This notebook contains material from PyRosetta; content is available on Github.

Working With Antibodies

Keywords: Antibody, RosettaAntibody, RosettaAntibodyDesign, RAbD, CDR

Overview

If you are here, you probably understand a thing or two about antibodies. Lets do a quick review anyway.

In [1]:
from IPython.display import Image
Image('./Media/antibody/antibody_structure_overview.png',width='1000')
Out[1]:

IgG

Here is the full IgG that has two Fabs or antibody fragments. Each Fab has a variable (Fv) and constant (Fc) region. In Rosetta, we are mostly concerned with Fv - where the binding region actually resides. The molecule that an antibody binds to is called an antigen.

In [2]:
Image('./Media/antibody/antibody_structure_IgG.png',width='1000')
Out[2]: