn_c --> co2_c + ptrc_c atp_c + h2o_c + orn_p --> adp_c + h_c + orn_c + pi_c orn_e <=> orn_p 2.0 h_p + orot_p --> 2.0 h_c + orot_c orot_e <=> orot_p orot5p_c + ppi_c <=> orot_c + prpp_c oxur_c + pi_c --> cbp_c + oxam_c h_c + oxalcoa_c --> co2_c + forcoa_c 2oxpaccoa_c + 2.0 h2o_c + nadp_c --> 3oxdhscoa_c + 2.0 h_c + nadph_c 3oxdhscoa_c + coa_c --> 23dhacoa_c + accoa_c 1pyr5c_c + 2.0 h2o_c + nad_c --> glu__L_c + h_c + nadh_c 1pyr5c_c + 2.0 h_c + nadph_c --> nadp_c + pro__L_c atp_c + h2o_c + pa120_c --> adp_c + h_c + pa120_p + pi_c atp_c + h2o_c + pa140_c --> adp_c + h_c + pa140_p + pi_c atp_c + h2o_c + pa141_c --> adp_c + h_c + pa141_p + pi_c atp_c + h2o_c + pa160_c --> adp_c + h_c + pa160_p + pi_c atp_c + h2o_c + pa161_c --> adp_c + h_c + pa161_p + pi_c atp_c + h2o_c + pa180_c --> adp_c + h_c + pa180_p + pi_c atp_c + h2o_c + pa181_c --> adp_c + h_c + pa181_p + pi_c h_p + pacald_p <=> h_c + pacald_c pacald_e <=> pacald_p h_c + nadph_c + o2_c + phaccoa_c --> h2o_c + nadp_c + rephaccoa_c atp_c + coa_c + pac_c --> amp_c + phaccoa_c + ppi_c ala_B_c + atp_c + pant__R_c --> amp_c + h_c + pnto__R_c + ppi_c h2o_c + pa120_c --> 12dgr120_c + pi_c h2o_p + pa120_p --> 12dgr120_p + pi_p h2o_c + pa140_c --> 12dgr140_c + pi_c h2o_p + pa140_p --> 12dgr140_p + pi_p h2o_c + pa141_c --> 12dgr141_c + pi_c h2o_p + pa141_p --> 12dgr141_p + pi_p h2o_c + pa160_c --> 12dgr160_c + pi_c h2o_p + pa160_p --> 12dgr160_p + pi_p h2o_c + pa161_c --> 12dgr161_c + pi_c h2o_p + pa161_p --> 12dgr161_p + pi_p h2o_c + pa180_c --> 12dgr180_c + pi_c h2o_p + pa180_p --> 12dgr180_p + pi_p h2o_c + pa181_c --> 12dgr181_c + pi_c h2o_p + pa181_p --> 12dgr181_p + pi_p udcpp_c + ugmda_c --> uagmda_c + ump_c paps_c + trdrd_c --> 2.0 h_c + pap_c + so3_c + trdox_c grxrd_c + paps_c --> grxox_c + 2.0 h_c + pap_c + so3_c camp_c + h2o_c --> amp_c + h_c 35cgmp_c + h2o_c --> gmp_c + h_c coa_c + nad_c + pyr_c --> accoa_c + co2_c + nadh_c nad_c + pdx5p_c --> h_c + nadh_c + pydx5p_c o2_c + pdx5p_c --> h2o2_c + pydx5p_c dxyl5p_c + nad_c + phthr_c --> co2_c + 2.0 h2o_c + h_c + nadh_c + pdx5p_c + pi_c h2o_c + pdx5p_c --> pi_c + pydxn_c atp_c + h2o_c + pe120_c --> adp_c + h_c + pe120_p + pi_c atp_c + h2o_c + pe140_c --> adp_c + h_c + pe140_p + pi_c atp_c + h2o_c + pe141_c --> adp_c + h_c + pe141_p + pi_c atp_c + h2o_c + pe160_c --> adp_c + h_c + pe160_p + pi_c atp_c + h2o_c + pe161_c --> adp_c + h_c + pe161_p + pi_c atp_c + h2o_c + pe180_c --> adp_c + h_c + pe180_p + pi_c atp_c + h2o_c + pe181_c --> adp_c + h_c + pe181_p + pi_c h2o_p + o2_p + peamn_p --> h2o2_p + nh4_p + pacald_p peamn_e <=> peamn_p 4per_c + nad_c <=> h_c + nadh_c + ohpb_c lipa_p + pe161_p --> 12dgr161_p + enlipa_p lipa_p + pe181_p --> 12dgr181_p + enlipa_p atp_c + f6p_c --> adp_c + fdp_c + h_c atp_c + tag6p__D_c --> adp_c + h_c + tagdp__D_c atp_c + s7p_c --> adp_c + h_c + s17bp_c coa_c + pyr_c --> accoa_c + for_c atp_c + h2o_c + pg120_c --> adp_c + h_c + pg120_p + pi_c atp_c + h2o_c + pg140_c --> adp_c + h_c + pg140_p + pi_c atp_c + h2o_c + pg141_c --> adp_c + h_c + pg141_p + pi_c atp_c + h2o_c + pg160_c --> adp_c + h_c + pg160_p + pi_c atp_c + h2o_c + pg161_c --> adp_c + h_c + pg161_p + pi_c atp_c + h2o_c + pg180_c --> adp_c + h_c + pg180_p + pi_c atp_c + h2o_c + pg181_c --> adp_c + h_c + pg181_p + pi_c gam1p_c <=> gam6p_c 3pg_c + nad_c --> 3php_c + h_c + nadh_c g6p_c <=> f6p_c 3pg_c + atp_c <=> 13dpg_c + adp_c 6pgl_c + h2o_c --> 6pgc_c + h_c 2pglyc_c + h2o_c --> glyclt_c + pi_c 2pg_c <=> 3pg_c g1p_c <=> g6p_c atp_c + h2o_c + pgp120_c --> adp_c + h_c + pgp120_p + pi_c atp_c + h2o_c + pgp140_c --> adp_c + h_c + pgp140_p + pi_c