Mickey Atwal, CSHL

- (a) What is the probability of observing at least one active compound out of two assays?

- (b) What is the probability of observing at least one active compound out of N assays?

- (c) How large a library do we need to be 99% sure that we will find at least one active molecule?

- (a) What is the average time between spikes?

- (b) What is the probability distribution for the time, $T$ , between spikes?

- (d) How do you reconcile the results of (a) and (c) ?

$\mathbf{4}$ . Let’s simulate a Poisson process with a constant rate $m$ in Python.

- (a) What is the probability that this woman is a carrier?

- (f) Plot a histogram of all the p-values.

- (g) Estimate approximately how many genes are differentially expressed.