atp_c + h2o_c + pgp141_c --> adp_c + h_c + pgp141_p + pi_c atp_c + h2o_c + pgp160_c --> adp_c + h_c + pgp160_p + pi_c atp_c + h2o_c + pgp161_c --> adp_c + h_c + pgp161_p + pi_c atp_c + h2o_c + pgp180_c --> adp_c + h_c + pgp180_p + pi_c atp_c + h2o_c + pgp181_c --> adp_c + h_c + pgp181_p + pi_c h2o_c + pgp120_c --> pg120_c + pi_c h2o_p + pgp120_p --> pg120_p + pi_p h2o_c + pgp140_c --> pg140_c + pi_c h2o_p + pgp140_p --> pg140_p + pi_p h2o_c + pgp141_c --> pg141_c + pi_c h2o_p + pgp141_p --> pg141_p + pi_p h2o_c + pgp160_c --> pg160_c + pi_c h2o_p + pgp160_p --> pg160_p + pi_p h2o_c + pgp161_c --> pg161_c + pi_c h2o_p + pgp161_p --> pg161_p + pi_p h2o_c + pgp180_c --> pg180_c + pi_c h2o_p + pgp180_p --> pg180_p + pi_p h2o_c + pgp181_c --> pg181_c + pi_c h2o_p + pgp181_p --> pg181_p + pi_p cdpdddecg_c + glyc3p_c --> cmp_c + h_c + pgp120_c cdpdtdecg_c + glyc3p_c --> cmp_c + h_c + pgp140_c cdpdtdec7eg_c + glyc3p_c --> cmp_c + h_c + pgp141_c cdpdhdecg_c + glyc3p_c --> cmp_c + h_c + pgp160_c cdpdhdec9eg_c + glyc3p_c --> cmp_c + h_c + pgp161_c cdpdodecg_c + glyc3p_c --> cmp_c + h_c + pgp180_c cdpdodec11eg_c + glyc3p_c --> cmp_c + h_c + pgp181_c atp_c + h2o_c + pheme_c --> adp_c + h_c + pheme_p + pi_c pheme_p --> pheme_e akg_c + phe__L_c <=> glu__L_c + phpyr_c atp_c + phe__L_c + trnaphe_c --> amp_c + phetrna_c + ppi_c h_p + phe__L_p <=> h_c + phe__L_c phe__L_e <=> phe__L_p 6.0 h2o_p + minohp_p --> inost_p + 6.0 pi_p h_p + pi_p <=> h_c + pi_c pi_e <=> pi_p atp_c + h2o_c + pi_p --> adp_c + h_c + 2.0 pi_c h2o_p + pa120_p --> 2ddecg3p_p + ddca_p h2o_p + pa140_p --> 2tdecg3p_p + ttdca_p h2o_p + pa141_p --> 2tdec7eg3p_p + ttdcea_p h2o_p + pa160_p --> 2hdecg3p_p + hdca_p h2o_p + pa161_p --> 2hdec9eg3p_p + hdcea_p h2o_p + pa180_p --> 2odecg3p_p + ocdca_p h2o_p + pa181_p --> 2odec11eg3p_p + ocdcea_p h2o_p + pe120_p --> 2agpe120_p + ddca_p + h_p h2o_p + pe140_p --> 2agpe140_p + h_p + ttdca_p h2o_p + pe141_p --> 2agpe141_p + h_p + ttdcea_p h2o_p + pe160_p --> 2agpe160_p + h_p + hdca_p h2o_p + pe161_p --> 2agpe161_p + h_p + hdcea_p h2o_p + pe180_p --> 2agpe180_p + h_p + ocdca_p h2o_p + pe181_p --> 2agpe181_p + h_p + ocdcea_p h2o_p + pg120_p --> 2agpg120_p + ddca_p + h_p h2o_p + pg140_p --> 2agpg140_p + h_p + ttdca_p h2o_p + pg141_p --> 2agpg141_p + h_p + ttdcea_p h2o_p + pg160_p --> 2agpg160_p + h_p + hdca_p h2o_p + pg161_p --> 2agpg161_p + h_p + hdcea_p h2o_p + pg180_p --> 2agpg180_p + h_p + ocdca_p h2o_p + pg181_p --> 2agpg181_p + h_p + ocdcea_p h2o_p + pa120_p --> 1ddecg3p_p + ddca_p + h_p h2o_p + pa140_p --> 1tdecg3p_p + h_p + ttdca_p h2o_p + pa141_p --> 1tdec7eg3p_p + h_p + ttdcea_p h2o_p + pa160_p --> 1hdecg3p_p + h_p + hdca_p h2o_p + pa161_p --> 1hdec9eg3p_p + h_p + hdcea_p h2o_p + pa180_p --> 1odecg3p_p + h_p + ocdca_p h2o_p + pa181_p --> 1odec11eg3p_p + h_p + ocdcea_p h2o_p + pe120_p --> 1agpe120_p + ddca_p + h_p h2o_p + pe140_p --> 1agpe140_p + h_p + ttdca_p h2o_p + pe141_p --> 1agpe141_p + h_p + ttdcea_p h2o_p + pe160_p --> 1agpe160_p + h_p + hdca_p h2o_p + pe161_p --> 1agpe161_p + h_p + hdcea_p h2o_p + pe180_p --> 1agpe180_p + h_p + ocdca_p h2o_p + pe181_p --> 1agpe181_p + h_p + ocdcea_p h2o_p + pg120_p --> 1agpg120_p + ddca_p + h_p h2o_p + pg140_p --> 1agpg140_p + h_p + ttdca_p h2o_p + pg141_p --> 1agpg141_p + h_p + ttdcea_p h2o_p + pg160_p --> 1agpg160_p + h_p + hdca_p h2o_p + pg161_p --> 1agpg161_p + h_p + hdcea_p h2o_p + pg180_p --> 1agpg180_p + h_p + ocdca_p h2o_p + pg181_p --> 1agpg181_p + h_p + ocdcea_p man1p_c <=> man6p_c 5aprbu_c + h2o_c --> 4r5au_c + pi_c h2o_c + pmeACP_c --> meoh_c + pimACP_c 4ampm_c + atp_c --> 2mahmp_c + adp_c atp_c + pnto__R_c --> 4ppan_c + adp_c + h_c na1_p + pnto__R_p --> na1_c + pnto__R_c pnto__R_e <=> pnto__R_p nadh_c + poaac_c --> 3amac_c + h2o_c + nad_c coa_c + 2.0 flxso_c + pyr_c <=> accoa_c + co2_c + 2.0 flxr_c + h_c h2o_c + pyr_c + q8_c --> ac_c + co2_c + q8h2_c h2o_c + ppi_c --> h_c + 2.0 pi_c h2o_c + pppi_c --> h_c + pi_c + ppi_c adp_c + ppap_c <=> atp_c + ppa_c ppal_e <=> ppal_p ppal_c <=> ppal_p na1_p + ppa_p --> na1_c + ppa_c ppa_e <=> ppa_p 2.0 5aop_c --> 2.0 h2o_c + h_c + ppbng_c co2_c + h2o_c + pep_c --> h_c + oaa_c + pi_c 4ppcys_c + h_c --> co2_c + pan4p_c atp_c + oaa_c --> adp_c + co2_c + pep_c ppcoa_c + succ_c --> ppa_c + succoa_c h2o_c + ppgpp_c --> gdp_c + ppi_c atp_c + ppi_c <=> adp_c + pppi_c atp_c + pi_c <=> adp_c + ppi_c r1p_c <=> r5p_c 2dr1p_c <=> 2dr5p_c 4ppan_c + ctp_c + cys__L_c --> 4ppcys_c + cmp_c + h_c + ppi_c nad_c + pphn_c --> 34hpp_c + co2_c + nadh_c h_c + pphn_c --> co2_c + h2o_c + phpyr_c 1.5 o2_c + pppg9_c --> 3.0 h2o_c + ppp9_c 3.0 fum_c + pppg9_c --> ppp9_c + 3.0 succ_c h_c + nadh_c + o2_c + pppn_c --> cechddd_c + nad_c h_p + pppn_p <=> h_c + pppn_c pppn_e <=> pppn_p atp_c + h2o_c + pyr_c --> amp_c + 2.0 h_c + pep_c + pi_c h2o_p + ppt_p --> h2_p + pi_p ppt_e <=> ppt_p atp_c + gly_c + pram_c <=> adp_c + gar_c + h_c + pi_c atp_c + fpram_c --> adp_c + air_c + 2.0 h_c + pi_c pran_c --> 2cpr5p_c h2o_c + prbamp_c --> prfp_c 5aizc_c + asp__L_c + atp_c --> 25aics_c + adp_c + h_c + pi_c h2o_c + prbatp_c --> h_c + ppi_c + prbamp_c atp_c + fgam_c + gln__L_c + h2o_c --> adp_c + fpram_c + glu__L_c + h_c + pi_c prfp_c <=> prlp_c fad_c + pro__L_c --> 1pyr5c_c + fadh2_c + h_c atp_c + h2o_c + progly_p --> adp_c + h_c + pi_c + progly_c progly_e <=> progly_p atp_c + pro__L_c + trnapro_c --> amp_c + ppi_c + protrna_c atp_c + h2o_c + pro__L_p --> adp_c + h_c + pi_c + pro__L_c h_p + pro__L_p <=> h_c + pro__L_c na1_p + pro__L_p --> na1_c + pro__L_c pro__L_e <=> pro__L_p atp_c + r5p_c <=> amp_c + h_c + prpp_c h_p + psclys_p --> h_c + psclys_c psclys_e <=> psclys_p pep_c + skm5p_c <=> 3psme_c + pi_c h_c + ps120_c --> co2_c + pe120_c h_c + ps140_c --> co2_c + pe140_c h_c + ps141_c --> co2_c + pe141_c h_c + ps160_c --> co2_c + pe160_c h_c + ps161_c --> co2_c + pe161_c h_c + ps180_c --> co2_c + pe180_c h_c + ps181_c --> co2_c + pe181_c 3php_c + glu__L_c --> akg_c + pser__L_c pser__L_e <=> pser__L_p h2o_c + pser__L_c --> pi_c + ser__L_c h2o_p + pser__L_p --> pi_p + ser__L_p cdpdddecg_c + ser__L_c --> cmp_c + h_c + ps120_c cdpdtdecg_c + ser__L_c --> cmp_c + h_c + ps140_c cdpdtdec7eg_c + ser__L_c --> cmp_c + h_c + ps141_c cdpdhdecg_c + ser__L_c --> cmp_c + h_c + ps160_c cdpdhdec9eg_c + ser__L_c --> cmp_c + h_c + ps161_c cdpdodecg_c + ser__L_c --> cmp_c + h_c + ps180_c cdpdodec11eg_c + ser__L_c --> cmp_c + h_c + ps181_c pi_c + ppcoa_c --> coa_c + ppap_c accoa_c + pi_c <=> actp_c + coa_c h2o_p + thrp_p --> pi_p + thr__L_p atp_c + h_c + pan4p_c --> dpcoa_c + ppi_c orn_c + ptrc_p <=> orn_p + ptrc_c akg_c + ptrc_c --> 4abutn_c + glu__L_c atp_c + h2o_c + ptrc_p --> adp_c + h_c + pi_c + ptrc_c h_p + ptrc_p --> h_c + ptrc_c ptrc_e <=> ptrc_p adn_c + pi_c <=> ade_c + r1p_c dad_2_c + pi_c <=> 2dr1p_c + ade_c gsn_c + pi_c <=> gua_c + r1p_c dgsn_c + pi_c <=> 2dr1p_c + gua_c ins_c + pi_c <=> hxan_c + r1p_c din_c + pi_c <=> 2dr1p_c + hxan_c pi_c + xtsn_c <=> r1p_c + xan_c h2o_c + o2_c + pyam5p_c --> h2o2_c + nh4_c + pydx5p_c atp_c + pydam_c --> adp_c + h_c + pyam5p_c pydam_e <=> pydam_p pydam_p --> pydam_c atp_c + pydx_c --> adp_c + h_c + pydx5p_c atp_c + pydxn_c --> adp_c + h_c + pdx5p_c pydxn_e <=> pydxn_p pydxn_p --> pydxn_c h2o_c + pydx5p_c --> pi_c + pydx_c pydx_e <=> pydx_p pydx_p --> pydx_c adp_c + h_c + pep_c --> atp_c + pyr_c pi_c + uri_c <=> r1p_c + ura_c h_c + nadh_c + o2_c + ura_c --> nad_c + uracp_c h_p + pyr_p <=> h_c + pyr_c pyr_e <=> pyr_p 2.0 o2_c + q8h2_c --> 2.0 h_c + 2.0 o2s_c + q8_c mql8_c + 2.0 o2_c --> 2.0 h_c + mqn8_c + 2.0 o2s_c quin_e <=> quin_p quin_p <=> quin_c nad_c + quin_c <=> 3dhq_c + 2.0 h_c + nadh_c dhap_c + iasp_c --> 2.0 h2o_c + pi_c + quln_c atp_c + r15bp_c --> adp_c + prpp_c atp_c + r1p_c --> adp_c + h_c + r15bp_c h2o_c + r5p_c --> pi_c + rib__D_c h2o_p + r5p_p --> pi_p + rib__D_p r5p_e <=> r5p_p atp_c + ribflv_c --> adp_c + fmn_c + h_c 4r5au_c + db4p_c --> dmlz_c + 2.0 h2o_c + pi_c 2.0 dmlz_c --> 4r5au_c + ribflv_c atp_c + rib__D_c --> adp_c + h_c + r5p_c atp_c + rbl__L_c --> adp_c + h_c + ru5p__L_c ru5p__L_c <=> xu5p__D_c rephaccoa_c <=> 2oxpaccoa_c rfamp_e <=> rfamp_p h_p + rfamp_p --> h_c + rfamp_e dtdprmn_c + kphphhlipa_c --> dtdp_c + h_c + icolipa_c rhcys_c --> dhptd_c + hcys__L_c atp_c + h2o_c + rib__D_p --> adp_c + h_c + pi_c + rib__D_c rib__D_e <=> rib__D_p rmn_c <=> rml_c atp_c + rml_c --> adp_c + h_c + rml1p_c rmn_e <=> rmn_p h_p + rmn_p --> h_c + rmn_c rml1p_c <=> dhap_c + lald__L_c adp_c + trdrd_c --> dadp_c + h2o_c + trdox_c adp_c + grxrd_c --> dadp_c + grxox_c + h2o_c gdp_c + trdrd_c --> dgdp_c + h2o_c + trdox_c gdp_c + grxrd_c --> dgdp_c + grxox_c + h2o_c cdp_c + trdrd_c --> dcdp_c + h2o_c + trdox_c cdp_c + grxrd_c --> dcdp_c + grxox_c + h2o_c trdrd_c + udp_c --> dudp_c + h2o_c + trdox_c grxrd_c + udp_c --> dudp_c + grxox_c + h2o_c atp_c + 2.0 flxr_c + 2.0 h_c --> datp_c + 2.0 flxso_c + h2o_c 2.0 flxr_c + gtp_c + 2.0 h_c --> dgtp_c + 2.0 flxso_c + h2o_c ctp_c + 2.0 flxr_c + 2.0 h_c --> dctp_c + 2.0 flxso_c + h2o_c 2.0 flxr_c + 2.0 h_c + utp_c --> dutp_c + 2.0 flxso_c + h2o_c ru5p__D_c <=> xu5p__D_c r5p_c <=> ru5p__D_c 5prdmbz_c + h2o_c --> pi_c + rdmbzi_c 2fe1s_c + atp_c + h2o_c + sufbcd_c + sufsesh_c --> adp_c + 5.0 h_c + pi_c + sufbcd_2fe2s_c + sufse_c atp_c + fadh2_c + 2.0 fe2_c + h2o_c + sufbcd_c + 2.0 sufsesh_c --> adp_c + fad_c + 7.0 h_c + pi_c + sufbcd_2fe2s_c + 2.0 sufse_c atp_c + fadh2_c + 2.0 fe2_c + h2o_c + sufbcd_2fe2s_c + 2.0 sufsesh_c --> adp_c + fad_c + 7.0 h_c + pi_c + sufbcd_2fe2s2_c + 2.0 sufse_c 4.0 h_c + sufbcd_2fe2s_c --> 2fe2s_c + sufbcd_c fadh2_c + 2.0 h_c + sufbcd_2fe2s2_c --> fad_c + sufbcd_4fe4s_c 4.0 h_c + sufbcd_4fe4s_c --> 4fe4s_c + sufbcd_c s7p_c --> gmhep7p_c 2.0 h2o_c + 2.0 h_c + sucarg_c --> co2_c + 2.0 nh4_c + sucorn_c atp_c + gtp_c + h2o_c + so4_c --> aps_c + gdp_c + pi_c + ppi_c h2o_c + o2_c + sarcs_c --> fald_c + gly_c + h2o2_c nad_c + sbt6p_c <=> f6p_c + h_c + nadh_c pep_c + sbt__D_p --> pyr_c + sbt6p_c sbt__D_e <=> sbt__D_p cys__L_c + sufse_c --> ala__L_c + sufsesh_c h2o_c + sl26da_c --> 26dap_LL_c + succ_c akg_c + sl26da_c <=> glu__L_c + sl2a6o_c selnp_c + sertrna_sec_c --> h_c + pi_c + sectrna_c 4.0 gthrd_c + 2.0 h_c + slnt_c --> dgslnt_c + gthox_c + 3.0 h2o_c dgslnt_c + h_c + nadph_c --> gslnt_c + gthrd_c + nadp_c gslnt_c + nadph_c --> gthrd_c + nadp_c + seln_c atp_c + h2o_c + seln_c --> amp_c + pi_c + selnp_c mql8_c + sel_c --> h2o_c + mqn8_c + slnt_c sel_e <=> sel_p 2.0 h_p + sel_p --> 2.0 h_c + sel_c akg_c + h_c + ichor_c --> 2sephchc_c + co2_c atp_c + h_c + ser__L_c <=> ppi_c + seramp_c accoa_c + ser__L_c <=> acser_c + coa_c ser__D_c --> nh4_c + pyr_c ser__L_c --> nh4_c + pyr_c atp_c + ser__L_c + trnaser_c --> amp_c + ppi_c + sertrna_c atp_c + ser__L_c + trnasecys_c --> amp_c + ppi_c + sertrna_sec_c h_p + ser__L_p <=> h_c + ser__L_c na1_p + ser__L_p --> na1_c + ser__L_c ser__L_e <=> ser__L_p Sfglutth_c + h2o_c --> for_c + gthrd_c + h_c h2o_c + sucglu_c --> glu__L_c + succ_c h2o_c + nad_c + sucgsa_c --> 2.0 h_c + nadh_c + sucglu_c 2sephchc_c --> 2shchc_c + pyr_c dscl_c + nad_c --> h_c + nadh_c + scl_c fe2_c + scl_c --> 3.0 h_c + sheme_c 3dhsk_c + h_c + nadph_c <=> nadp_c + skm_c atp_c + skm_c --> adp_c + h_c + skm5p_c cys__L_c + suchms_c --> cyst__L_c + h_c + succ_c h_p + skm_p --> h_c + skm_c skm_e <=> skm_p slnt_e <=> slnt_p h_p + slnt_p --> h_c + slnt_c so2_e <=> so2_p so2_p <=> so2_c so3_e <=> so3_p h_p + so4_p --> h_c + so4_c so4_e <=> so4_p akg_c + sucorn_c --> glu__L_c + sucgsa_c accoa_c + spmd_c --> N1aspmd_c + coa_c + h_c accoa_c + spmd_c --> coa_c + h_c + n8aspmd_c atp_c + h2o_c + spmd_p --> adp_c + h_c + pi_c + spmd_c h_p + spmd_c --> h_c + spmd_p spmd_e <=> spmd_p ametam_c + ptrc_c --> 5mta_c + h_c + spmd_c 2.0 h_c + 2.0 o2s_c --> h2o2_c + o2_c 2.0 h_p + 2.0 o2s_p --> h2o2_p + o2_p h2o_c + nad_c + sucsal_c --> 2.0 h_c + nadh_c + succ_c h2o_c + nadp_c + sucsal_c --> 2.0 h_c + nadph_c + succ_c asp__L_p + succ_c --> asp__L_c + succ_p atp_c + coa_c + sucbz_c --> amp_c + ppi_c + sbzcoa_c 2shchc_c --> h2o_c + sucbz_c 2.0 h_p + succ_p --> 2.0 h_c + succ_c 3.0 h_p + succ_p --> 3.0 h_c + succ_c h_p + succ_c --> h_c + succ_p succ_e <=> succ_p q8_c + succ_c --> fum_c + q8h2_c fum_p + succ_c --> fum_c + succ_p mal__L_p + succ_c --> mal__L_c + succ_p atp_c + coa_c + succ_c <=> adp_c + pi_c + succoa_c sucr_e <=> sucr_p succ_c + tartr__D_p --> succ_p + tartr__D_c pep_c + sucr_p --> pyr_c + suc6p_c atp_c + h2o_c + sulfac_p --> adp_c + h_c + pi_c + sulfac_c sulfac_e <=> sulfac_p 5.0 h_c + 3.0 nadph_c + so3_c --> 3.0 h2o_c + h2s_c + 3.0 nadp_c atp_c + h2o_c + so4_p --> adp_c + h_c + pi_c + so4_c tdec2eACP_c <=> cdec3eACP_c altrn_c + nad_c <=> h_c + nadh_c + tagur_c g3p_c + s7p_c <=> e4p_c + f6p_c tartr__L_c --> h2o_c + oaa_c tartr__D_e <=> tartr__D_p succ_c + tartr__L_p <=> succ_p + tartr__L_c tartr__L_e <=> tartr__L_p 3.0 h_p + tartr__D_p --> 3.0 h_c + tartr__D_c akg_c + o2_c + taur_c --> aacald_c + co2_c + h_c + so3_c + succ_c atp_c + h2o_c + taur_p --> adp_c + h_c + pi_c + taur_c taur_e <=> taur_p tcynt_e <=> tcynt_p h2o_c + thmpp_c --> h_c + pi_c + thmmp_c accoa_c + dtdp4addg_c --> coa_c + dtdp4aaddg_c + h_c dtdp4d6dg_c + glu__L_c --> akg_c + dtdp4addg_c dtdp4d6dg_c --> dtdp4d6dm_c dtdp4d6dm_c + h_c + nadph_c --> dtdprmn_c + nadp_c dtdpglu_c --> dtdp4d6dg_c + h2o_c atp_c + lipidAds_c --> adp_c + h_c + lipidA_c dsbcox_p + dsbdrd_c --> dsbcrd_p + dsbdox_c dsbdrd_c + dsbgox_p --> dsbdox_c + dsbgrd_p tagdp__D_c <=> dhap_c + g3p_c 2.0 h_p + nadh_c + nadp_c --> 2.0 h_c + nad_c + nadph_c h2o_c + succoa_c + thdp_c --> coa_c + sl2a6o_c h2o_c + methf_c --> 5fthf_c + h_c h2o2_c + trdrd_c --> 2.0 h2o_c + trdox_c h_p + thymd_p --> h_c + thymd_c h_p + thymd_p <=> h_c + thymd_c thymd_e <=> thymd_p atp_c + h2o_c + thm_p --> adp_c + h_c + pi_c + thm_c thm_e <=> thm_p athr__L_c --> acald_c + gly_c thr__L_c --> acald_c + gly_c nad_c + thr__L_c --> 2aobut_c + h_c + nadh_c thr__L_c --> 2obut_c + nh4_c thrp_e <=> thrp_p h2o_c + phom_c --> pi_c + thr__L_c atp_c + thr__L_c + trnathr_c --> amp_c + ppi_c + thrtrna_c atp_c + h2o_c + thr__L_p --> adp_c + h_c + pi_c + thr__L_c h_p + thr__L_c --> h_c + thr__L_p h_p + thr__L_p <=> h_c + thr__L_c na1_p + thr__L_p --> na1_c + thr__L_c thr__L_e <=> thr__L_p h_p + thym_c --> h_c + thym_p thym_e <=> thym_p atp_c + dhgly_c + dxyl5p_c + h_c + iscssh_c + nadph_c --> 4mpetz_c + amp_c + co2_c + 2.0 h2o_c + iscs_c + nadp_c + ppi_c r5p_c + xu5p__D_c <=> g3p_c + s7p_c e4p_c + xu5p__D_c <=> f6p_c + g3p_c h_c + mql8_c + tmao_c --> h2o_c + mqn8_c + tma_c h_p + mql8_c + tmao_p --> h2o_p + mqn8_c + tma_p 2dmmql8_c + h_c + tmao_c --> 2dmmq8_c + h2o_c + tma_c 2dmmql8_c + h_p + tmao_p --> 2dmmq8_c + h2o_p + tma_p tmao_e <=> tmao_p tma_e <=> tma_p atp_c + thymd_c --> adp_c + dtmp_c + h_c pi_c + thymd_c <=> 2dr1p_c + thym_c dump_c + mlthf_c --> dhf_c + dtmp_c atp_c + thm_c --> adp_c + h_c + thmmp_c atp_c + thmmp_c --> adp_c + thmpp_c 2mahmp_c + 4mpetz_c + h_c --> ppi_c + thmmp_c dhap_c <=> g3p_c atp_c + dpcoa_c --> 2tpr3dpcoa_c + ade_c h_c + nadph_c + trdox_c --> nadp_c + trdrd_c h2o_c + tre6p_c --> g6p_c + glc__D_c h2o_c + tre6p_c --> pi_c + tre_c g6p_c + udpg_c --> h_c + tre6p_c + udp_c h2o_c + tre_c --> 2.0 glc__D_c h2o_p + tre_p --> 2.0 glc__D_p pep_c + tre_p --> pyr_c + tre6p_c tre_e <=> tre_p h2o_c + trp__L_c <=> indole_c + nh4_c + pyr_c 3ig3p_c + ser__L_c --> g3p_c + h2o_c + trp__L_c indole_c + ser__L_c --> h2o_c + trp__L_c 3ig3p_c --> g3p_c + indole_c atp_c + trnatrp_c + trp__L_c --> amp_c + ppi_c + trptrna_c h_p + trp__L_p <=> h_c + trp__L_c trp__L_e <=> trp__L_p 2h3oppan_c + h_c + nadh_c <=> glyc__R_c + nad_c atp_c + h2o_c + tsul_p --> adp_c + h_c + pi_c + tsul_c tsul_e <=> tsul_p ttdca_e --> ttdca_p ttdcea_e --> ttdcea_p ttrcyc_e <=> ttrcyc_p h_p + ttrcyc_p --> h_c + ttrcyc_e atp_c + h2o_c + tungs_p --> adp_c + h_c + pi_c + tungs_c tungs_e <=> tungs_p tym_e <=> tym_p amet_c + nadph_c + tyr__L_c --> 4crsol_c + dad_5_c + dhgly_c + h_c + met__L_c + nadp_c h2o_p + o2_p + tym_p --> 4hoxpacd_p + h2o2_p + nh4_p h2o_p + tyrp_p --> pi_p + tyr__L_p tyrp_e <=> tyrp_p akg_c + tyr__L_c <=> 34hpp_c + glu__L_c atp_c + trnatyr_c + tyr__L_c --> amp_c + ppi_c + tyrtrna_c h_p + tyr__L_p <=> h_c + tyr__L_c tyr__L_e <=> tyr__L_p adp_c + h_c + thmpp_c --> athtp_c + pi_c 3hmrsACP_c + u3hga_c --> ACP_c + h_c + u23ga_c 26dap__M_c + atp_c + uamag_c --> adp_c + h_c + pi_c + ugmd_c h2o_p + udpacgal_p --> acgal1p_p + 2.0 h_p + ump_p h2o_p + uacgam_p --> acgam1p_p + 2.0 h_p + ump_p uacgam_e <=> uacgam_p h2o_c + 2.0 nad_c + uacmam_c --> 3.0 h_c + 2.0 nadh_c + uacmamu_c uacgam_c <=> uacmam_c 3hmrsACP_c + uacgam_c <=> ACP_c + u3aga_c pep_c + uacgam_c --> pi_c + uaccg_c acgam1p_c + h_c + utp_c --> ppi_c + uacgam_c uacgam_c + uagmda_c --> h_c + uaagmda_c + udp_c atp_c + glu__D_c + uama_c --> adp_c + h_c + pi_c + uamag_c ala__L_c + atp_c + uamr_c --> adp_c + h_c + pi_c + uama_c h_c + nadph_c + uaccg_c --> nadp_c + uamr_c h2o_c + udcpdp_c --> h_c + pi_c + udcpp_c frdp_c + 8.0 ipdp_c --> 8.0 ppi_c + udcpdp_c h2o_p + udcpdp_p --> h_p + pi_p + udcpp_p udcpp_p --> udcpp_c udpacgal_e <=> udpacgal_p udpg_c <=> udpgal_c udpgal_c --> udpgalfur_c h2o_p + udpgal_p --> gal1p_p + 2.0 h_p + ump_p udpgal_e <=> udpgal_p h2o_c + 2.0 nad_c + udpg_c --> 3.0 h_c + 2.0 nadh_c + udpglcur_c nad_c + udpglcur_c --> co2_c + nadh_c + udpLa4o_c udpglcur_e <=> udpglcur_p h2o_p + udpg_p --> g1p_p + 2.0 h_p + ump_p udpg_e <=> udpg_p glu__L_c + udpLa4o_c <=> akg_c + udpLa4n_c h2o_p + udpglcur_p --> glcur1p_p + 2.0 h_p + ump_p gal1p_c + udpg_c <=> g1p_c + udpgal_c h2o_c + 2.0 h_c + urdglyc_c --> co2_c + glx_c + 2.0 nh4_c alaala_c + atp_c + ugmd_c --> adp_c + h_c + pi_c + ugmda_c h2o_c + u3aga_c --> ac_c + u3hga_c 10fthf_c + udpLa4n_c --> h_c + thf_c + udpLa4fn_c uLa4n_c --> uLa4n_p LalaDgluMdap_c + atp_c + uamr_c --> adp_c + h_c + pi_c + ugmd_c h2o_c + um4p_c --> ala__D_c + ugmd_c LalaDgluMdapDala_c + atp_c + uamr_c --> adp_c + h_c + pi_c + um4p_c atp_c + ump_c <=> adp_c + udp_c ump_e <=> ump_p h2o_c + uLa4fn_c --> for_c + uLa4n_c udcpp_c + udpLa4fn_c --> uLa4fn_c + udp_c 2.0 amet_c + uppg3_c --> 2.0 ahcys_c + dscl_c + h_c hmbil_c --> h2o_c + uppg3_c 4.0 h_c + uppg3_c --> 4.0 co2_c + cpppg3_c prpp_c + ura_c --> ppi_c + ump_c h2o_c + uracp_c --> cbm_c + h_c + poaac_c h_p + ura_p --> h_c + ura_c h_p + ura_p <=> h_c + ura_c ura_e <=> ura_p nad_c + urdglyc_c --> h_c + nadh_c + oxur_c urea_e <=> urea_p urea_p <=> urea_c 2.0 h2o_c + o2_c + urate_c --> alltn_c + co2_c + h2o2_c h2o_c + uri_c --> rib__D_c + ura_c gtp_c + uri_c --> gdp_c + h_c + ump_c h_p + uri_p --> h_c + uri_c h_p + uri_p <=> h_c + uri_c uri_e <=> uri_p h2o_c + u23ga_c --> 2.0 h_c + lipidX_c + ump_c akg_c + val__L_c <=> 3mob_c + glu__L_c atp_c + trnaval_c + val__L_c --> amp_c + ppi_c + valtrna_c atp_c + h2o_c + val__L_p --> adp_c + h_c + pi_c + val__L_c h_p + val__L_p <=> h_c + val__L_c val__L_e <=> val__L_p 3mob_c + ala__L_c <=> pyr_c + val__L_c 2.0 h_c + mptamp_c + tungs_c --> amp_c + cu2_c + h2o_c + wco_c xu5p__L_c --> ru5p__L_c h2o_c + nad_c + xan_c --> h_c + nadh_c + urate_c h_p + xan_p --> h_c + xan_c xan_e <=> xan_p xan_p <=> xan_c xmp_e <=> xmp_p prpp_c + xan_c --> ppi_c + xmp_c h2o_c + xtsn_c --> rib__D_c + xan_c h_p + xtsn_p <=> h_c + xtsn_c xtsn_e <=> xtsn_p xyl__D_c <=> xylu__D_c glc__D_c <=> fru_c atp_c + xylu__D_c --> adp_c + h_c + xu5p__D_c atp_c + xylu__L_c --> adp_c + h_c + xu5p__L_c h_p + xylu__L_p --> h_c + xylu__L_c xylu__L_e <=> xylu__L_p atp_c + h2o_c + xyl__D_p --> adp_c + h_c + pi_c + xyl__D_c h_p + xyl__D_p --> h_c + xyl__D_c xyl__D_e <=> xyl__D_p atp_c + h2o_c + zn2_c --> adp_c + h_c + pi_c + zn2_p h_p + zn2_c --> h_c + zn2_p zn2_p --> zn2_c atp_c + h2o_c + zn2_p --> adp_c + h_c + pi_c + zn2_c zn2_e <=> zn2_p |
The model can be simulated by executing ~cameo.core.solver_based_model.SolverBasedModel.solve
.
solution = model.solve()
A quick overview of the solution can be obtained in form of a pandas DataFrame (all solution objects in cameo provide access to data frames through a data_frame
attribute).
solution
fluxes | reduced_costs | |
---|---|---|
DM_4crsol_c | 0.000219 | 0.000000 |
DM_5drib_c | 0.000221 | 0.000000 |
DM_aacald_c | -0.000000 | 0.000000 |
DM_amob_c | 0.000002 | 0.000000 |
... | ... | ... |
ZN2t3pp | 0.000000 | -0.002074 |
ZN2tpp | 0.000335 | 0.000000 |
ZNabcpp | 0.000000 | -0.008295 |
Zn2tex | 0.000335 | -0.000000 |
2583 rows × 2 columns
The data frame is accessible through solution.data_frame
.
solution.data_frame
fluxes | reduced_costs | |
---|---|---|
DM_4crsol_c | 0.000219 | 0.000000 |
DM_5drib_c | 0.000221 | 0.000000 |
DM_aacald_c | -0.000000 | 0.000000 |
DM_amob_c | 0.000002 | 0.000000 |
... | ... | ... |
ZN2t3pp | 0.000000 | -0.002074 |
ZN2tpp | 0.000335 | 0.000000 |
ZNabcpp | 0.000000 | -0.008295 |
Zn2tex | 0.000335 | -0.000000 |
2583 rows × 2 columns
Data frames make it very easy to process results. For example, let's take a look at reactions with flux != 0
solution.data_frame.query('fluxes != 0')
fluxes | reduced_costs | |
---|---|---|
DM_4crsol_c | 0.000219 | 0.0 |
DM_5drib_c | 0.000221 | 0.0 |
DM_amob_c | 0.000002 | 0.0 |
DM_mththf_c | 0.000440 | 0.0 |
... | ... | ... |
USHD | 0.019113 | 0.0 |
VALTA | -0.415702 | 0.0 |
ZN2tpp | 0.000335 | 0.0 |
Zn2tex | 0.000335 | -0.0 |
438 rows × 2 columns
Objects—models, reactions, metabolites, genes—can easily be explored in the Jupyter notebook, taking advantage of tab completion. For example, place your cursor after the period in model.reactions.
and press the TAB key. A dialog will appear that allows you to navigate the list of reactions encoded in the model.
model.reactions.PGK # delete PGK, place your cursor after the period and press the TAB key.
Id | PGK |
Name | Phosphoglycerate kinase |
Stoichiometry | 3pg_c + atp_c <=> 13dpg_c + adp_c |
GPR | b2926 |
Lower bound | -1000.000000 |
Upper bound | 1000.000000 |
For example, you can access the E4PD (Erythrose 4-phosphate dehydrogenase) reaction in the model.
model.reactions.E4PD
Id | E4PD |
Name | Erythrose 4-phosphate dehydrogenase |
Stoichiometry | e4p_c + h2o_c + nad_c <=> 4per_c + 2.0 h_c + nadh_c |
GPR | b2927 or b1779 |
Lower bound | -1000.000000 |
Upper bound | 1000.000000 |
Be aware though that due variable naming restrictions in Python dot notation access to reactions (and other objects) might not work in some cases.
# model.reactions.12DGR120tipp # uncommenting and running this cell will produce a syntax error
In these cases you need to use the model.reactions.get_by_id
.
model.reactions.get_by_id('12DGR120tipp')
Id | 12DGR120tipp |
Name | 1,2 diacylglycerol transport via flipping (periplasm to cytoplasm, n-C12:0) |
Stoichiometry | 12dgr120_p --> 12dgr120_c |
GPR | |
Lower bound | 0.000000 |
Upper bound | 1000.000000 |
Metabolites are accessible through model.metabolites
. For example, D-glucose in the cytosolic compartment.
model.metabolites.glc__D_c
Id | glc__D_c |
Name | D-Glucose |
Formula | C6H12O6 |
And it is easy to find the associated reactions
model.metabolites.glc__D_c.reactions
frozenset({<Reaction TRE6PH at 0x11543ec50>, <Reaction AMALT2 at 0x115069860>, <Reaction HEX1 at 0x1152d6860>, <Reaction GLCATr at 0x1152c44a8>, <Reaction TREH at 0x11543f0b8>, <Reaction XYLI2 at 0x115449908>, <Reaction MLTG4 at 0x1152f6d30>, <Reaction MLTG1 at 0x1152f6940>, <Reaction AMALT3 at 0x115069978>, <Reaction AMALT1 at 0x115071198>, <Reaction GALS3 at 0x1152c0da0>, <Reaction G6PP at 0x1152bf5c0>, <Reaction AMALT4 at 0x115069dd8>, <Reaction GLCabcpp at 0x1152c6e48>, <Reaction MLTG5 at 0x1152f6e80>, <Reaction MLTG2 at 0x1152f6a90>, <Reaction LACZ at 0x1152e2710>, <Reaction GLCt2pp at 0x1152c73c8>, <Reaction MLTG3 at 0x1152f6be0>})
A list of the genes encoded in the model can be accessed via model.genes
.
model.genes[0:10]
[<Gene b2215 at 0x11544ad30>, <Gene b1377 at 0x11544ad68>, <Gene b0241 at 0x11544ada0>, <Gene b0929 at 0x11544add8>, <Gene b4035 at 0x1152ef080>, <Gene b4033 at 0x1152ef0b8>, <Gene b4034 at 0x1152ef0f0>, <Gene b4032 at 0x1152ef128>, <Gene b4036 at 0x1152ef518>, <Gene b4213 at 0x1152507f0>]
A few additional attributes have been added that are not available in a cobrapy model. For example, exchange reactions that allow certain metabolites to enter or leave the model can be accessed through model.exchanges
.
model.exchanges[0:10]
[<Reaction DM_4crsol_c at 0x10cc53828>, <Reaction DM_5drib_c at 0x1118211d0>, <Reaction DM_aacald_c at 0x111821b00>, <Reaction DM_amob_c at 0x111821128>, <Reaction DM_mththf_c at 0x111821ac8>, <Reaction DM_oxam_c at 0x111821f28>, <Reaction EX_12ppd__R_e at 0x11413d6d8>, <Reaction EX_12ppd__S_e at 0x11413d8d0>, <Reaction EX_14glucan_e at 0x11413da20>, <Reaction EX_15dap_e at 0x11413dda0>]
Or, the current medium can be accessed through model.medium
.
model.medium
reaction_id | reaction_name | lower_bound | upper_bound | |
---|---|---|---|---|
0 | EX_ca2_e | Calcium exchange | -1000.00 | 1000.0 |
1 | EX_cbl1_e | Cob(I)alamin exchange | -0.01 | 1000.0 |
2 | EX_cl_e | Chloride exchange | -1000.00 | 1000.0 |
3 | EX_co2_e | CO2 exchange | -1000.00 | 1000.0 |
... | ... | ... | ... | ... |
21 | EX_slnt_e | Selenite exchange | -1000.00 | 1000.0 |
22 | EX_so4_e | Sulfate exchange | -1000.00 | 1000.0 |
23 | EX_tungs_e | Tungstate exchange | -1000.00 | 1000.0 |
24 | EX_zn2_e | Zinc exchange | -1000.00 | 1000.0 |
25 rows × 4 columns
It is also possible to get a list of essential reactions ...
model.essential_reactions()[0:10]
[<Reaction DM_4crsol_c at 0x10cc53828>, <Reaction DM_5drib_c at 0x1118211d0>, <Reaction DM_amob_c at 0x111821128>, <Reaction DM_mththf_c at 0x111821ac8>, <Reaction BIOMASS_Ec_iJO1366_core_53p95M at 0x11185f160>, <Reaction EX_ca2_e at 0x11417a1d0>, <Reaction EX_cl_e at 0x11417f550>, <Reaction EX_cobalt2_e at 0x11417fc88>, <Reaction EX_cu2_e at 0x1141877f0>, <Reaction EX_glc__D_e at 0x1141cc048>]
... and essential genes.
model.essential_genes()[0:10]
[<Gene b3730 at 0x115444080>, <Gene b3805 at 0x1152d80f0>, <Gene b0090 at 0x115444208>, <Gene b3939 at 0x115434240>, <Gene b3648 at 0x1152c42b0>, <Gene b3058 at 0x114c14320>, <Gene b0088 at 0x115444320>, <Gene b1281 at 0x11540c358>, <Gene b0131 at 0x1150203c8>, <Gene b0154 at 0x1152bc400>]